fibrin and Hodgkin-Disease

fibrin has been researched along with Hodgkin-Disease* in 16 studies

Other Studies

16 other study(ies) available for fibrin and Hodgkin-Disease

ArticleYear
Activation of coagulation and deep vein thrombosis after bone marrow harvesting and insertion of a Hickman-catheter in ABMT patients with malignant lymphoma.
    Bone marrow transplantation, 1996, Volume: 17, Issue:4

    Evidence of activation of coagulation was sought in serial plasma samples from 25 ABMT candidates with malignant lymphoma admitted for bone marrow harvesting: 10 females and 15 males, median age 41 years (range 27-58 years). Nineteen patients had non-Hodgkin's lymphoma (NHL) and six had Hodgkin's disease. Of those with NHL, 14 had high-grade and five low- grade disease. The plasma levels of markers of activation (prothrombin fragment 1 + 2, thrombin-antithrombin complexes, fibrinopeptide A and fibrinmonomers) increased significantly (P < 0.001) in association with harvesting. Except for fibrinopeptide A, the indicators of activation were still significantly elevated 24 h after marrow aspiration. Beta-thromboglobulin, a marker of the platelet release reaction, also increased significantly (P < 0.01). Four out of nine patients in whom a long-term central venous catheter was inserted just after marrow aspiration, developed catheter-related deep vein thrombosis, verified venographically, shortly after harvesting. These results suggest that patient with malignant lymphoma undergoing marrow harvesting develop a hypercoagulable state, and that insertion of a central intravenous catheter immediately after marrow harvesting should be avoided to prevent the development of symptomatic deep vein thrombosis.

    Topics: Adult; Anticoagulants; Antithrombin III; beta-Thromboglobulin; Biomarkers; Blood Coagulation; Bone Marrow Transplantation; Catheterization, Central Venous; Circadian Rhythm; Female; Fibrin; Fibrinolysis; Fibrinopeptide A; Heparin; Hodgkin Disease; Humans; Ilium; Lymphoma; Lymphoma, Non-Hodgkin; Male; Middle Aged; Peptide Fragments; Peptide Hydrolases; Plasminogen Activator Inhibitor 1; Platelet Count; Premedication; Prothrombin; Sternum; Subclavian Vein; Thrombophlebitis; Transplantation, Autologous; Wounds and Injuries

1996
Vascular activation in the histopathogenesis of Hodgkin's disease: potential role of endothelial tissue factor in intravascular thrombosis and necrosis.
    The Journal of pathology, 1993, Volume: 171, Issue:2

    Endothelial cell activation and alterations of intravascular coagulation were investigated in 27 cases of Hodgkin's disease (HD), in five cases of anaplastic large cell lymphoma (ALCL), and in ten reactive lymph nodes. Lymph node sections were immunostained for E-selectin, a molecule present on cytokine-activated endothelial cells; for tissue factor (TF), a cellular initiator of the coagulation cascade; for glycoprotein (gp) II/III, a platelet-specific antigen; and for fibrin. In HD, vascular activation was particularly prominent in the nodular sclerosis subtype, as indicated by a larger number of E-selectin-positive blood vessels (72 +/- 49) compared with mixed cellularity (22 +/- 37). High expression of E-selectin was associated with alterations of intravascular coagulation, as indicated by immunostaining of some vascular endothelial cells for TF, by a higher incidence of intravascular thrombi, and by the extensive presence of areas of fibrin exudation and necrosis. In ALCL, the levels of endothelial cell activation and intravascular coagulation were comparable to those of HD nodular sclerosis. In reactive nodes, some E-selectin-positive blood vessels were observed only in 3/10 cases; immunostaining for TF was not detected on endothelial cells; and alterations of intravascular coagulation were rarely observed.

