fibrin and Hematuria

A 26-year-old male presented with oedema, massive albuminuria and microscopic haematuria. Kidney biopsy revealed enlarged cellular glomeruli infiltrated by polymorphs and eosinophils with focal fibrin deposits along the basement membrane. Microfilariae were seen in the lumen of few glomerular capillaries. Antistreptolysin titre was negative. The absence of other aetiological factors and presence of microfilariae within glomeruli suggests that nephrotic syndrome may be due to a filarial nephritis.

Topics: Adult; Biopsy; Eosinophils; Fibrin; Filariasis; Hematuria; Humans; Kidney Glomerulus; Male; Nephritis; Nephrotic Syndrome

We examined urinary fibrin and fibrinogen degradation product (U-FDP) concentrations in pediatric patients with hematuria using the rapid and highly-sensitive latex particle agglutination test (LPAT), and assessed the value of this test for the localization of the site of hematuria. Patients with hematuria were divided into two groups: 60 with glomerular hematuria and 46 with non-glomerular hematuria. If U-FDP concentrations less than 0.25 microgram/ml are accepted as an indicator of glomerular bleeding, the sensitivity and specificity of localization of glomerular hematuria in the present study were 78% (47/60) and 89% (41/46), respectively. The high U-FDP concentrations observed in patients with non-glomerular hematuria may reflect direct bleeding into the urinary tract. Since all 13 patients with glomerular hematuria and U-FDP concentrations of 0.25 microgram/ml or more had coexistent erythrocyte cylindruria, the U-FDP test seems to be compensated with combined urinalysis for the relatively lower sensitivity. We conclude that a knowledge of U-FDP concentrations by LPAT can be of help in localizing the site of bleeding in hematuria.

Topics: Adolescent; Child; Child, Preschool; Evaluation Studies as Topic; Female; Fibrin; Fibrin Fibrinogen Degradation Products; Hematuria; Humans; Infant; Japan; Latex Fixation Tests; Male; Sensitivity and Specificity

The loin pain hematuria syndrome has been characterized as a constellation of severe recurrent flank pain and hematuria, occurring predominantly in young women. We studied a 17-year-old woman who had recurrent right flank pain, gross hematuria, and fever, without evidence of urinary tract infection. Her physical exam was remarkable for right costovertebral angle tenderness and a normal BP. Her urinalysis showed blood and protein but her creatinine clearance and 24-hour urinary calcium excretion were normal. A kidney biopsy was remarkable for arteriolar subintimal fibrous thickening and fibrin deposition, but no glomerulonephritis. Her peripheral hemostasis evaluation was normal except for circulating platelet aggregates and elevated fibrinopeptide A levels. On two occasions, her serum was unable to normally support prostacyclin (PGI2) production by cultured human umbilical endothelial cells, as measured by radioimmunoassay (RIA) of its stable metabolite 6-keto-PGF alpha. Blood samples from the right renal vein and inferior vena cava revealed a selective elevation of fibrinopeptide A in the right renal venous effluent. The presence of circulating platelet aggregates and elevated levels of fibrinopeptide A (a cleavage product of fibrin) suggests that platelet activation and fibrin deposition may play a role in the pathogenesis of this disorder. The inability of her serum to normally support the production of the potent antiplatelet and antithrombotic substance, PGI2, could represent a primary renovascular endothelial cell defect.

Topics: Adolescent; Epoprostenol; Female; Fibrin; Hematuria; Humans; Kidney; Pain; Platelet Aggregation; Syndrome

The distinction between venomous, potentially dangerous snakes and snakes considered to be harmless to humans is not always clear. A man was bitten by an assumed harmless pet snake, Rhabdophis subminatus (the red neck keelback), that had been obtained from a pet store. The patient experienced a severe coagulopathy with life-threatening hemorrhage unresponsive to transfusion. Since this snake frequently is sold legally in the United States, we wish to alert the medical community to its potential danger and to discuss the pathophysiological mechanism by which the coagulopathy was produced.

Topics: Adult; Animals; Animals, Domestic; Blood Coagulation Disorders; Blood Coagulation Tests; Fibrin; Gastrointestinal Hemorrhage; Hematuria; Humans; Male; Snake Bites

A case is reported of complete obstruction of a solitary kidney induced by epsilon-aminocaproic acid used to treat significant idiopathic bleeding. The pharmacology and complications of epsilon-aminocaproic acid are also reviewed.

