fibrin and Intermittent-Claudication

fibrin has been researched along with Intermittent-Claudication* in 8 studies

Reviews

1 review(s) available for fibrin and Intermittent-Claudication

ArticleYear
Controlled defibrination in the treatment of peripheral vascular disease.
    Angiology, 1978, Volume: 29, Issue:1

    Topics: Ancrod; Animals; Arteriosclerosis; Blood Viscosity; Disease Models, Animal; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinogen; Humans; Intermittent Claudication; Thrombophlebitis; Vascular Diseases

1978

Other Studies

7 other study(ies) available for fibrin and Intermittent-Claudication

ArticleYear
Regarding "Altered fibrin clot structure and function in individuals with intermittent claudication".
    Journal of vascular surgery, 2009, Volume: 49, Issue:4

    Topics: Blood Coagulation; Cardiovascular Diseases; Family; Fibrin; Genetic Predisposition to Disease; Humans; Intermittent Claudication; Pedigree; Peripheral Vascular Diseases; Prognosis; Risk Factors

2009
Altered fibrin clot structure and function in the healthy first-degree relatives of subjects with intermittent claudication.
    Journal of vascular surgery, 2008, Volume: 48, Issue:6

    Studies report clustering of cardiovascular risk factors and increased cardiovascular events in healthy first-degree relatives (FDR) of subjects with intermittent claudication (IC). Family history is an independent risk factor in coronary artery disease but the role of genetic factors is undefined in peripheral arterial disease. The fibrin clot is the final product of the atherothrombotic process and is subject to genetic influence. We proposed that healthy male FDR of subjects with IC possess abnormalities in their fibrin clots.. This was a case-control family study. The FDR were recruited from claudicants attending vascular surgery out-patient clinics with the control subjects being recruited from the local primary care register. A total of 106 white European male FDR of male subjects with IC were age matched with 107 white European male control subjects from an identical geographic area. The control subjects had no FDR with a history of symptomatic cardiovascular disease, and subjects from both groups were free from a personal history of symptomatic cardiovascular disease or diabetes mellitus. Ex vivo assays for fibrin clot permeation, fiber thickness, factor XIII cross-linking activity, and fibrinolysis were performed on the plasma of the above subjects. In addition, linear regression analysis was undertaken to determine factors associated with clot parameters.. For controls and FDR, respectively, fiber thickness by turbidity was 0.75 (0.67-0.93) vs 0.86 (0.75-0.98) (P < .001), and FXIII cross-linking activity was 105% (87-141) vs 133% (103-155) (P < .001). On confocal microscopy, fibers measured 315.8 (307.0-324.6) vs 405.1 (397.6-412.6) nm (P < .001), and lysis front velocity was 12.66 (6.38-18.94) vs 4.83 (2.50-7.17), mum/min (P = .018). Linear regression analysis revealed cholesterol was associated with changes in certain clot parameters.. The healthy FDR of subjects with IC produce clots which have thicker fibers, increased cross-linking, and resistance to fibrinolysis when compared to controls. This supports the potential genetic basis of peripheral arterial disease and highlights that cholesterol may contribute to this abnormal structure. This suggests that the FDR of subjects with IC, an apparently healthy sub-group of the population, have an elevated cardiovascular risk associated with abnormalities in their clot structure.

    Topics: Adult; Aged; Blood Coagulation; Case-Control Studies; Family; Fibrin; Genetic Predisposition to Disease; Genotype; Humans; Intermittent Claudication; Male; Microscopy, Confocal; Middle Aged; Polymorphism, Genetic; Prognosis; Risk Factors