    Topics: Adolescent; Adult; Aged; Cell Adhesion Molecules; E-Selectin; Endothelium, Vascular; Female; Fibrin; Hodgkin Disease; Humans; Lymph Nodes; Male; Middle Aged; Necrosis; Neoplasm Proteins; Regional Blood Flow; Thromboplastin; Thrombosis

1993
Fibrinogen deposition and macrophage-associated fibrin formation in malignant and nonmalignant lymphoid tissue.
    The Journal of laboratory and clinical medicine, 1992, Volume: 119, Issue:2

    Nonmalignant lymphoid tissue and tissue from patients with nodular sclerosis, Hodgkin's disease, and large cell lymphocytic lymphoma was examined by immunohistochemical techniques for the occurrence in situ of components of coagulation and fibrinolysis reaction pathways. Staining for material interpreted as fibrinogen was observed in abundance in both malignant and reactive lymphoid tissue. Fibrin also occurred to a variable extent but focally in all tissues. Components of coagulation pathways, including tissue factor, factor VII, factor X, and factor XIII ("a" subunit), were restricted to tissue macrophages. Double-labeling techniques revealed fibrin in direct apposition to tissue macrophages. We conclude that fibrinogen and fibrin occur in both benign and malignant lymphoid tissue and that the transformation of fibrinogen to fibrin is attributable to macrophage-initiated thrombin formation. We postulate that both systemic and local hypercoagulability associated with these disorders may be attributable to macrophage activation resulting in expression of procoagulant activity.

    Topics: Adolescent; Adult; Aged; Factor VII; Factor VIII; Factor X; Female; Fibrin; Fibrinogen; Fibrinolysis; Hodgkin Disease; Humans; Immunohistochemistry; Leukemia, Lymphocytic, Chronic, B-Cell; Lymph Nodes; Lymphoid Tissue; Lymphoma, Large B-Cell, Diffuse; Macromolecular Substances; Macrophages; Male; Middle Aged; Sclerosis; Thromboplastin

1992
Fibrinolysis resistant fibrin deposits in lymph nodes with Hodgkin's disease.
    Thrombosis and haemostasis, 1988, Oct-31, Volume: 60, Issue:2

    Extravasal fibrin deposition is frequently observed within and around tumorous tissues and has been implicated in various aspects of tumor growth. However, no adequate information has been available on the mechanism how intratumoral interstitial fibrin deposits escape a prompt elimination by the fibrinolytic system. In this study we provide immunomorphological evidence showing that fibrin deposits in lymph nodes with Hodgkin's disease are stabilized and made resistant to fibrinolysis by factor XIII (FXIII) of blood coagulation. By double immunofluorescent labelling systems fibrin deposits were simultaneously stained for alpha 2-antiplasmin (alpha 2-AP), the main physiological inhibitor of fibrinolysis and in a number of nodular areas they were also labelled for plasmin(ogen). The detection of alpha 2-antiplasmin-plasmin complex-neoantigen (alpha 2-AP-P-Neo) revealed that alpha 2-AP reacted with plasmin, i.e., alpha 2-AP covalently linked to fibrin indeed inhibited intratumoral fibrinolysis. In addition to fibrin deposits FXIII was also found in cellular elements characterized earlier as tumor associated macrophages. These cells were attached to fibrin strands suggesting that they are involved in the intratumoral fibrin formation and might be a source of fibrin stabilizing factor in the tumor stroma.

    Topics: Fibrin; Fibrinolysis; Fluorescent Antibody Technique; Hodgkin Disease; Humans; Lymph Nodes

1988
The evaluation of fibrinogen behavior in Hodgkin's disease: correlation with clinical stage.
    Tumori, 1983, Apr-30, Volume: 69, Issue:2

