fibrin and Paraneoplastic-Syndromes

fibrin has been researched along with Paraneoplastic-Syndromes* in 2 studies

Other Studies

2 other study(ies) available for fibrin and Paraneoplastic-Syndromes

Article	Year
Circulating microparticles bearing Fibrin associated with whole-body 18FDG-PET: diagnostic tools to detect paraneoplastic polymyalgia rheumatica. Rheumatology international, 2016, Volume: 36, Issue:8 Polymyalgia rheumatica (PMR), a chronic inflammatory rheumatism, can be the expression of a paraneoplastic syndrome. The same clinical symptoms are frequently observed at the early stage of the benign and malignant forms. Here, our aim was to develop diagnostic tools to differentiate paraneoplastic PMR from essential PMR. We combined an 18FDG-PET and detection of circulating procoagulant microparticles (MPs), such as fibrin positive (FibMPs), by flow cytometry. Two patients with PMR and a similar profile were selected. In the two patients, the 18FDG-PET revealed a hypermetabolic focus. However, the concentrations of fibrin+/annexin+ microparticles detected were (10 times higher in one of the two patients, who was later found to have breast cancer. The association of 18FDG-PET and the detection of microparticle fibrin positives by flow cytometry allows separating essential PMR (hypermetabolism by 18FDG-PET, low FibMPs) from paraneoplastic PMR. Topics: Aged; Breast Neoplasms; Cell-Derived Microparticles; Colonic Neoplasms; Female; Fibrin; Fluorodeoxyglucose F18; Humans; Middle Aged; Paraneoplastic Syndromes; Polymyalgia Rheumatica; Positron Emission Tomography Computed Tomography; Whole Body Imaging	2016
Acquired dysfibrinogenemia. Paraneoplastic syndrome in renal cell carcinoma. The American journal of medicine, 1985, Volume: 78, Issue:4 Acquired dysfibrinogenemia has not been previously reported as a paraneoplastic marker for malignancy. This report describes the clinical course of a patient who at the time of diagnosis of nonmetastatic renal cell carcinoma had dysfibrinogenemia characterized by prolongation of the thrombin and Reptilase times and increased sialic acid content of the purified fibrinogen. The thrombin and Reptilase times returned toward normal values after nephrectomy but became abnormal with the development of nonhepatic metastases. It is concluded that acquired dysfibrinogenemia can be part of a paraneoplastic syndrome and is a sensitive plasma marker for tumor progression. Topics: Carcinoma, Renal Cell; Female; Fibrin; Fibrinogen; Follow-Up Studies; Humans; Kidney Neoplasms; Lung Neoplasms; Middle Aged; N-Acetylneuraminic Acid; Nephrectomy; Paraneoplastic Syndromes; Sialic Acids; Thrombin Time	1985

Article

Year

Circulating microparticles bearing Fibrin associated with whole-body 18FDG-PET: diagnostic tools to detect paraneoplastic polymyalgia rheumatica.

Rheumatology international, 2016, Volume: 36, Issue:8

Polymyalgia rheumatica (PMR), a chronic inflammatory rheumatism, can be the expression of a paraneoplastic syndrome. The same clinical symptoms are frequently observed at the early stage of the benign and malignant forms. Here, our aim was to develop diagnostic tools to differentiate paraneoplastic PMR from essential PMR. We combined an 18FDG-PET and detection of circulating procoagulant microparticles (MPs), such as fibrin positive (FibMPs), by flow cytometry. Two patients with PMR and a similar profile were selected. In the two patients, the 18FDG-PET revealed a hypermetabolic focus. However, the concentrations of fibrin+/annexin+ microparticles detected were (10 times higher in one of the two patients, who was later found to have breast cancer. The association of 18FDG-PET and the detection of microparticle fibrin positives by flow cytometry allows separating essential PMR (hypermetabolism by 18FDG-PET, low FibMPs) from paraneoplastic PMR.

Topics: Aged; Breast Neoplasms; Cell-Derived Microparticles; Colonic Neoplasms; Female; Fibrin; Fluorodeoxyglucose F18; Humans; Middle Aged; Paraneoplastic Syndromes; Polymyalgia Rheumatica; Positron Emission Tomography Computed Tomography; Whole Body Imaging

2016

Acquired dysfibrinogenemia. Paraneoplastic syndrome in renal cell carcinoma.

The American journal of medicine, 1985, Volume: 78, Issue:4

Acquired dysfibrinogenemia has not been previously reported as a paraneoplastic marker for malignancy. This report describes the clinical course of a patient who at the time of diagnosis of nonmetastatic renal cell carcinoma had dysfibrinogenemia characterized by prolongation of the thrombin and Reptilase times and increased sialic acid content of the purified fibrinogen. The thrombin and Reptilase times returned toward normal values after nephrectomy but became abnormal with the development of nonhepatic metastases. It is concluded that acquired dysfibrinogenemia can be part of a paraneoplastic syndrome and is a sensitive plasma marker for tumor progression.

Topics: Carcinoma, Renal Cell; Female; Fibrin; Fibrinogen; Follow-Up Studies; Humans; Kidney Neoplasms; Lung Neoplasms; Middle Aged; N-Acetylneuraminic Acid; Nephrectomy; Paraneoplastic Syndromes; Sialic Acids; Thrombin Time

1985