Topics: Adult; Aminocaproates; Aminocaproic Acid; Fibrin; Hematoma; Hematuria; Humans; Kidney; Kidney Diseases; Male

Topics: Adolescent; Adult; Blood Platelets; Blood Transfusion; Diagnosis, Differential; Disseminated Intravascular Coagulation; Female; Fibrin; Fibrin Fibrinogen Degradation Products; Hematuria; Hemolytic-Uremic Syndrome; Hemorrhagic Disorders; Heparin; Humans; Male; Melena; Middle Aged; Neurologic Manifestations; Prednisolone; Pregnancy; Pregnancy Complications, Hematologic; Thrombocytopenia

Kidney biopsies from ten children with recurrent macroscopic haematuria, showed mesangial deposition of IgG, IgA and complement. Eight of these ten biopsies also showed disposition of properdin, a basic euglobulin intimately involved in the alternate pathway of complement activation. Serum haemolytic complement activity was normal in the eight patients tested. Incubation of the serum at 4 degrees C for 24 dours did not result in any change in complement activity. Theses data suggest that the mesangial inflammatory process in these patients may be medicated in part by the alternate pathway of complement activation and that the mechanism is activated locally.

Topics: Adolescent; Beta-Globulins; Child; Child, Preschool; Complement System Proteins; Female; Fibrin; Hematuria; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Kidney; Kidney Glomerulus; Male; Properdin; Recurrence; Syndrome

Four patients had clinical manifestations of the hemolytic-uremic syndrome. No evidence of active intravascular coagulation was found during the acute phase of the illness, using a sensitive assay to measure soluble circulating fibrin in the plasma of these patients, three of whom developed the clinical syndrome while hospitalized for gastro-enteritis. These findings, coupled with the findings of others, suggest that either the episode of intravascular coagulation precedes the development of the clinical manifestations, or that platelet thrombosis is occurring in the absence of activation of plasma clotting factors. In any case, heparin anticoagulant therapy does not seem indicated.

Topics: Anuria; Blood Cell Count; Blood Coagulation Tests; Blood Platelets; Blood Pressure; Blood Urea Nitrogen; Carbon Radioisotopes; Child; Child, Preschool; Creatinine; Disseminated Intravascular Coagulation; Factor V; Factor VIII; Female; Fibrin; Fibrinogen; Hematuria; Hemoglobins; Hemolytic-Uremic Syndrome; Heparin; Humans; Infant; Male; Proteinuria; Prothrombin Time; Thromboplastin; Thrombosis

Topics: Acute Kidney Injury; Anemia; Basement Membrane; Blood Coagulation Disorders; Capillaries; Epithelial Cells; Fibrin; Fluorescent Antibody Technique; Glomerulonephritis; Hematuria; Histocytochemistry; Humans; Immunoglobulins; Kidney; Kidney Glomerulus; Kidney Tubules; Microscopy, Electron; Prognosis; Proteinuria; Statistics as Topic

Topics: Aged; Autopsy; Chronic Disease; Disseminated Intravascular Coagulation; Female; Fibrin; Fibrosarcoma; Hematoma; Hematuria; Humans; Leiomyosarcoma; Pulmonary Artery; Sarcoma; Thromboplastin

Topics: Child; Child, Preschool; Female; Fibrin; Fibrinogen; Hematuria; Humans; Infant; Kidney Diseases; Male; Nephritis; Nephrosis; Nephrotic Syndrome; Proteinuria; Purpura; Urinary Tract Infections

Topics: Female; Fibrin; Fibrinogen; Fibrinolysis; Hematuria; Humans; Kidney Diseases; Kidney Pelvis; Male; Prostate; Proteinuria; Ureter; Urethra; Urinary Bladder; Urinary Tract

Topics: Abdomen; Antibodies; Blood Coagulation Tests; Blood Protein Disorders; Chromatography; Cold Temperature; Diagnosis, Differential; Ecchymosis; Electrophoresis; Factor XIII; Female; Fibrin; Fibrinogen; Hematuria; Hemorrhagic Disorders; Humans; Immunoglobulin G; Isoniazid; Middle Aged; Pain; Sarcoidosis

