fibrin and Leukemia--Myeloid--Acute
fibrin has been researched along with Leukemia--Myeloid--Acute* in 17 studies
Other Studies
17 other study(ies) available for fibrin and Leukemia--Myeloid--Acute
Article | Year |
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An idiopathic skin eruption resembling a butterfly rash in a septic patient with disseminated intravascular coagulation following bone marrow transplantation.
A 31-year-old man who underwent chemotherapy and bone marrow transplantation to treat acute myeloblastic leukemia was admitted to our department complaining of high fever and hypotension. His physical examination revealed warm shock state, eruptions resembling that seen in systemic lupus erythematosus on his face and cyanosis in his fingers. We diagnosed septic shock and idiopathic skin eruption on his face. Following treatment with blood transfusion, anticoagulant, antibiotics, respirator and continuous arteriovenous hemofiltration and dialysis, the patient's condition gradually improved. The eruptions on his face first observed at admission progressed with a worsening of his disseminated intravascular coagulation (DIC), and subsided with an improvement in his DIC. A biopsy of the eruption was taken and pathological findings of the eruption revealed multiple micro-fibrin depositions of the dermis. The skin necrosis in purpura fulminans often begins in the distal extremities. But our patient developed this uncommon skin eruption on his face. Patients with an idiopathic skin eruption resembling a butterfly rash in a septic patient should be considered to complicate DIC as in the present case. Topics: Adult; Bone Marrow Transplantation; Disseminated Intravascular Coagulation; Exanthema; Face; Fibrin; Humans; IgA Vasculitis; Leukemia, Myeloid, Acute; Male; Necrosis; Sepsis | 2004 |
[Bilateral retinal hemorrhages with a white center. "White centered hemorrhages" in acute myeloid leukemia].
Topics: Adult; Blood Platelets; Diagnosis, Differential; Fibrin; Humans; Leukemia, Myeloid, Acute; Leukocytes; Male; Retinal Hemorrhage | 2001 |
[Detection of factor XIII deficiency in acute leukemia with resonance thrombography].
In 16 patients affected with acute leukemia (7 patients with acute lymphatic leukemia and 9 patients with acute myeloid leukemia) the resonance thrombogramme was recorded during cytostatic induction therapy, coagulation factor XIII (subunit XIII-A, XIII-S) and further hemostasiological parameters were determined. Subunit XIII-A was lowered to 36%, subunit XIII-S to 65% and the fibrin formation time of the resonance thrombogramme was extended to 9 minutes. There exists a negative correlation between component XIII-A and fibrin formation time r = -0.48 (p less than 0.01). The influence exerted by diminishing factor XIII and fibrin(ogen) splitting products on the fibrin formation time was investigated in in-vitro tests. A diminution of factor XIII below 10% will extend the fibrin formation time to about 10 minutes, an increase of fibrin(ogen) splitting products to 100 micrograms/ml to about 3 minutes. Topics: Adult; Aged; Blood Coagulation Tests; Factor XIII; Factor XIII Deficiency; Fibrin; Fibrin Fibrinogen Degradation Products; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Middle Aged | 1987 |
Rapid growth of human cancer cells in a mouse model with fibrin clot subrenal capsule assay.
Rapid in vivo growth of cultured human cancer or leukemia cells was achieved by implantation into the subrenal capsule of mice. A solid structure, necessary for accurate implantation and measurement of tumor growth in this model, was provided by stepwise addition of fibrinogen and thrombin to the tumor cells, leading to rapid enzymatic formation of a solid tumor-fibrin matrix. Human leukemia and epithelial cancers increased in volume between 6- and 40-fold when measured 6-10 days after implantation into normal or immunosuppressed mice. Immunosuppression of host CD-1 mice was achieved by cyclosporine given daily after tumor implantation, cyclophosphamide given preimplantation combined with cyclosporine, or whole-body irradiation given preimplantation. Confirming the validity of tumor measurements, tumor histology in the immunosuppressed mice revealed cell proliferation, invasion, and neovascularization. Similarly, no artifactual measurement of tumor growth was observed by nonviable cancer cells, implanted after in vitro exposure to a known cytotoxic concentration of thiotepa. This model provides an economical, short-term technique for the in vivo study of human tumor growth, for the evaluation of new cancer therapies, and for in vitro - in vivo drug activity correlations in specific types of human cancer or leukemia cell lines. Topics: Animals; Colonic Neoplasms; Female; Fibrin; Humans; Immunosuppression Therapy; Karyotyping; Kidney; Leukemia, Myeloid, Acute; Melanoma; Methods; Mice; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous; Urinary Bladder Neoplasms; Vulvar Neoplasms | 1987 |
Fibrinogen--proteolysis in acute myelogenous leukemia (AML).
