fibrin and Meningioma

fibrin has been researched along with Meningioma* in 6 studies

Other Studies

6 other study(ies) available for fibrin and Meningioma

ArticleYear
Olfactory preservation during anterior interhemispheric approach for anterior skull base lesions: technical note.
    Neurosurgical review, 2016, Volume: 39, Issue:1

    Anosmia is not a rare complication of surgeries that employ the anterior interhemispheric approach. Here, we present a fibrin-gelatin fixation method that provides reinforcement and moisture to help preserve the olfactory nerve when using the anterior interhemispheric approach and describe the results and outcomes of this technique. We analyze the outcomes with this technique in 45 patients who undergo surgery for aneurysms, brain tumors, or other pathologies via the anterior interhemispheric approach. Anosmia occurred in 4 patients (8.8%); it was transient in 2 (4.4%) and permanent in the remaining 2 (4.4%). Brain tumors clearly attached to the olfactory nerve were resected in the patients with permanent anosmia. We found a significant difference in the presence of anosmia between patients with or without lesions that were attaching the olfactory nerve (pā€‰=ā€‰0.011). Our results suggested that fibrin-gelatin fixation method can reduce the reported risk of anosmia. However, the possibility of olfactory nerve damage is relatively high when operating on brain tumors attaching olfactory nerve.

    Topics: Adult; Aged; Craniopharyngioma; Craniotomy; Female; Fibrin; Gelatin; Humans; Intracranial Aneurysm; Male; Meningioma; Middle Aged; Neurosurgical Procedures; Olfaction Disorders; Olfactory Nerve Injuries; Postoperative Complications; Skull Base; Skull Base Neoplasms; Smell; Young Adult

2016
Canine intracranial meningiomas: Immunohistochemical evaluation of tissue factor, fibrin/fibrinogen and D-dimers.
    Veterinary journal (London, England : 1997), 2015, Volume: 206, Issue:3

    The haemostatic system influences angiogenesis, cell growth and metastasis in solid tumours. The aim of this study was to investigate tissue factor (TF) expression, fibrin/fibrinogen and D-dimer deposition, as well as the occurrence of intravascular thrombosis (IVT) in canine intracranial meningiomas using immunohistochemistry. All but three (26/29) meningiomas expressed TF. TF immunolabelling was significantly higher in high-grade (grades II and III) than in low-grade (grade I) meningiomas. Fibrin/fibrinogen and D-dimer deposits were detected in all meningiomas and staining scores were statistically different between different meningioma grades. IVT was detected in 19/29 specimens, but no statistical differences were observed between different malignancy grades. In conclusion, the haemostatic system may be involved in meningioma pathobiology and may be a potential therapeutic target for canine meningiomas, as also suggested for human meningiomas.

    Topics: Animals; Dog Diseases; Dogs; Fibrin; Fibrin Fibrinogen Degradation Products; Immunohistochemistry; Meningeal Neoplasms; Meningioma; Thromboplastin

2015
Immunohistochemical detection of vascular growth factors in angiomatous and atypical meningiomas, as well as hemangiopericytomas.
    Pathology, research and practice, 1997, Volume: 193, Issue:7

    The arachnoideal compartment provides the vascular sources for three different tumor types rich in vessels: angiomatous meningioma, some atypical meningioma with high vascularity and meningeal hemangiopericytoma. We investigated immunohistochemically the expression and distribution of vascular mitogenes in 7 angiomatous meningiomas, 8 atypical meningiomas with high vasculature and 4 hemangiopericytomas. On the one hand it should be studied which vascular growth factors such as VPF/VEGF-1, VPF/VEGF-2, bFGF, PDGF and TGF-alpha could be responsible for the close meshwork of vessels within the tumors. On the other hand we were interested in whether or not there are differences in vascular mitogens between slowly growing angiomatous meningiomas and both other types with their increased tendency to recur. PDGF and TGF-alpha were extensively expressed in the endothelium and smooth muscle cells of the vessels, as well as tumor cells. VEGF-2 could only be found in endothelial cells of all three tumor entities. bFGF was localized in some vessels of angiomatous meningiomas and VEGF-1 revealed a very low expression with a localization comparable with VEGF-2. Moreover, uPAR was diffusely expressed in nearly all tumor cells and endothelial cells. The fact that tumor cells of hemangiopericytomas and meningiomas did not show any immunohistochemical reaction with VEGF's could indicate a lower priority of these growth factors for neovascularization in this type of neoplasm. A different expression of vascular mitogens between benign angiomatous meningiomas and atypical meningiomas as well as hemangiopericytomas with their tendency for recurrence could not be observed. The morphological evidence for extravasates of IgG-proteins, Fibrin and Fibronectin due to VPF-effects seems not to be a renouncable condition for neoangiogenesis in the tumors investigated.

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Endothelial Growth Factors; Endothelium, Vascular; Female; Fibrin; Fibroblast Growth Factor 2; Growth Substances; Hemangioma; Hemangiopericytoma; Humans; Immunohistochemistry; Lymphokines; Male; Meningioma; Middle Aged; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Transforming Growth Factor alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

1997
[Cerebral angioblastoma in advanced age with severe regressive lesions. A histological examination concerning the pathogenesis of the tumour and its regressions].
    Acta neuropathologica, 1970, Volume: 15, Issue:1

    Topics: Adenocarcinoma; Aged; Brain Neoplasms; Cell Transformation, Neoplastic; Diagnosis, Differential; Fibrin; Hemangiopericytoma; Hemangiosarcoma; Hemosiderin; Humans; Male; Meningioma; Neoplasm Metastasis; Neoplasm Regression, Spontaneous

1970
The fibrinogen-fibrin system in human intracranial tumor tissues: an immunohistological study.
    Nihon geka hokan. Archiv fur japanische Chirurgie, 1969, Jul-01, Volume: 38, Issue:4

    Topics: Animals; Antigens; Brain Neoplasms; Carcinoma, Ehrlich Tumor; Fibrin; Fibrinogen; Fluorescent Antibody Technique; Glioblastoma; Glioma; Humans; Immunodiffusion; Immunoelectrophoresis; Iodine Isotopes; Meningioma; Mice; Neoplasms, Experimental; Plasminogen; Rabbits; Radiometry; Radionuclide Imaging; Rats; Sarcoma, Yoshida

1969
THE CELL-CATCH PROCEDURE. A NEW METHOD WHICH PRESERVES ALL CELLULAR ELEMENTS OF SPINAL-FLUID SAMPLES.
    Journal of neurosurgery, 1963, Volume: 20

    Topics: Brain Neoplasms; Cerebellar Neoplasms; Cerebrospinal Fluid; Cytodiagnosis; Equipment and Supplies; Fibrin; Medulloblastoma; Meningeal Neoplasms; Meningioma; Meningitis; Research; Specimen Handling

1963