fibrin and Temporomandibular-Joint-Disorders

As social and health needs are changing, new challenges to develop innovative alternatives arise to address unmet medical needs. Personalized medicine is emerging as a promising and appealing therapeutic option. The use of patient's own plasma and platelets as therapeutics is providing new avenues in the treatment of acute and chronic tissue injuries by promoting tissue repair and regeneration. Plasma and platelet-based therapies mimic the physiological repair process by releasing autologous growth factors and creating a natural, biodegradable and transient scaffold that acts as transient matrix. This review summarizes the recent advances and challenges in the field of personalized plasma-based medicine and its potential to treat age-related diseases.

Topics: Dry Eye Syndromes; Fibrin; Humans; Intercellular Signaling Peptides and Proteins; Platelet-Rich Plasma; Precision Medicine; Regeneration; Temporomandibular Joint Disorders; Tendinopathy; Transplantation, Autologous

To evaluate the influence of impaired masseter function during growth on the development of temporomandibular synovitis.. Sixteen 3-week-old male Wistar rats were classified into four groups. The first group served as control; and in the second group, jaw opening was forced for 3 hours when the rats were 9 weeks old. In the third and fourth groups, the masseter muscles were bilaterally resected at 3 weeks of age, and the rats in the fourth group were additionally forced to open their jaw at 9 weeks of age. All rats were sacrificed at 9 weeks. Temporomandibular joint (TMJ) tissue samples were processed for histology, and evaluated for cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expressions by immunohistochemistry to examine the inflammatory changes in the synovial membrane.. The control group showed noninflammatory changes. In the jaw-opening group, vascular dilation and weak COX-2 immunoreactivity were induced by jaw opening in the synovium. In the masseter-resection group, the masseter-resected rats exhibited moderate synovial changes while in the resection with opening group, the masseter-resected rats revealed more significant inflammatory changes including synovial hyperplasia, dilated vasculature, fibrin deposits, and intense immunoreactivity for COX-2 and iNOS, all caused by jaw opening.. These results suggest that masseter activity in the growth period is an important factor in the induction of temporomandibular synovitis.

Topics: Animals; Cyclooxygenase 2; Dilatation, Pathologic; Fibrin; Hyperplasia; Immunohistochemistry; Male; Masseter Muscle; Muscle Weakness; Nitric Oxide Synthase Type II; Range of Motion, Articular; Rats; Rats, Wistar; Stress, Mechanical; Synovial Membrane; Synovitis; Temporomandibular Joint; Temporomandibular Joint Disorders; Vascular Diseases