Fibrinopeptides were measured as direct indices of thrombin, plasmin and elastase in plasma samples obtained from patients with AML. Peptide patterns observed were consistent with spontaneous or drug induced plasmin-specific fibrinogenolysis (AML FAB M 1/3), elastase mediated proteolysis (AML FAB M 3/4) or DIC (AML FAB 4/5). DIC was also observed in septic, agranulocytotic patients. Topics: Adult; Fibrin; Fibrinogen; Fibrinolysin; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Pancreatic Elastase; Thrombin | 1986 |
[Significance of fibrinopeptide A as an indicator for coagulative analysis in thrombotic diseases].
This study was made to know the significance of fibrinopeptide A(FPA) as an indicator for coagulative analysis in thrombotic diseases. In normal control subjects (n=21), values of FPA by the radioimmunoassay were 0.5 +/- 1.4 ng/ml (mean +/- SD). In animal models, using Lyoplastin (tissue thromboplastin, n=5) or Ancrod (n=5) to piglets, plasma FPA levels elevated rapidly as a reflection of fibrin formation, and these changes of FPA were found to be most rapid and sensitive among the indicators for coagulation and fibrinolysis. In patients with thrombosis (n=32), elevated FPA levels (14.7 +/- 13.8 ng/ml) and beta-thromboglobulin (beta-TG)(86.1 +/- 65.6 ng/ml) were found. FPA levels in these patients positively correlated to beta-TG (r=0.5539, P less than 0.05) and inversely to fibrinogen (fbg) (r= -0.3622, P less than 0.05). In patients with acute myelocytic leukemia (AML, n=112), acute promyelocytic leukemia (APL, n=18) and acute lymphocytic leukemia (ALL, n=15), mean FPA levels in patients with active signs and symptoms were significantly higher (AML: 13.5 ng/ml, APL: 20.8 ng/ml, ALL: 12.4 ng/ml) than those examined during remission states (AML: 7.7 ng/ml, P less than 0.02, APL: 3.9 ng/ml, P less than 0.01, ALL: 2.7 ng/ml, P less than 0.01). FPA levels in patients with APL inversely correlated to fbg (r= -0.6399, P less than 0.01). In patients with lung cancer (n=75), mean FPA level in advanced stage (17.7 ng/ml, n=67) were significantly higher than those examined in early stage 6.5 ng/ml, n=8, P less than 0.001). In patients with acute disseminated intravascular coagulation (n=12), prolonged prothrombin time and activated partial thromboplastin time, severely reduced fbg and platelets, and remarkably elevated fibrin degradation product were found. Elevated FPA and beta-TG levels were also found (FPA: 23.5 +/- 15.0 ng/ml, beta-TG: 100.0 +/- 63.0 ng/ml). In five patients with thrombotic diseases who were treated successfully with 12500 IU of heparin per 12 hours (subcutaneous injection), plasma FPA levels were reduced to near normal levels quicker than changes of other indicators. These clinical and experimental data suggested that FPA was an useful indicator for active coagulation process. Topics: Adult; Animals; Blood Coagulation; Disseminated Intravascular Coagulation; Female; Fibrin; Fibrinogen; Fibrinopeptide A; Heparin; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lung Neoplasms; Male; Radioimmunoassay; Swine; Thrombosis | 1982 |
Morphology of fibrin in disseminated intravascular coagulation (DIC).
