fibrin and Osteoporosis--Postmenopausal

The aim of this study was to report a case of severe bilateral fibrinous anterior uveitis following pamidronate therapy in a patient on latanoprost.. This study is presented as an interventional case report.. Clinical examination showed bilateral severe fibrinous uveitis following an intravenous infusion of disodium pamidronate. Ocular signs and symptoms responded to stopping latanoprost and treatment with oral prednisolone (60 mg) and hourly topical prednisolone acetate 1%. The reintroduction of latanoprost resulted in a recurrence, which was stopped with subsequent improvement.. Mild anterior uveitis is an unfamiliar adverse effect of pamidronate therapy. However, severe fibrinous uveitis has not been previously described. This may be due to the compounding effect of latanoprost. This case highlights the importance of history taking and awareness of the otherwise uncommon side effect of this commonly prescribed medication.

Topics: Acute Disease; Administration, Topical; Aged, 80 and over; Anti-Inflammatory Agents; Bone Density Conservation Agents; Diphosphonates; Drug Interactions; Female; Fibrin; Glaucoma, Open-Angle; Humans; Infusions, Intravenous; Latanoprost; Osteoporosis, Postmenopausal; Pamidronate; Prednisolone; Prostaglandins F, Synthetic; Recurrence; Uveitis, Anterior