2008
Exercise in claudicants is accompanied by excessive thrombin generation.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2003, Volume: 26, Issue:2

    exercise in IC leads to ischaemia-reperfusion injury of leg muscles and a systemic inflammatory response, but the effect of on coagulation is unknown.. to compare the effect of exercise on thrombin formation and fibrin turnover in patients with IC (n = 10), and age and sex matched smokers ([S] n = 5) and non-smokers ([NS] n = 5) without peripheral vascular disease.. blood was taken from subjects 60 and 30 min before, and 1, 5, 20, 40, 60 and 120 min after, treadmill exercise. Markers of thrombin generation (thrombin-antithrombin complexes [TAT] and prothrombin fragments 1 + 2 [PF1 + 2]) and fibrin turnover (D-dimer and fibrin degradation products [FbDP]) were assayed at each time point.. following exercise, thrombin generation was significantly greater in the claudicant group compared to the control groups (Area Under Curve [AUC] post exercise IC vs S vs NS; TAT 3960 vs 1623 vs 1476 vs = 0.007 Kruskal-Wallis [KW]; PF1 + 2 163 vs 107 vs 123 p = 0.024 KW). Pre and post-exercise, fibrin turnover in claudicants was similar to smoking controls, but higher than non-smoking controls. (AUC post exercise IC vs NS; D-dimer 6340 vs 2754 p = 0.055 Mann-Whitney U[MW]; FbDP 45113 vs 21511 p = 0.009 MW).. when compared to non-claudicants, exercise in IC is associated with excessive production of thrombin. Despite this, claudicants have a similar level of fibrin turnover suggesting a possible defect in fibrinolysis. This prothrombotic state may contribute to the excess thrombotic morbidity and mortality suffered by claudicants.

    Topics: Aged; Exercise; Fibrin; Fibrinolysis; Humans; Intermittent Claudication; Male; Middle Aged; Smoking; Thrombin

2003
Hemostasis and fibrinolysis in patients with intermittent claudication: effects of prostaglandin E1.
    Prostaglandins, leukotrienes, and essential fatty acids, 2000, Volume: 63, Issue:5

    There is evidence that the coagulation system is activated in patients with peripheral arterial occlusive disease (PAOD). The beneficial effects of the vasoactive drug prostaglandin E1 (PGE1) may rely in part on the modulation of the coagulation system. The study was designed to evaluate the effects of PGE1 on hemostatic and fibrinolytic variables in patients with intermittent claudication. Therefore molecular markers of thrombin (prothrombin fragment 1+2, PTF 1+2; thrombin-antithrombin III complexes, TAT) and fibrin formation (fibrinopeptide A, FPA) and markers of the fibrinolytic activity (fibrin degradation products, D-dimers) were determined before and immediately after the first PGE1 dose (60 microg in 100 ml NaCl over 2 h i.v.) as well as after 4 weeks of daily infusion therapy in 12 PAOD patients and in eight control patients before and after a single placebo infusion. Plasma levels of PTF1+2, TAT, FPA and D-dimers tended to decrease after the initial dose of PGE1. Infusion therapy with PGE1 for 4 weeks led to a decrease of all hemostatic and fibrinolytic parameters with most pronounced changes for PFT1+2, D-dimers and plasminogen activator inhibitor-1 decreasing by 11% (P<0.05), 20% (P<0.05), and 7% (P<0.05), respectively. These variables remained unchanged in controls with placebo infusion. In summary, infusion therapy with PGE1 in patients with PAOD reduces thrombin formation and results in a decrease of fibrin degradation. PGE1 may thus reduce fibrin deposition involved in the pathogenesis of atherosclerosis.

    Topics: Aged; Alprostadil; Antithrombin III; Arterial Occlusive Diseases; Case-Control Studies; Dimerization; Fibrin; Fibrinolysis; Fibrinopeptide A; Hemostasis; Humans; Intermittent Claudication; Male; Middle Aged; Peptide Hydrolases; Placebos; Plasminogen Activator Inhibitor 1; Prothrombin; Thrombin; Time Factors

2000
Relation of haemostatic, fibrinolytic, and rheological variables to the angiographic extent of peripheral arterial occlusive disease.
    International angiology : a journal of the International Union of Angiology, 1995, Volume: 14, Issue:3