    Forty-four patients (9 stage II, 15 sage III, 7 stage IV, and 13 in complete remission) with Hodgkin's disease without any clinical coagulation disorder were studied. Fibrinogen behavior was evaluated by measuring fibrinogen level and using 1251-fibrinogen, the half-life, survival and fibrinogen turnover. Platelet count and fibrinogen/fibrin degradation products (FDP) were also assayed. The fibrinogen half-life, survival and turnover were significantly longer and faster, than those found in 10 healthy subjects, in stage II, III and IV subjects (p less than 0.001, p less than 0.001, p less than 0.05 for stage II; p less than 0.001, p less than 0.001, p less than 0.001 for stage III; p less than 0.005, p less than 0.005, p less than 0.001 for stage IV, respectively). In most cases, FDP values were within the normal range, although they were significantly higher than those of control group in stages III and IV. Intravascular coagulation and fibrinolysis were not found in the 13 patients with complete remission. In these patients, the behavior of fibrinogen was normal, suggesting that the parameters studied are related to the presence of the tumor, and can be useful in monitoring the state of remission.

    Topics: Adult; Female; Fibrin; Fibrinogen; Half-Life; Hodgkin Disease; Humans; Male; Middle Aged; Neoplasm Staging; Platelet Count; Prognosis

1983
Fibrin deposits in Hodgkin's disease.
    The American journal of pathology, 1982, Volume: 108, Issue:1

    Fibrin deposits were observed in the involved lymph nodes and/or spleens of 15 patients with Hodgkin's disease by specific immunofluorescence and by electron microscopy. Two basic patterns of fibrin deposition were observed: 1) intercellular deposits, chiefly associated with nonneoplastic-appearing lymphoid cells and 2) deposits associated with the collagen fibers of young connective tissue. In addition, coarse fibrin deposits were observed in areas of necrosis, presumably a non-specific finding. Fibronectin was also observed in intercellular areas, but staining was less intense than for fibrin. Fibrin deposits were also observed in 3 of 6 cases of non-Hodgkin's lymphoma, indicating that the finding is not an exclusive feature of Hodgkin's disease. The pathogenesis and possible significance of fibrin deposition in Hodgkin's disease are related to earlier observations of activation of the coagulation system on neoplasia and cell-mediated immunity and to the possible role of fibrin, fibronectin, and their breakdown products in angiogenesis and fibroplasia.

    Topics: Collagen; Connective Tissue; Fibrin; Fibronectins; Fluorescent Antibody Technique; Hodgkin Disease; Humans; Lymph Nodes; Lymphoma; Microscopy, Electron; Spleen

1982
[Segmental resection of the spleen and glueing with human fibrinogen - an alternative to splenectomy and autotransplantation (author's transl)].
    Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood, 1982, Volume: 35, Issue:4

    Basing on exemplary case histories - trauma, benign tumour and staging of lymphogranulomatosis - the possibility of maintaining the function of splenic tissue by means of partial splenic resection is discussed. Indication, surgical approach including fibrin glueing and postoperative follow-up are described, taking recent literature into account, and are discussed as an alternative to splenectomy and autotransplantation.

    Topics: Child; Fibrin; Hodgkin Disease; Humans; Male; Neoplasm Staging; Splenectomy; Splenic Neoplasms; Splenic Rupture; Tissue Adhesives

1982
The history and progress of serologic immunotherapy and radiodiagnosis.
    Radiology, 1976, Volume: 118, Issue:1

    The early demonstration of immunologic specificity of antibodies and the discovery of tumor antigenic specificity are reviewed in the light of experimental and clinical attempts to use such reagents in the management of cancer. Recent results in regard to tumor antigens and radiolabeled antibody preparations are shown to be practical for experimental diagnosis and therapy and potentially for similar clinical purposes.

    Topics: alpha-Fetoproteins; Animals; Antibodies, Neoplasm; Antigens, Neoplasm; Carcinoembryonic Antigen; Colonic Neoplasms; Europe; Female; Fibrin; Hodgkin Disease; Humans; Immunization, Passive; Immunoglobulin G; Immunotherapy; Iodine Radioisotopes; Isotope Labeling; Male; Mice; Neoplasm Transplantation; Neoplasms; Ovarian Neoplasms; Rabbits; Radionuclide Imaging; Rats; Transplantation, Heterologous; United States

1976
Splenomegaly associated with chronic consumption coagulopathy.
    Acta medica Scandinavica, 1974, Volume: 195, Issue:5

