fibrin and Maxillary-Diseases

Platelet-rich fibrin (PRF) has been recently used as the sole grafting material in sinus floor elevation procedures. The aim of this prospective study was to measure the bone gain around the dental implant after using the crestal approach to sinus floor elevation using platelet-rich fibrin as the only grafting material in atrophic posterior maxillae with residual bone height <5 mm.. Two different types of implants were used: hydroxyapatite (HA) and sandblasted acid-etched (SA) implants. Panoramic radiography and computed tomography were used to measure the endosinus bone gain.. Twenty-seven patients with 39 implants (19 HA and 20 SA) were included in this study. The mean residual bone measurements before surgery in the SA and HA groups were 2.85 and 2.68 mm, respectively. The mean average bone gains for 1 year in the SA and HA groups were 4.38 and 4.00 mm, respectively.. This prospective study showed that platelet-rich fibrin promoted endosinus bone gain when used as the grafting material in the crestal approach to sinus floor elevation.

Topics: Adult; Aged; Alveolar Bone Loss; Blood Platelets; Bone Regeneration; Female; Fibrin; Humans; Male; Maxillary Diseases; Middle Aged; Prospective Studies; Radiography, Panoramic; Sinus Floor Augmentation; Tomography, X-Ray Computed

The aim of the present study is to assess the implant osteointegration, as well as the course of bone regeneration and healing processes, thanks to the sinus lift procedure and by using PRF as a filling material, in association with the Bio-Oss.. 23 patients, requiring maxillary sinus lift in order to place implants into posterior maxillary region, were involved in this study. Selected cases, in which the height of the residual bone was superior to 5 mm, were adopted for surgical procedure of "one-stage sinus lift" (implant insertion concurrently occured with sinus lift resulting 6-9 months the healing and integration time). Before inserting the implant, a small quantity of filling material was placed in the cavity. For this purpose the bone fragment, stored in saline solution, was employed mixed with Bio-Oss and PRF, after being ground.. All patients reported no pain to percussion, no sign of tissue suffering in the soft peri-implant tissues, the presence of an optimal primary stability of the inserted implants and a significant increase in the peri-implant bone density.. In all cases included in this protocol, the Authors observed a successful implant-prosthetic rehabilitation, according with Albrektsson criteria.

Topics: Alveolar Bone Loss; Blood Transfusion, Autologous; Bone Regeneration; Bone Substitutes; Bone Transplantation; Dental Implantation; Fibrin; Humans; Italy; Maxilla; Maxillary Diseases; Minerals; Osseointegration; Platelet Transfusion; Severity of Illness Index; Time Factors; Tomography, X-Ray Computed; Treatment Outcome

To report on the outcomes of a new surgical technique for the treatment of severe horizontal bone resorption that impedes the placement of dental implants.. Eleven patients in need of bone augmentation to reconstruct a narrow alveolar ridge were recruited for the present study. Surgical correction of the alveolar width was performed by harvesting an onlay bone graft from the lateral wall of the maxillary sinus and filling the intervening space with plasma rich in growth factors alone or mixed with autologous bone particles. A fibrin membrane was then placed to cover the surgical site before flap closure. Clinical examinations and cone-beam computed tomography were performed to analyze the safety and efficiency of an onlay bone graft from the maxilla in horizontal bone augmentation.. The present study is the first to describe the lateral wall of the maxillary sinus as a donor site for an onlay bone graft. The healing period was uneventful, with minimal surgical morbidity. No flap exposure occurred, and analysis of the cone-beam computed tomography scans before and after (about 5 months) bone augmentation revealed a total gain of 5.4 mm in alveolar width. This permitted the placement of dental implants to support an implant-borne prosthesis.. An onlay bone graft from the lateral wall of the maxillary sinus is a useful and safe tool for horizontal bone augmentation with minimal surgical morbidity.

Topics: Alveolar Bone Loss; Autografts; Bone Transplantation; Cone-Beam Computed Tomography; Dental Arch; Dental Implantation, Endosseous; Female; Fibrin; Follow-Up Studies; Humans; Intercellular Signaling Peptides and Proteins; Male; Maxillary Diseases; Maxillary Sinus; Middle Aged; Piezosurgery; Platelet-Rich Plasma; Retrospective Studies; Safety; Sinus Floor Augmentation; Transplant Donor Site; Treatment Outcome

Our aim was to assess the feasibility of using leucocyte-rich and platelet-rich fibrin (L-PRF) for the treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in a single group study. After treatment with L-PRF, the response of each patient was recorded 1 month and 4 months postoperatively. Further assessments were made of the site, stage, concentration of c-terminal crosslinked telopepide of type 1 collagen, and actinomycosis. Among the total of 34 patients, 26 (77%) showed complete resolution, 6 (18%) had delayed resolution, and 2 (6%) showed no resolution. There was a significant association between the response to treatment and the stage of BRONJ (p=0.002) but no other significant associations were detected. This study has shown that it is feasible to use L-PRF for the treatment of BRONJ, but the effectiveness cannot be judged with this study design. Randomised prospective trials are needed to confirm this.

Topics: Actinomycosis; Aged; Biopsy; Bisphosphonate-Associated Osteonecrosis of the Jaw; Blood Platelets; Collagen Type I; Debridement; Feasibility Studies; Female; Fibrin; Follow-Up Studies; Humans; Leukocytes; Mandibular Diseases; Maxillary Diseases; Middle Aged; Peptides; Pilot Projects; Prospective Studies; Therapeutic Irrigation; Treatment Outcome; Wound Healing