fibrin and Infant--Premature--Diseases

Topics: Adult; Disseminated Intravascular Coagulation; Fibrin; Humans; Hyaline Membrane Disease; Infant, Newborn; Infant, Premature, Diseases; Lung; Organ Size; Pulmonary Atelectasis; Pulmonary Edema; Respiration, Artificial

Topics: Calcinosis; Catheterization, Central Venous; Device Removal; Fibrin; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Male

Of 35 newborn infants who died from an infection 19 had postmortem evidence of massive pulmonary hemorrhage. All but 1 of the 19 had evidence of antimortem formation of intravascular fibrin clots in lung tissue. Seventeen infants had low platelet counts. Of the 11 infants in whom coagulation studies were done, 8 had evidence of disseminated intravascular coagulation (DIC) during life. Vasculitis in the lungs, associated with fibrin clots and hemorrhages, was detected in two infants. It is postulated that sepsis is an important cause of hemorrhage in the newborn, probably as a result of the development of DIC.

Topics: Bacterial Infections; Disseminated Intravascular Coagulation; Escherichia coli Infections; Fibrin; Hemoptysis; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; Klebsiella Infections; Lung; Male

Topics: Adult; Chemical Precipitation; Choroiditis; Diseases in Twins; Endotoxins; Escherichia coli Infections; Extraembryonic Membranes; Female; Fetal Death; Fetal Diseases; Fibrin; Humans; Infant, Newborn; Infant, Premature, Diseases; Obstetric Labor, Premature; Photomicrography; Placenta; Pregnancy; Pregnancy Complications, Infectious; Rupture; Shwartzman Phenomenon