fibrin and Toxemia

fibrin has been researched along with Toxemia* in 5 studies

Other Studies

5 other study(ies) available for fibrin and Toxemia

ArticleYear
Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees.
    The Journal of experimental medicine, 1994, Apr-01, Volume: 179, Issue:4

    The role of interleukin 6 (IL-6) in the toxic sequelae of sepsis is controversial. To assess the part of IL-6 in inflammatory responses to endotoxin, we investigated eight chimpanzees after either a bolus intravenous injection of Escherichia coli endotoxin (n = 4; 4 ng/kg) or after the same dose of endotoxin with a simultaneous bolus intravenous injection of an anti-IL-6 mAb (30 mg; n = 4). Anti-IL-6 did not affect the induction of the cytokine network (tumor necrosis factor [TNF], soluble TNF receptors types I and II, and IL-8) by endotoxin, nor did it influence the occurrence of a neutrophilic leukocytosis and neutrophil degranulation, as monitored by the measurement of elastase-alpha 1-antitrypsin complexes. In contrast, anti-IL-6 markedly attenuated endotoxin-induced activation of coagulation, monitored with the plasma levels of the prothrombin fragment F1+2 and thrombin-antithrombin III complexes, whereas activation of fibrinolysis, determined with the plasma concentrations of plasmin-alpha 2-antiplasmin complexes, remained unaltered. We conclude that IL-6 does not have a feedback effect on the release of other cytokines after injection of endotoxin, and that it is not involved in endotoxin-induced neutrophilia or neutrophil degranulation. IL-6 is, however, an important intermediate factor in activation of coagulation in low grade endotoxemia in chimpanzees.

    Topics: Animals; Antibodies, Monoclonal; Blood Coagulation; Cell Count; Endotoxins; Fibrin; Humans; Injections, Intravenous; Interleukin-6; Interleukin-8; Monocytes; Neutrophils; Pan troglodytes; Receptors, Tumor Necrosis Factor; Toxemia; Tumor Necrosis Factor-alpha

1994
An investigation into the mechanism of placental damage in rats inoculated with Salmonella dublin.
    The American journal of pathology, 1974, Volume: 77, Issue:2

    Rats were inoculated with viable Salmonella dublin organisms, or a crude S dublin endotoxin, at the fourteenth and nineteenth days of pregnancy. They were killed at intervals up to 96 hours after inoculation, and the pathogenesis of the lesions was compared. At each stage of pregnancy the initial lesions produced by live bacteria and crude endotoxin showed important similarities, confirming the significance of endotoxin in the pathogenesis of placental damage. There were differences in the later stages of the pathogenic process. Comparisons of the process of placental damage at the two stages of pregnancy have suggested that the same mechanism acts throughout the last third of pregnancy and that thrombosis and disseminated intravascular coagulation are not an important part of the mechanism of placental damage.

    Topics: Animals; Disseminated Intravascular Coagulation; Endotoxins; Female; Fetal Death; Fibrin; Granulation Tissue; Hemorrhage; Necrosis; Neutrophils; Placenta; Placenta Diseases; Pregnancy; Pregnancy Complications, Infectious; Rats; Salmonella Infections, Animal; Sodium Chloride; Thrombosis; Time Factors; Toxemia; Uterus

1974
Intravascular fat in the renal cortex.
    Annals of surgery, 1971, Volume: 174, Issue:1

    Topics: Angiography; Animals; Blood Coagulation Disorders; Disseminated Intravascular Coagulation; Embolism, Fat; Escherichia coli Infections; Female; Fibrin; Infarction; Kidney; Kidney Cortex Necrosis; Kidney Diseases; Kidney Glomerulus; Lipids; Rabbits; Shwartzman Phenomenon; Toxemia; Triglycerides

1971
Shwartzman reaction after human renal homotransplantation.
    The New England journal of medicine, 1968, Mar-21, Volume: 278, Issue:12

    Topics: Adolescent; Adult; Cadaver; Female; Fibrin; Humans; Immunosuppressive Agents; Kidney; Kidney Glomerulus; Kidney Transplantation; Male; Renal Dialysis; Sepsis; Shwartzman Phenomenon; Toxemia; Transplantation Immunology; Transplantation, Homologous

1968
Fibrinolytic activity in blood serum during pregnancy complicated by hypertensive toxemias.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1946, Volume: 62, Issue:2

    Topics: Blood; Blood Pressure; Female; Fibrin; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Serum; Thrombolytic Therapy; Toxemia

1946