fibrin and Lung-Diseases--Obstructive

The concentration of soluble fibrinogen derivatives (SFD) and protease and procoagulant activities were determined in cell-free supernatants of equine respiratory secretions obtained from horses with chronic pulmonary disease. The concentration of neutrophils was estimated from direct smears of the secretions. Lung specimens and smears of the secretions were evaluated for the presence of fibrin or fibrinogen by use of immunohistochemical methods. Thirty-five of 80 specimens tested contained SFD. Respiratory secretions from horses with moderate or severe chronic pulmonary disease contained SFD more frequently than did secretions from mildly affected horses (P less than 0.05). Respiratory secretions with vast numbers of neutrophils had significantly (P less than 0.05) higher SFD concentrations than respiratory secretions with fewer neutrophils. Protease and procoagulant activities in respiratory secretion specimens were positively correlated with neutrophil content, clinical diagnosis, and SFD concentration. Immunohistochemically, macrophages that stained for fibrin or fibrinogen were observed in direct smears of respiratory secretions from horses with moderate and severe chronic small airway disease, but not in smears from mildly affected horses. Fibrin or fibrinogen was detected in a few thickened alveolar septa from 10 horses with moderate or severe chronic small airway disease, but not in lungs from horses with mild or no evidence of chronic small airway disease. Fibrin or fibrinogen was detected in alveolar septa, granulomas, and on alveolar macrophages in lungs of all horses with chronic granulomatous and chronic bronchointerstitial pneumonia. The presence of SFD in equine respiratory secretions may be an indicator of pulmonary inflammation.

Topics: Animals; Endoscopy; Fibrin; Fibrinogen; Horse Diseases; Horses; Immunodiffusion; Immunoenzyme Techniques; Lung; Lung Diseases, Obstructive

Progression of intermittent partial or total impaction of the poppet from a prosthetic mitral valve may be difficult to evaluate in patients with chronic obstructive pulmonary disease and atrial fibrillation. Heart sounds may be distant; opening and closing clicks of the poppet are muffled and irregular. Echocardiography provides a noninvasive method to detect early prosthetic malfunction at a time when the patient is clinically asymptomatic.

Topics: Atrial Fibrillation; Blood Coagulation Disorders; Echocardiography; Fibrin; Heart Valve Prosthesis; Hemodynamics; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Mitral Valve

Topics: Adolescent; Adult; Antigens; Fibrin; Fibrinogen; Fibrinolysis; Humans; Lung Diseases, Obstructive; Male; Physical Exertion; Swimming

Topics: Angiography; Animals; Antifibrinolytic Agents; Blood Cell Count; Blood Coagulation Tests; Blood Platelets; Disease Models, Animal; Disseminated Intravascular Coagulation; Epinephrine; Fibrin; Fibrinogen; Fibrinolysis; Glass; Immune Sera; Kidney; Lactates; Liver; Lung; Lung Diseases, Obstructive; Male; Platelet Adhesiveness; Rats; Serum Globulins; Spleen; Thrombelastography

Topics: Blood Coagulation Factors; Carbon Dioxide; Disseminated Intravascular Coagulation; Fibrin; Fibrinolysis; Humans; Immunodiffusion; Lung Diseases, Obstructive; Oxygen; Pulmonary Embolism; Respiratory Insufficiency; Time Factors

Topics: Arrhythmias, Cardiac; Burns; Diabetic Coma; Fibrin; Fibrinogen; Heart Failure; Humans; Intensive Care Units; Lung Diseases, Obstructive; Myocardial Infarction; Poisoning; Shock, Cardiogenic; Tetanus