fibrin and Infant--Newborn--Diseases

Topics: Adult; Blood Coagulation Disorders; Fibrin; Fibrinogen; Humans; Infant, Newborn; Infant, Newborn, Diseases; Liver Diseases; Protein Conformation; Sialic Acids

Topics: Blood Coagulation Tests; Disseminated Intravascular Coagulation; Ethanol; Fibrin; Humans; Infant, Newborn; Infant, Newborn, Diseases

Immunofluorescence was performed on lung tissue obtained at necropsy from 18 newborn infants, including five with group B streptococcal (GBS) sepsis, seven with idiopathic respiratory distress syndrome (IRDS), and six control infants who died from other causes. Deposits of C3, IgG, and fibrin were found within hyaline membranes of infants who died with GBS sepsis or IRDS within 48 hours after birth. In some cases C4, factor B, and IgM were also observed. In five infants with IRDS who died more than five days after birth, immunofluorescent lung findings were less common and less intense. Hyaline membranes, attributed to mechanical ventilators and oxygen therapy in two infants who did not have GBS infection or IRDS, were negative for complement and immunoglobulins although fibrin was detected in one specimen. These data suggest that immunologic processes may contribute to the pathogenesis of certain types of acute lung injury, particularly in infants who die from GBS infection or IRDS during the early neonatal period.

Topics: Antigen-Antibody Complex; Complement C3; Fibrin; Fluorescent Antibody Technique; Humans; Immunoglobulin G; Infant, Newborn; Infant, Newborn, Diseases; Lung; Lung Diseases; Respiratory Distress Syndrome, Newborn; Streptococcal Infections; Streptococcus agalactiae

Topics: Anticoagulants; Blood; Blood Coagulation; Blood Coagulation Disorders; Blood Coagulation Tests; Female; Fibrin; Fibrinogen; Humans; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Umbilical Cord

Of 35 newborn infants who died from an infection 19 had postmortem evidence of massive pulmonary hemorrhage. All but 1 of the 19 had evidence of antimortem formation of intravascular fibrin clots in lung tissue. Seventeen infants had low platelet counts. Of the 11 infants in whom coagulation studies were done, 8 had evidence of disseminated intravascular coagulation (DIC) during life. Vasculitis in the lungs, associated with fibrin clots and hemorrhages, was detected in two infants. It is postulated that sepsis is an important cause of hemorrhage in the newborn, probably as a result of the development of DIC.

Topics: Bacterial Infections; Disseminated Intravascular Coagulation; Escherichia coli Infections; Fibrin; Hemoptysis; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; Klebsiella Infections; Lung; Male

Topics: Blood Coagulation Tests; Blood Specimen Collection; Calcium; Disseminated Intravascular Coagulation; Fibrin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kaolin; Peptide Hydrolases; Phosphatidylethanolamines; Snake Venoms; Thrombin

87 newborn infants were studied on their first day of life for defects in the coagulation and fibrinolytic systems. The infants were divided into two diagnostic groups, one with IRDS, the other with mixed neonatal disorders. Factor V, fibrinogen and fibrin/fibrinogen degradation products (FDP) were abnormal more often than any of the other factors examined. The presence or absence of "multiple defects" appeared to depend on the severity of the illness and its ultimate course. Thus 28% of the surviving infants or 85% of those who died had "multiple defects". The pattern of abnormalities did not differ between the infants with IRDS and those with mixed disorders. The "multiple defects" are ascribed to the following mechanisms: (1) impaired synthesis due to vitamin K deficiency and/or liver damage, (2) abnormal proteolytic activity stimulated by tissue damage and causing (a) an activation of the coagulation process (b) activation of the fibrinolytic system, or (c) of both the coagulation and the fibrinolytic systems. Differentiation between these pathways to defective haemostasis are important when deciding upon therapeutic measures in addition to the basic treatment.

Topics: Blood Cell Count; Blood Coagulation; Blood Platelets; Factor V; Factor VIII; Female; Fibrin; Fibrinogen; Fibrinolysis; Hemostasis; Humans; Infant Mortality; Infant, Newborn; Infant, Newborn, Diseases; Male; Plasminogen; Respiratory Distress Syndrome, Newborn; Vitamin K Deficiency

Topics: Antifibrinolytic Agents; Blood Coagulation Tests; Disseminated Intravascular Coagulation; Female; Fibrin; Heparin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male

Topics: Age Factors; Disseminated Intravascular Coagulation; Ethanol; Fibrin; Gels; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases

Topics: Adult; Bone and Bones; Central Nervous System; Female; Fibrin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Placenta; Polyhydramnios; Pregnancy; Respiratory Distress Syndrome, Newborn; Subarachnoid Hemorrhage; Syndrome

Topics: Apnea; Catheterization; Female; Fibrin; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infant, Newborn, Diseases; Parenteral Nutrition; Pulmonary Embolism; Thrombosis

