fibrin and Hepatitis

Topics: Animals; Aorta; Arteriosclerosis; Blood Coagulation; Blood Coagulation Disorders; Blood Vessels; Endocrine Glands; Fibrin; Fibrinogen; Fibrinolysis; Hemorrhage; Heparin; Heparin Antagonists; Hepatitis; Humans; Lipid Metabolism; Lipoprotein Lipase; Liver; Liver Cirrhosis; Stress, Physiological; Thrombin; Thrombosis; Triglycerides

A prospective study of the incidence of post-operative hepatitis was carried out in 417 patients following open-heart surgery. During the observation period 16 (3.8%) patients contracted hepatitis (15 non-A, non-B hepatitis; 1 hepatitis B). Fibrin seal was used intraoperatively in 19 patients; post-operatively there was no evidence of hepatitis in any of these cases. Thus fibrin seal should not be grouped with "high hepatitis-risk" preparations.

Topics: Adhesives; Cardiac Surgical Procedures; Fibrin; Hepatitis; Humans; Postoperative Complications; Prospective Studies

 Patients with cirrhosis may acquire profound changes in haemostasis. Although haemostatic changes in cirrhosis have been extensively studied, most studies were performed in groups of patients with mixed aetiology. As thrombotic events appear more common in some aetiologies of disease, notably non-alcoholic steatohepatitis (NASH) and cholestatic disease, we hypothesized that haemostatic changes might be different across aetiologies..  We studied 109 patients with cirrhosis (31 cholestatic liver disease, 23 NASH, 37 alcoholic liver disease [ALD], 18 viral hepatitis) and 44 healthy controls. Patients with malignancy were excluded. Routine diagnostic tests of haemostasis, thrombin generation assays, fibrin permeability assays and a plasma-based fibrinolytic assay were performed..  All patients had comparable severity of disease according to their Model for End-Stage Liver Disease score (9 [7-11]). Plasma levels of von Willebrand factor were substantially elevated across all aetiologies, with a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 levels comparable to controls. Thrombin generation capacity was elevated in all aetiologies, most profoundly in ALD. Fibrin permeability was decreased in all aetiologies, which was accompanied by elevated fibrinogen levels. Clot lysis times were prolonged in NASH and cholestatic disease. Plasma levels of individual proteins were similarly altered in all aetiologies..  Our in-depth haemostatic profiling of primary, secondary and tertiary haemostasis in a group of patients with Childs-Turcotte-Pugh A/B cirrhosis showed no large differences between aetiologies, and was consistent with a general hypercoagulable profile in patients with mild cirrhosis. These results suggest that patients with cirrhosis have an increased risk of thrombosis, irrespective of their aetiology.

Topics: Aged; Blood Coagulation; Blood Coagulation Tests; Case-Control Studies; Cholestasis; Female; Fibrin; Fibrinolysis; Fibrosis; Hemostasis; Hemostatics; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases, Alcoholic; Male; Middle Aged; Partial Thromboplastin Time; Thrombin

Topics: Diagnosis, Differential; Fibrin; Granuloma; Hepatitis; Humans; Male; Middle Aged; Q Fever

Topics: Biopsy, Needle; Bone Marrow; Diagnosis, Differential; Egypt; Fever of Unknown Origin; Fibrin; Granuloma; Hepatitis; Humans; Liver; Liver Function Tests; Male; Middle Aged; Osteomyelitis; Q Fever; Travel

During a period when screening for hepatitis B surface antigen (HBsAg) was performed by immunodiffusion using dextran-containing agarose gel, a diffuse precipitation (DP) zone was observed when citrate plasma samples were reacted with certain serum specimens. The DP reaction was noted with a significantly larger number of sera from patients with renal disorders, hepatitis, or certain other virus infections than with sera from apparently healthy blood donors, indicating that it was associated with some type of pathological condition. Highly purified fibrinogen used as detector reagent instead of plasma was sufficient to elicit a precipitation zone similar to that of the DP reaction. In the presence of coagulation inhibitors such as heparin, hirudin and antithrombin III the DP reaction was inhibited, suggesting that the precipitation zone represents coagulation. Cross-linked fibrin was demonstrated in the precipitates of DP-positive sera but not in the corresponding zone of a DP-negative serum.

Topics: Blood Coagulation; Factor X; Fibrin; Hepatitis; Humans; Immunodiffusion; Kidney Diseases; Thrombin; Thromboplastin

Liver lesions in 17 patients with serologically diagnosed Q fever are described. A distinctive granulomatous pattern, with granuloma formation plus a fibrinoid ring, was observed in 14 cases. In two cases the fibrinoid material consisted of fibrillar eosinophilic structures without an annular arrangement, interspersed among epithelioid cells. In only one case was a nonspecific granuloma (devoid of fibrinoid material) noted. We conclude that the association of a granuloma with fibrinoid material is highly indicative of Q fever, but serial sections are often necessary to demonstrate this pattern.

Topics: Adult; Aged; Biopsy, Needle; Diagnosis, Differential; Fibrin; Granuloma; Hepatitis; Humans; Liver; Male; Middle Aged; Q Fever

Liver biopsies of sixty patients with different forms of hepatitis and ten control subjects without hepatic disorders were examined by means of direct immunofluorescent methods for the HBsAg, immunoglobulins, fibrin and C3. The presence of fluorescent particles of HBsAg in the cytoplasm of hepatocytes were correlated with the presence of HBsAg in the serum. The fluorescence did not seem specific of histological stage of hepatitis. Immunoglobulins and fibrin were often demonstrated in hepatic sinusoids, especially in chronic aggressive hepatitis. In contrast, C3 is rarely observed.

Topics: Biopsy; Complement C3; Complement System Proteins; Cytoplasm; Epitopes; Fatty Liver; Fibrin; Fibrinogen; Fluorescent Antibody Technique; Hepatitis; Hepatitis B Antigens; Humans; Immunoglobulins; Liver; Liver Cirrhosis; Liver Diseases; Renal Dialysis

Topics: Blood Protein Electrophoresis; Fibrin; Hepatitis; Humans; Liver Cirrhosis; Platelet Aggregation

Topics: Acute Disease; Adult; Aged; Alcoholism; alpha 1-Antitrypsin; Alpha-Globulins; Chronic Disease; Fatty Liver; Female; Fibrin; Fibrinogen; Fibrinolysis; Hepatitis; Humans; Liver Cirrhosis; Liver Cirrhosis, Biliary; Macroglobulins; Male; Middle Aged; Plasminogen

Topics: Adolescent; Adult; Child; Female; Fibrin; Hemorrhagic Disorders; Hepatitis; Humans; Male; Middle Aged

Topics: Anemia, Hemolytic; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Platelets; Blood Transfusion; Child; Diagnosis, Differential; Disseminated Intravascular Coagulation; Factor V; Factor VIII; Fibrin; Fibrinolysis; Hemorrhagic Disorders; Heparin; Hepatitis; Humans; Infections; Pediatrics; Uremia

Topics: Anemia; Anemia, Hypochromic; Biomedical Research; Blood Chemical Analysis; Collagen Diseases; Enzyme Inhibitors; Fibrin; Hemophilia A; Hepatitis; Hepatitis A; Jaundice; Jaundice, Obstructive; Leukemia; Liver Cirrhosis; Multiple Myeloma; Nephritis; Nephrotic Syndrome; Physiology; Purpura; Thrombin; Uremia

Topics: Afibrinogenemia; Aging; Communicable Diseases; Fibrin; Fibrinogen; Fibrinolysis; Hepatitis; Hepatitis A; Humans