fibrin and Neuroendocrine-Tumors

Cell migration, known as an orchestrated movement of cells, is crucially important for wound healing, tumor growth, immune response as well as other biomedical processes. This paper presents a cell-based model to describe cell migration in non-isotropic fibrin networks around pancreatic tumor islets. This migration is determined by the mechanical strain energy density as well as cytokines-driven chemotaxis. Cell displacement is modeled by solving a large system of ordinary stochastic differential equations where the stochastic parts result from random walk. The stochastic differential equations are solved by the use of the classical Euler-Maruyama method. In this paper, the influence of anisotropic stromal extracellular matrix in pancreatic tumor islets on T-lymphocytes migration in different immune systems is investigated. As a result, tumor peripheral stromal extracellular matrix impedes the immune response of T-lymphocytes through changing direction of their migration.

Topics: Adenoma, Islet Cell; Anisotropy; Biomechanical Phenomena; Cell Count; Cell Movement; Collagen; Computer Simulation; Epithelial Cells; Fibrin; Humans; Models, Biological; Neuroendocrine Tumors; Numerical Analysis, Computer-Assisted; T-Lymphocytes