Topics: Disseminated Intravascular Coagulation; Erythrocytes; Fibrin; Fibrinogen; Heparin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Listeria monocytogenes; Listeriosis; Male; Protamines; Prothrombin Time; Thrombin; Time Factors

Topics: Disseminated Intravascular Coagulation; Female; Fetal Death; Fibrin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Liver; Pregnancy; Thromboembolism

Topics: Apgar Score; Fibrin; Humans; Hypoxia; Infant, Newborn; Infant, Newborn, Diseases; Time Factors

Topics: Apgar Score; Birth Weight; Blood Cell Count; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Platelets; Disseminated Intravascular Coagulation; Female; Fibrin; Gestational Age; Humans; Hypothermia; Infant, Newborn; Infant, Newborn, Diseases; Male

Topics: Blood; Blood Coagulation Tests; Blood Platelets; Disseminated Intravascular Coagulation; Female; Fibrin; Fibrinogen; Hematoma; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Infant, Newborn, Diseases; Kaolin; Male; Phosphatidylethanolamines; Plasminogen; Skull; Thrombin

Topics: Autopsy; Blood Pressure; Body Temperature; Delivery, Obstetric; Extraembryonic Membranes; Female; Fetal Death; Fibrin; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, Diseases; Medical History Taking; Necrosis; Pregnancy; Prenatal Care; Time Factors

Topics: Autopsy; Blood Cell Count; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Platelets; Cytopathogenic Effect, Viral; Erythrocytes; Fibrin; Fibrinogen; Hemorrhage; Herpes Simplex; Humans; Infant, Newborn; Infant, Newborn, Diseases; Prothrombin Time

Fifty-two surviving low-birth-weight infants who had low Thrombotest (Owren) results on the first day, together with the same number of matched controls with higher Thrombotest results, were examined for the integrity of their central nervous system. Gross abnormalities were found in 13.5% of the low Thrombotest group compared with 1.9% in the higher group. Minor brain damage syndromes were more common in the low Thrombotest group. The combined brain damage syndromes were 23.1% in the low Thrombotest group compared with 3.8% in the higher group.It is suggested that the causes of the brain damage in the low Thrombotest group are either non-fatal cerebral haemorrhage or intravascular fibrin deposition associated with disseminated intravascular coagulation.

Topics: Birth Weight; Brain Diseases; Cerebral Hemorrhage; Child Development; Child, Preschool; Fibrin; Humans; Hypoprothrombinemias; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intelligence Tests; Intracranial Embolism and Thrombosis; Neurologic Examination; Prognosis

Topics: Abruptio Placentae; Animals; Blood Coagulation; Blood Coagulation Disorders; Female; Fibrin; Fibrinogen; Fibrinolysin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Pregnancy Complications, Hematologic; Rabbits

Of 119 neonates dying after 48 hours of life, 19 (16%) showed disseminated fibrin thromboembolism, a histological condition that is very similar to one form of maternal hypofibrinogenaemia. The incidence is nearly five times that among stillbirths and neonates dying within 48 hours of birth. Most of the mothers had a normal pregnancy, labour, and puerperium. One twin may show the condition while the other survives. It is suggested that the affected infants have either no fibrinolytic mechanism, a defective one, or one which for some unaccountable reason was not brought into action. The antecedent plasma fibrinogen level is likely to have been high in some cases, but a fatal outcome can ensue with normal or low levels. The process was considered to be totally responsible for death in six cases (5%) of the series. Renal tubular hyaline droplets apparently rich in haemoglobin were only encountered in one infant (no. 4) who died from massive bilateral adrenal haemorrhage. In the later part of the neonatal period, the process is liable to be indistinguishable clinically from secondary thrombotic processes, which occurred with almost the same incidence in the present series (14(12%) of 119 cases).

Topics: Adrenal Glands; Autopsy; Esophagus; Fibrin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestine, Small; Liver; Pituitary Gland; Pulmonary Veins; Renal Veins; Stomach; Thromboembolism; Time Factors

Topics: Blood Coagulation Disorders; Fibrin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Thrombocytopenia

Topics: Birth Weight; Blood; Blood Coagulation Factors; Cesarean Section; Female; Fibrin; Hemorrhage; Humans; Immunoelectrophoresis; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Infections; Labor Presentation; Labor, Obstetric; Maternal-Fetal Exchange; Pregnancy; Respiratory Distress Syndrome, Newborn; Time Factors; Umbilical Cord

Topics: Adrenal Cortex Hormones; Afibrinogenemia; Asphyxia Neonatorum; Ecchymosis; Exchange Transfusion, Whole Blood; Fibrin; Hemorrhage; Heparin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Penicillins; Respiration, Artificial

Topics: Blood Transfusion; Child; Factor XIII; Fibrin; Genetics, Medical; Hemorrhagic Disorders; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases