fibrin and Meningeal-Neoplasms

The haemostatic system influences angiogenesis, cell growth and metastasis in solid tumours. The aim of this study was to investigate tissue factor (TF) expression, fibrin/fibrinogen and D-dimer deposition, as well as the occurrence of intravascular thrombosis (IVT) in canine intracranial meningiomas using immunohistochemistry. All but three (26/29) meningiomas expressed TF. TF immunolabelling was significantly higher in high-grade (grades II and III) than in low-grade (grade I) meningiomas. Fibrin/fibrinogen and D-dimer deposits were detected in all meningiomas and staining scores were statistically different between different meningioma grades. IVT was detected in 19/29 specimens, but no statistical differences were observed between different malignancy grades. In conclusion, the haemostatic system may be involved in meningioma pathobiology and may be a potential therapeutic target for canine meningiomas, as also suggested for human meningiomas.

Topics: Animals; Dog Diseases; Dogs; Fibrin; Fibrin Fibrinogen Degradation Products; Immunohistochemistry; Meningeal Neoplasms; Meningioma; Thromboplastin

Topics: Brain Neoplasms; Cerebellar Neoplasms; Cerebrospinal Fluid; Cytodiagnosis; Equipment and Supplies; Fibrin; Medulloblastoma; Meningeal Neoplasms; Meningioma; Meningitis; Research; Specimen Handling