fibrin and Hypothyroidism

fibrin has been researched along with Hypothyroidism* in 2 studies

Other Studies

2 other study(ies) available for fibrin and Hypothyroidism

ArticleYear
Prothrombotic alterations in plasma fibrin clot properties in thyroid disorders and their post-treatment modifications.
    Thrombosis research, 2014, Volume: 134, Issue:2

    Available data on fibrin clot properties and fibrinolysis in hyperthyroidism and hypothyroidism are inconsistent. Our objective was to assess the impact of effective treatment of hyper- and hypothyroidism on fibrin clot characteristics.. In a case-control study, ex vivo plasma fibrin clot permeability (Ks) and efficiency of fibrinolysis were assessed in 35 consecutive hyperthyroid and 35 hypothyroid subjects versus 30 controls. All measurements were performed before and after 3months of thyroid function normalizing therapy.. At baseline, hyperthyroid, but not hypothyroid, patients had lower Ks than controls (p<0.0001). Hyperthyroid and hypothyroid groups compared with controls had prolonged clot lysis time (CLT), and lower rate of D-dimer release from clots (D-Drate) (all p<0.05). The regression analysis adjusted for fibrinogen showed that in hyperthyroid patients, pre-treatment thyroid stimulating hormone (TSH) independently predicted Ks, while thrombin activatable fibrinolysis inhibitor (TAFI) antigen predicted CLT. In hypothyroid individuals a similar regression model showed that TSH independently predicts CLT. After 3months of thyroid function normalizing therapy, 32 (91.4%) hyperthyroid and 30 (85.7%) hypothyroid subjects achieved euthyroidism and had improved fibrin clot properties (all p<0.05), with normalization of Ks in hyperthyroid and lysability in hypothyroid patients.. Both hyper- and mild-to-moderate hypothyroidism are associated with prothrombotic plasma fibrin clot phenotype and restoration of euthyroidism improves clot phenotype. Abnormal fibrin clot phenotype might contribute to thromboembolic risk in thyroid disease.

    Topics: Adult; Case-Control Studies; Female; Fibrin; Fibrin Clot Lysis Time; Fibrin Fibrinogen Degradation Products; Fibrinolysis; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Thrombosis

2014
Global fibrinolytic capacity in patients with subclinical hypothyroidism.
    Endocrine journal, 2005, Volume: 52, Issue:3

    Subclinical hypothyroidism (SH) represents the earliest stages of hypothyroidism but the benefits of detecting and treating SH are not well known. The aim of this study was to evaluate the alterations in global fibrinolytic capacity (GFC), which indicates the overall fibrinolytic activity, in patients with SH. The study group comprised of 15 patients with SH and 15 healthy controls. The GFC was significantly lower in patients with SH than in control group (p<0.002). This result suggests a relative hypercoagulable state in SH.

    Topics: Adult; Female; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinolysis; Humans; Hypothyroidism; Statistics, Nonparametric; Thyrotropin; Thyroxine; Tissue Plasminogen Activator; Triiodothyronine

2005