Topics: Fibrin; Fibrinogen; Hematuria; Humans; Kidney Neoplasms; Neoplasm Metastasis; Nephrectomy; Prognosis

Topics: Adolescent; Child; Child, Preschool; Female; Fibrin; Glomerulonephritis; Hematuria; Humans; Hypersensitivity; Immunoglobulin A; Immunoglobulin G; Immunosuppression Therapy; Male; Proteinuria; Purpura; Respiratory Tract Infections; Serum Globulins

Topics: Adult; Basement Membrane; Biopsy; Child; Complement System Proteins; Diagnosis, Differential; Female; Fibrin; Focal Infection; Glomerulonephritis; Hematuria; Humans; Immunoglobulins; Kidney; Kidney Glomerulus; Male; Microscopy, Electron

Topics: Aminocaproates; Blood Coagulation; Blood Coagulation Disorders; Fibrin; Fibrinolysin; Fibrinolysis; Hematuria; Humans; Male; Middle Aged; Urinary Tract; Urinary Tract Infections

Topics: Adolescent; Adult; Arteries; Azaserine; Azathioprine; Basement Membrane; Creatine; Cryptococcosis; Dactinomycin; Epithelial Cells; Female; Fibrin; Fluorescent Antibody Technique; Follow-Up Studies; Graft Rejection; Hematuria; Humans; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Glomerulus; Kidney Papillary Necrosis; Kidney Transplantation; Male; Mercaptopurine; Pneumonia; Prednisone; Proteinuria; Thrombosis; Transplantation Immunology; Transplantation, Homologous

We have investigated the formation of fibrin, platelet aggregates, and subendothelial deposits in lipoid nephrosis. Fibrin formation was found in 10 cases of active lipoid nephrosis. Platelet aggregates were found in eight cases and subendothelial deposits in nine. Fibrin and platelets were also found in cases of nephrotic syndrome due to other causes, and in glomerulonephritis. Fibrin was generally absent in lipoid nephrosis in remission and in benign recurrent hematuria. It is suggested that what seems to be a lower incidence in females is more apparent than real and that fibrin or related material may be present in a less easily identifiable form. Steroid therapy apparently had no effect on the presence or absence of fibrin. Most instances were associated with elevated serum cholesterol and alpha(2)-globulin. It is suggested that elevated serum lipids as well as the disease process in the kidney play a role in this phenomenon. It is further suggested that intraglomerular fibrin formation could lead to irreversible renal damage in lipoid nephrosis.

Topics: Adolescent; Adult; Aged; Alpha-Globulins; Biopsy; Blood Platelets; Child; Child, Preschool; Cholesterol; Chronic Disease; Female; Fibrin; Glomerulonephritis; Hematuria; Histocytochemistry; Humans; Kidney Glomerulus; Male; Microscopy, Electron; Middle Aged; Nephrosis, Lipoid; Nephrotic Syndrome; Sex Factors; Steroids

Topics: Acute Kidney Injury; Anemia, Hemolytic; Anuria; Blood Cell Count; Blood Coagulation Factors; Blood Transfusion; Central Nervous System Diseases; Disseminated Intravascular Coagulation; Erythrocytes, Abnormal; Fibrin; Hematuria; Hemoglobins; Hemolysis; Heparin; Humans; Hyperkalemia; Infant; Kidney; Kidney Glomerulus; Peritoneal Dialysis; Thrombocytopenia

Topics: Adult; Afibrinogenemia; Blood Coagulation Disorders; Female; Fibrin; Fibrinolytic Agents; Hematuria; Humans

Topics: Blood Coagulation; Fibrin; Fibrinolysis; Fibrinolytic Agents; Hematuria; Humans; In Vitro Techniques; Male; Thromboplastin

Topics: Fibrin; Fibrinolysis; Hematuria; Humans; Mass Screening; Streptodornase and Streptokinase; Thrombelastography; Urine

Topics: Aminocaproates; Aminocaproic Acid; Animals; Arteriosclerosis; Fibrin; Fibrinolysis; Glycosuria; Hematuria; Kidney Diseases; Kidney Glomerulus; Pharmacology; Pulmonary Embolism; Rabbits; Rats; Research; Thrombin