    Topics: Adult; Aged; Chronic Disease; Disseminated Intravascular Coagulation; Factor V; Factor VII; Female; Fibrin; Fibrinogen; Gaucher Disease; Hodgkin Disease; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Middle Aged; Organ Size; Plasminogen; Polycythemia Vera; Prothrombin Time; Spleen; Splenectomy; Splenomegaly

1974
The fibrinolytic enzyme system in haematological malignancy.
    Bibliotheca anatomica, 1973, Volume: 12

    Topics: Adult; Aged; Disseminated Intravascular Coagulation; Fibrin; Fibrinogen; Fibrinolysis; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Middle Aged; Multiple Myeloma; Myeloproliferative Disorders; Plasminogen; Trypsin Inhibitors

1973
[Abdominal lymphogranulomatosis. Case report].
    Zeitschrift fur arztliche Fortbildung, 1971, Jun-15, Volume: 65, Issue:12

    Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Electrophoresis; Female; Fibrin; Hemoglobinometry; Hodgkin Disease; Humans; Lymphocytes; Lymphography; Male; Middle Aged; Retroperitoneal Neoplasms; Sulfobromophthalein

1971
A comparative study of four methods for detecting fibrinogen degradation products in patients with various diseases.
    The New England journal of medicine, 1970, Sep-24, Volume: 283, Issue:13

    Topics: Adult; Agglutination Tests; Arthritis, Rheumatoid; Blood Coagulation; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Coagulation Tests; Contraceptives, Oral; Erythrocytes; False Negative Reactions; False Positive Reactions; Female; Fibrin; Fibrinogen; Fibrinolysin; Fibrinolysis; Hemagglutination Inhibition Tests; Hodgkin Disease; Humans; Immunoassay; Immunodiffusion; Kidney Diseases; Liver Cirrhosis; Lymphoma, Non-Hodgkin; Male; Methods; Middle Aged; Myocardial Infarction; Neoplasms; Plasminogen; Staphylococcus

1970
Natural evolution and pathological alterations of lymphoid cell proteins. Immunochemical characteristics of soluble antigens.
    Clinica chimica acta; international journal of clinical chemistry, 1970, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Agammaglobulinemia; Aged; Albumins; Animals; Antigens; Biological Evolution; Child; Child, Preschool; Fibrin; Goats; Hodgkin Disease; Humans; Immune Sera; Immunodiffusion; Immunoglobulin G; Infant; Infant, Newborn; Leukemia, Lymphoid; Lymphocytes; Lymphoid Tissue; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Middle Aged; Proteins; Solubility; Thymoma; Thymus Gland; Transferrin

1970
[Localization of fibrin in human tumors].
    Arkhiv patologii, 1969, Volume: 31, Issue:7

    Topics: Adenocarcinoma; Adenoma; Adrenal Gland Neoplasms; Breast Diseases; Breast Neoplasms; Female; Fibrin; Fluorescent Antibody Technique; Genital Neoplasms, Female; Hodgkin Disease; Humans; Lymph Nodes; Lymphatic Diseases; Melanoma; Methods; Neoplasms; Neoplasms, Nerve Tissue; Ovarian Neoplasms; Sarcoma; Stomach Neoplasms; Thyroid Neoplasms; Tuberculosis

1969
[Hyperfibrinemia in Hodgkin's disease and in malignant reticular gangliopathies].
    La Presse medicale, 1958, Sep-27, Volume: 66, Issue:66

    Topics: Blood Cells; Fibrin; Hodgkin Disease; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms; Sarcoma

1958
[Blood fibrinogen and fibrinolytic and fibrinogenolytic activity of plasma in Hodgkin's granuloma].
    Il Progresso medico, 1954, May-31, Volume: 10, Issue:10

    Topics: Coagulants; Fibrin; Fibrinogen; Hemostatics; Hodgkin Disease; Humans; Plasma; Thrombolytic Therapy

1954