fibrin and Tooth-Fractures

The aim of this report is to describe a novel method of revascularization therapy done in a non-vital, immature permanent tooth using Platelet-rich fibrin (PRF),in a recently developed scaffold material to overcome limitations associated with the traditional method of revascularization using natural blood clot. PRF prepared from autologous blood was placed in the root canal and patient was followed up regularly at one, three, six, nine and 12 months for detailed clinical and radiographic evaluation. At 12 months, radiographic examination revealed root elongation, root end closure, continued thickening of the root dentinal walls, obliteration of root canal space, and normal periradicular anatomy. However, more long term prospective trials and histological studies are highly needed before to testify PRF a panacea for the regenerative endodontic therapy in children.

Topics: Anti-Bacterial Agents; Apexification; Blood Platelets; Child; Ciprofloxacin; Dental Pulp Cavity; Dental Pulp Necrosis; Dentin; Drug Combinations; Fibrin; Follow-Up Studies; Humans; Incisor; Male; Metronidazole; Minocycline; Root Canal Preparation; Tissue Scaffolds; Tooth Apex; Tooth Fractures; Tooth, Nonvital

Topics: Blood Platelets; Bone Substitutes; Dental Implant-Abutment Design; Dental Materials; Esthetics, Dental; Female; Fibrin; Follow-Up Studies; Gingiva; Humans; Immediate Dental Implant Loading; Incisor; Leukocytes; Maxilla; Middle Aged; Osseointegration; Titanium; Tooth Crown; Tooth Extraction; Tooth Fractures