Topics: Disseminated Intravascular Coagulation; Fibrin; Fibrinogen; Humans; Leukemia, Myeloid, Acute; Microscopy, Electron, Scanning | 1978 |
[Disseminated intravascular coagulation in blastic leukemia and certain other disorders].
Topics: Acute Disease; Antithrombins; Blood Cell Count; Blood Coagulation Tests; Disseminated Intravascular Coagulation; Fibrin; Fibrinogen; Fibrinolysis; Hemorrhage; Humans; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Liver Cirrhosis; Lymphatic Diseases; Platelet Adhesiveness; Prothrombin Time; Retinal Detachment; Thrombin; Thrombophlebitis | 1974 |
Factor XIII-activity and fibrin subunit structure in acute leukemia.
Topics: Adolescent; Adult; Aged; Blood Cell Count; Blood Platelets; Blood Protein Electrophoresis; Electrophoresis, Polyacrylamide Gel; Factor XIII Deficiency; Female; Fibrin; Fibrinogen; Hematocrit; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Middle Aged; Thrombelastography | 1974 |
[The importance of soluble fibrinomeric complexes and fibrin degradation products in the differential diagnosis of fibrinogenopenia in blastic leukemia].
Topics: Afibrinogenemia; Diagnosis, Differential; Fibrin; Humans; Leukemia, Myeloid, Acute | 1973 |
Platelet function in acute leukemia.
Topics: Acute Disease; Adenine Nucleotides; Adenosine Diphosphate; Adult; Aged; Blood Platelets; Collagen; Epinephrine; Female; Fibrin; Humans; Kaolin; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Middle Aged; Muramidase; Platelet Adhesiveness; Remission, Spontaneous; Thrombin | 1972 |
Acute promyelocytic leukemia with disseminated intravascular coagulation.
Topics: Adolescent; Adult; Blood Coagulation Disorders; Bone Marrow; Brain; Disseminated Intravascular Coagulation; Female; Fibrin; Fibrinogen; Hemorrhage; Humans; Kidney Glomerulus; Leukemia, Myeloid, Acute; Liver; Lymph Nodes; Male; Middle Aged; Pulmonary Edema; Skin; Spleen | 1971 |
One- and two-stage factor VIII-activity in acute leukaemia.
Topics: Adolescent; Adult; Blood Cell Count; Blood Coagulation Tests; Blood Platelets; Factor VIII; Female; Fibrin; Hemolysis; Humans; Leukemia, Myeloid, Acute; Male; Methods | 1970 |
Activated coagulation factors: in-vivo and in-vitro studies.
Topics: Blood Coagulation Factors; Blood Coagulation Tests; Factor VIII; Fibrin; Heparin; Humans; In Vitro Techniques; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Thrombin; Thromboplastin | 1969 |
The ultrastructure of the cryofibrinogen in acute promyelocytic leukemia displaying the defibrination syndrome and fibrillar inclusions in promyelocytes.
Topics: Acute Disease; Blood Coagulation Disorders; Blood Platelets; Bone Marrow; Bone Marrow Cells; Cold Temperature; Endoplasmic Reticulum; Female; Fibrin; Fibrinogen; Humans; Leukemia, Myeloid, Acute; Microscopy, Electron | 1969 |
Hypofibrinogenaemia in acute leukaemia with extensive fibrinous pericarditis.
Topics: Adolescent; Afibrinogenemia; Blood Coagulation Disorders; Bone Marrow Cells; Cardiac Tamponade; Factor V Deficiency; Factor VIII; Fibrin; Hemorrhagic Disorders; Humans; Leukemia, Myeloid, Acute; Male; Pericarditis; Pericardium; Staining and Labeling | 1967 |
Fibrinogenopenia and fibrinolysis in acute myelogenous leukemia.
Topics: Afibrinogenemia; Fibrin; Fibrinogen; Fibrinolysis; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute | 1955 |