fibrin and Mandibular-Diseases

The treatment of molar furcation defects remains a considerable challenge in clinical practice. The identification of clinical measurements influential to treatment outcomes is critical to optimize the results of surgical periodontal therapy. The present study aimed to explore the clinical and radiographical effectiveness of autologous platelet-rich fibrin (PRF) and autologous platelet-rich plasma (PRP) in the treatment of mandibular degree II furcation defects in subjects with chronic periodontitis.. Seventy-two mandibular degree II furcation defects were treated with either autologous PRF with open flap debridement (OFD; 24 defects) or autologous PRP with OFD (25), or OFD alone (23). Clinical and radiological parameters such as probing depth, relative vertical clinical attachment level and horizontal clinical attachment level along with gingival marginal level were recorded at baseline and 9 mo postoperatively.. All clinical and radiographic parameters showed statistically significant improvement at both the test sites (PRF with OFD and PRP with OFD) compared to those with OFD alone. Relative vertical clinical attachment level gain was also greater in PRF (2.87 ± 0.85 mm) and PRP (2.71 ± 1.04 mm) sites as compared to control site (1.37 ± 0.58 mm), and relative horizontal clinical attachment level gain was statistically significantly greater in both PRF and PRP than in the control group.. The use of autologous PRF or PRP were both effective in the treatment of furcation defects with uneventful healing of sites.

Topics: Adult; Autografts; Blood Transfusion, Autologous; Bone Regeneration; Chronic Periodontitis; Debridement; Dental Plaque Index; Female; Fibrin; Follow-Up Studies; Furcation Defects; Gingival Recession; Humans; Male; Mandibular Diseases; Molar; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Platelet Transfusion; Platelet-Rich Plasma; Surgical Flaps; Treatment Outcome

BACKGROUND The restoration of damaged periodontium, especially one-wall intrabony defects, is a major challenge for clinicians. Concentrated growth factors (CGF) are a 100% autologous fibrin with multiple concentrated growth factors. The rigid fibrin structure of CGF makes it possible to preserve or reconstruct the initial bone volume. The aim of this study was to evaluate the clinical healing patterns after surgical application of CGF with and without a Bio-Oss graft in one-wall infrabony defects. MATERIAL AND METHODS We randomly divided 120 one-wall intrabony defects in 54 patients into 4 groups: flap surgery alone (Group 1), flap surgery with autologous CGF (Group 2), flap surgery with Bio-Oss (Group 3), and flap surgery with CGF+Bio-Oss (Group 4). Clinical parameters such as probing depth (PD) and clinical attachment level (CAL) change were recorded at baseline and at 6 and 12 months postoperatively. RESULTS At 12 months postoperatively, Group 2 showed significant improvement in clinical parameters over Group 1 (P<0.05) and the results were significantly greater in Groups 3 and 4 compared to the other groups (P<0.05). Although no significant difference was noted between Groups 3 and 4 in clinical parameters (P>0.05) compared to Group 3, the mean change of CAL at 6-12 months in Group 4 was not significant (P>0.05). CONCLUSIONS CGF reduced periodontal intrabony defects depth and, when mixed with Bio-Oss, CGF showed better results in the early period and the effect was more stable.

Topics: Adult; Alveolar Bone Loss; Bone Regeneration; Bone Substitutes; China; Chronic Periodontitis; Female; Fibrin; Follow-Up Studies; Humans; Intercellular Signaling Peptides and Proteins; Male; Mandibular Diseases; Middle Aged; Minerals; Periodontal Index; Periodontal Ligament; Wound Healing

Our aim was to assess the feasibility of using leucocyte-rich and platelet-rich fibrin (L-PRF) for the treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in a single group study. After treatment with L-PRF, the response of each patient was recorded 1 month and 4 months postoperatively. Further assessments were made of the site, stage, concentration of c-terminal crosslinked telopepide of type 1 collagen, and actinomycosis. Among the total of 34 patients, 26 (77%) showed complete resolution, 6 (18%) had delayed resolution, and 2 (6%) showed no resolution. There was a significant association between the response to treatment and the stage of BRONJ (p=0.002) but no other significant associations were detected. This study has shown that it is feasible to use L-PRF for the treatment of BRONJ, but the effectiveness cannot be judged with this study design. Randomised prospective trials are needed to confirm this.

Topics: Actinomycosis; Aged; Biopsy; Bisphosphonate-Associated Osteonecrosis of the Jaw; Blood Platelets; Collagen Type I; Debridement; Feasibility Studies; Female; Fibrin; Follow-Up Studies; Humans; Leukocytes; Mandibular Diseases; Maxillary Diseases; Middle Aged; Peptides; Pilot Projects; Prospective Studies; Therapeutic Irrigation; Treatment Outcome; Wound Healing

Solitary maxillary or mandibular bone cysts are rare benign lesions. They are usually localized in the mandible of young men. In some cases, a traumatic risk factor can be documented.. A young 13-year-old female patient consulted in the orthodontics unit. An orthopantomogram showed a large cystic lesion in the ramus and posterior part of the left mandible corpus. No reossification of the cavity was observed one year after curettage. A second curettage was performed combined with PRF filling. Six months later, the cavity was completely reossified.. Curettage is the first line treatment of isolated cystic lesions and generally followed by complete reossification of the cavity. Incomplete healing is observed in 20% of the cases. PRF may induce the healing of non-reossified cystic cavity by supplying local growth factors.

Topics: Adolescent; Blood Platelets; Curettage; Female; Fibrin; Humans; Jaw Cysts; Mandibular Diseases; Osteogenesis; Reoperation; Wound Healing

Two cases of central giant cell granuloma were studied ultrastructurally. The majority of vessels showed intravascular fibrin thrombi and endothelial cell damage, with gaps in their walls. Plasma, red cells and fibrin were seen subendothelially. The basal lamina was absent from endothelial cells where these components were in contact with their plasma membrane; otherwise it showed multiplication. It is suggested that the absence of basal lamina is the result of degeneration and that these vessels are probably venules and capillaries rather than lymphatics. Myofibroblasts were the dominant stromal cells. Giant cells had little phagocytic activity. It seems that the main function for the stromal cells is the repair of the haematoma and the damaged vessels. It is proposed that the term giant cell reparative granuloma is appropriate, but it should not be used indiscriminately for all jaw lesions containing giant cells.

Topics: Adult; Aged; Basement Membrane; Endothelium, Vascular; Female; Fibrin; Fibroblasts; Granuloma, Giant Cell; Humans; Macrophages; Mandible; Mandibular Diseases; Terminology as Topic; Thrombosis; Venules