    We investigated the relationships between the angiographic severity of peripheral arterial occlusive disease (PAOD) and haemostasis, fibrinolytic, and rheological variables in 219 patients with symptomatic peripheral arterial occlusive disease (PAOD). White cell count, fibrinogen, cross-linked fibrin degradation products (FDP), von Willebrand factor, and plasminogen activator inhibitor levels were all elevated in comparison with age-matched population controls (all p < 0.0001, Mann-Whitney U test), while fibrinogen (Spearman r = 0.30), von Willebrand factor (r = 0.40), and log (FDP) (r = 0.56), (all p < 0.0001) showed a strong correlation with the angiographic extent of PAOD. Multivariate analysis indicated that log (FDP) was a strong independent predictor of the angiographic severity of PAOD (p < 0.0001), in addition to increasing age (p < 0.0001), presence of tissue sepsis (p < 0.02), prior vascular surgery (p = 0.007), and other vascular pathology (p = 0.007). These results confirm that increases in fibrinogen, von Willebrand factor, plasminogen activator inhibitor and fibrin turnover, are strongly associated with the presence of symptomatic peripheral arterial disease, and suggest that there may be causal link between fibrin turnover, as determined by FDP levels, and the extent of peripheral arterial occlusive disease.

    Topics: Age Factors; Aged; Angiography; Arterial Occlusive Diseases; Blood Coagulation Factors; Blood Coagulation Tests; Female; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinogen; Fibrinolysis; Hemostasis; Humans; Intermittent Claudication; Ischemia; Leg; Male; Middle Aged; Reference Values; Rheology

1995
Percutaneous angioplasty, endothelial markers, and fibrin turnover.
    Journal of endovascular surgery : the official journal of the International Society for Endovascular Surgery, 1994, Volume: 1

    A number of thrombotic mediators have been related to peripheral arterial disease in both epidemiological and pathological studies.. We measured preoperative levels of fibrinogen, cross-linked fibrin degradation products (FDP), and the endothelial markers, von Willebrand factor (vWF), tissue plasminogen activator (tPA), and plasminogen activator inhibitor (PAI), in the venous blood of 43 claudicants undergoing percutaneous transluminal angioplasty (PTA). Samples were repeated 4 months later, and changes in the levels of thrombotic mediators were compared with ten controls undergoing angiography alone. Additional perilesional arterial samples were obtained from 11 of the patients.. Arterial sampling indicated that successful PTA led to an immediate fall in tPA levels and a rise in arterial vWF (p < 0.05), together with a trend toward a significant rise in cross-linked FDP levels. Only the increase in FDP following successful PTA (36 cases) (p < 0.05) was observed in 4-month postangioplasty venous samples, whereas all variables remained unchanged in cases of restenosis (4 patients) and in controls (all comparisons made by Wilcoxon matched pairs test).. These findings suggest that successful PTA in patients with intermittent claudication results in acute endothelial disturbance and increased fibrin turnover at the site of angioplasty and in sustained increases in fibrin turnover (as reflected by FDP levels). The observation that this increase in fibrin turnover is absent in cases of restenosis within 4 months of PTA merits further study to determine whether increases in fibrin turnover are necessary to maintain patency following PTA.

    Topics: Angioplasty, Balloon; Arterial Occlusive Diseases; Constriction, Pathologic; Endothelium, Vascular; Female; Femoral Artery; Fibrin; Fibrin Fibrinogen Degradation Products; Humans; Iliac Artery; Intermittent Claudication; Male; Plasminogen Inactivators; Popliteal Artery; Tissue Plasminogen Activator; von Willebrand Factor

1994
Haemorheological therapy.
    Bibliotheca anatomica, 1977, Issue:16 Pt 2

    Topics: Animals; Blood Viscosity; Clofibrate; Fibrin; Fibrinogen; Humans; Intermittent Claudication; Ischemia; Leg; Rabbits

1977
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