fibrin has been researched along with Mastocytosis* in 1 studies
1 review(s) available for fibrin and Mastocytosis
| Article | Year |
|---|---|
Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation.
Tetramer-forming tryptase (hTryptase-β) was recently discovered to have a prominent role in preventing the internal accumulation of life-threatening fibrin deposits and fibrin-platelet clots. The anticoagulant activity of hTryptase-β is an explanation for the presence of hemorrhagic disorders in some patients with anaphylaxis or mastocytosis. The fragments of hFibrinogen formed by the proteolysis of this prominent protein by hTryptase-β could be used as biomarkers in the blood and/or urine for the identification and monitoring of patients with mast cell-dependent disorders. Recombinant hTryptase-β has potential to be used in clinical settings where it is desirable to inhibit blood coagulation. Topics: Anaphylaxis; Blood Coagulation; Fibrin; Fibrinogen; Gene Expression Regulation, Neoplastic; Histamine; Humans; Isoenzymes; Mast Cells; Mastocytosis; Protein Multimerization; Signal Transduction; Skin; Thrombin; Tryptases | 2014 |