fibrin and Hematoma

Topics: Abortion, Spontaneous; Blood; Blood Coagulation Tests; Blood Platelets; Cerebral Hemorrhage; Ecchymosis; Factor XIII; Factor XIII Deficiency; Female; Fetal Death; Fibrin; Hematoma; Hemorrhage; Hemorrhagic Disorders; Humans; Infant, Newborn; Placenta; Pregnancy; Pregnancy Complications, Hematologic; Umbilical Cord

The hematoma that forms between broken fragments of bone serves as a natural fibrin scaffold, and its removal from the defect site delays bone healing. The hypothesis of this study is that the microarchitectural and mechanical properties of the initially formed hematoma has a significant effect on the regulation of the biological process, which ultimately determines the outcome of bone healing. To mimic three healing conditions in the rat femur (normal, delayed, and non-healing bone defects), three different defect sizes of 0.5, 1.5, and 5.0 mm, are respectively used. The analysis of 3-day-old hematomas demonstrates clear differences in fibrin clot micro-architecture in terms of fiber diameter, fiber density, and porosity of the formed fibrin network, which result in different mechanical properties (stiffness) of the hematoma in each model. Those differences directly affect the biological processes involved. Specifically, RNA-sequencing reveals almost 700 differentially expressed genes between normally healing and non-healing defects, including significantly up-regulated essential osteogenic genes in normally healing defects, also differences in immune cell populations, activated osteogenic transcriptional regulators as well as potential novel marker genes. Most importantly, this study demonstrates that the healing outcome has already been determined during the hematoma phase of bone healing, three days post-surgery.

Topics: Animals; Fibrin; Fracture Healing; Fractures, Bone; Hematoma; Osteogenesis; Rats

Topics: Epstein-Barr Virus Infections; Fibrin; Hematoma; Herpesvirus 4, Human; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; T-Lymphocytes

Introduction: The article presents data from literary sources and a statistical analysis of one's own research on the nature, mechanism and prescription of spleen injury in the case of mechanical trauma and the absence of alcohol intoxication. The aim: To study the dynamics of changes in the histological parameters of the spleen injured tissues in case of mechanical trauma depending on the prescription of injury.. Materials and methods: The material of the study was the spleen tissue of 56 males and females aged from 20-60 who died at known and unknown time in the presence and absence of alcohol in the blood. We used histological, histochemical methods, and carried out a statistical analysis of the results.. Results: The obtained results showed that during the mechanical injury of spleen there often developed a capsule and a parenchyma with hematoma in the area of injury. Our records showed that during the first 6 hours after injury, there appeared a hematoma in the center of the injury. Hemolysis of the erythrocyte particles was observed in the center of the hematoma. There were isolated leukocytes and fibrin tissues closer to the edge of the hematoma.. Conclusions: The obtained results indicate that there are several histological changes in the damaged spleen tissues area which directly depend on the time which passed from the moment of injury.

Topics: Adult; Female; Fibrin; Forensic Medicine; Hematoma; Histological Techniques; Humans; Leukocytes; Male; Middle Aged; Spleen; Wounds and Injuries; Young Adult

Forensic imaging technology has rapidly advanced over the past several decades and is gaining increasing significance in medico-legal death investigations. Medical-grade computed tomography (CT) is now routinely used in post-mortem examinations at numerous institutions across the globe. However, the resolution of medical-grade CT is limited and unsuitable when used to depict some smaller anatomical structures or micro-trauma. High-resolution micro-CT offers up to 100× the resolution to overcome this problem but is a very recent addition to the field of forensic radiology. Few studies so far have attempted to validate the results which is an essential prerequisite for it to be used in the criminal justice process as demanded by regulatory bodies. This study directly compares micro-CT images with histology, the current gold standard. Three cases were examined: two larynges from suspected strangulations and one ribcage of a case of fatal child abuse. A strong correlation was observed between histology and micro-CT as the majority of skeletal injuries were identified correctly. This paper discusses the forensic implications of the results and how micro-CT is complementary to histology.

Topics: Adult; Female; Fibrin; Forensic Medicine; Fractures, Bone; Fractures, Cartilage; Hematoma; Humans; Hyoid Bone; Imaging, Three-Dimensional; Infant; Larynx; Necrosis; Osteoblasts; Osteoclasts; Osteocytes; Rib Fractures; Thyroid Cartilage; X-Ray Microtomography

Fracture hematoma formation describes a transitional phase that involves a dynamic and tightly choreographed interaction between the fibrin matrix, cells, and cytokines that guides the ensuing bone repair. Here we propose a novel hypothesis to explain why hematomas in conjunction with critical sized bone defects are prone to differentiate into fibrous tissues, which eventually results in non-unions of the bone. We postulate that certain hematoma qualities are triggers that influence cell biological behaviours and that the release of certain growth factors determines what pattern of remodelling will prevail: intramembranous or endochondral ossification. A detailed characterization of the structural parameters of hematomas will allow researchers to create a microenvironment that aids the migration of mesenchymal stromal cells into the hematoma where, once established, they accelerate the bone healing process. Such a strategy would be particularly useful when faced with the complications arising from large recalcitrant bone defects that often fail to heal naturally.

Topics: Bone and Bones; Bone Regeneration; Bone Transplantation; Fibrin; Fracture Healing; Hematoma; Humans; Mesenchymal Stem Cells; Models, Theoretical; Osteogenesis; Treatment Outcome

Perioperative bleeding is a potentially devastating complication in neurosurgical patients, and plasma fibrinogen concentration has been identified as a potential modifiable risk factor for perioperative bleeding. The aim of this study was to evaluate preconditioning with Crotalus atrox venom (Cv-PC) as potential preventive therapy for reducing perioperative hemorrhage in the rodent model of surgical brain injury (SBI). C. atrox venom contains snake venom metalloproteinases that cleave fibrinogen into fibrin split products without inducing clotting. Separately, fibrinogen split products induce fibrinogen production, thereby elevating plasma fibrinogen levels. Thus, the hypothesis was that preconditioning with C. atrox venom will produce fibrinogen spilt products, thereby upregulating fibrinogen levels, ultimately improving perioperative hemostasis during SBI. We observed that Cv-PC SBI animals had significantly reduced intraoperative hemorrhage and postoperative hematoma volumes compared to those of vehicle preconditioned SBI animals. Cv-PC animals were also found to have higher levels of plasma fibrinogen at the time of surgery, with unchanged prothrombin time. Cv-PC studies with fractions of C. atrox venom suggest that snake venom metalloproteinases are largely responsible for the improved hemostasis by Cv-PC. Our findings indicate that Cv-PC increases plasma fibrinogen levels and may provide a promising therapy for reducing perioperative hemorrhage in elective surgeries.

Topics: Animals; Brain Injuries; Crotalus; Disease Models, Animal; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinogen; Hematoma; Hemorrhage; International Normalized Ratio; Intraoperative Complications; Male; Prothrombin Time; Rats; Rats, Sprague-Dawley; Snake Venoms

The quality of hematomas are crucial for successful early bone defect healing, as the structure of fibrin clots can significantly influence the infiltration of cells, necessary for bone regeneration, from adjacent tissues into the fibrin network. This study investigated if there were structural differences between hematomas from normal and delayed healing bone defects and whether such differences were linked to changes in the expression of IL-1β. Using a bone defect model in rats, we found that the hematomas in the delayed healing model had thinner fibers and denser clot structures. Moreover, IL-1β protein levels were significantly higher in the delayed healing hematomas. The effects of IL-1β on the structural properties of human whole blood clots were evaluated by thrombelastograph (TEG), scanning electronic microscopy (SEM), compressive study, and thrombolytic assays. S-nitrosoglutathione (GSNO) was applied to modulate de novo hematoma structure and the impact on bone healing was evaluated in the delayed healing model. We found that GSNO produced more porous hematomas with thicker fibers and resulted in significantly enhanced bone healing. This study demonstrated that IL-1β and GSNO had opposing effects on clot architecture, the structure of which plays a pivotal role in early bone healing.

Topics: Animals; Biomechanical Phenomena; Blood Coagulation; Disease Models, Animal; Fibrin; Fibrinolysis; Fracture Healing; Hematoma; Humans; Interleukin-1beta; Microscopy, Electron, Scanning; Rats; Rats, Inbred F344; S-Nitrosoglutathione; Thrombosis

This work is concerned with the sequence of events taking place during the first stages of bone fracture healing, from bone breakup until the formation of early fibrous callus (EFC). The latter provides a scaffold over which subsequent remodeling processes will eventually result in successful bone repair. Specifically, some mathematical models are proposed to estimate the time required for (1) the formation immediately after fracture of a fibrin clot, described in terms of a phase transition in a polymerization process, and (2) the onset of EFC which is produced when fibroblasts arising from differentiation of chemotactically recruited mesenchymal stem cells remodel a previous fibrin clot by releasing a collagen matrix over it. An attempt has been made to keep models as simple as possible, so that a explicit dependence of the estimates obtained on relevant biochemical parameters involved is obtained.

Topics: Animals; Bony Callus; Collagen; Fibrin; Fracture Healing; Growth Substances; Hematoma; Male; Mathematical Concepts; Models, Biological; Platelet Activation; Rats; Rats, Sprague-Dawley

The aim of the paper was to perform a chronological assessment of the phenomenon of delayed rupture of the spleen, to assess the phenomenological order about the sub-capsular hematoma transformation to determine the causal relationship with trauma as hypothetical cause of death. 80 cases of blunt trauma with splenic capsular hematoma and subsequent rupture of the spleen were evaluated: 38 had an acute rupture of the spleen, 42 presented a break in days or weeks after the traumatic injury. Time between the traumatic event and delayed rupture of the spleen is within a range of time from one day to more than one month. Data recorded included age, sex, type of trauma, injury severity score, grade of splenic injury, associated intra-abdominal injuries, pathologic specimen evaluation. Immunohistochemical investigation of perisplenic hematoma or laceration was performed utilizing polyclonal antibodies anti-fibrinogen, CD61 and CD68, and showed structural chronological differences of sub-capsular hematoma. Expression of modification and organization of erythrocytes, fibrinogen, platelets and macrophages provides an informative picture of the progression of reparative phenomena associated with sub-capsular hematoma and subsequent delayed splenic rupture. Sub-capsular splenic hematoma dating, which we divided into 4 phases, is representing a task in both clinical practice and forensic pathology.

Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Erythrocytes; Female; Fibrin; Fibrinogen; Forensic Pathology; Hematoma; Hemorrhage; Hemosiderin; Humans; Immunohistochemistry; Lacerations; Macrophages; Male; Middle Aged; Monocytes; Platelet Aggregation; Retrospective Studies; Spleen; Splenic Diseases; Splenic Rupture; Staining and Labeling; Time Factors; Wounds, Nonpenetrating

Oral anticoagulant therapy (OAT) patients have international normalized ratio (INR) safety windows for oral surgery, the lower limit of which is determined by the thromboembolic risk, with the upper limit typically 3.0. We sought to assess whether these limits will also be true with comorbidities that favor bleeding, such as diabetes, liver disease, and chronic renal failure.. The study was designed for 500 consecutive extractions. Patients with an INR greater than 3.0 were switched to heparin and used as controls. The primary outcome was the incidence of bleeding with the need for reoperation, in connection with 3 principal predictors: the INR, reasons for OAT, and comorbidity type. Continuous variables were analyzed using the Mann-Whitney U test and categorical variables using χ2 or Fisher's exact test. Statistical significance was set at P < .05. The reliability of the INR as a bleeding predictor was assessed using receiver operating characteristic (ROC) curves.. Extractions in patients receiving OAT without comorbidities had a success rate of 99.7% against severe bleeding. Despite equivalent INR values, patients with comorbidities had a significantly lower rate (81.3%, P < .001). For these patients, the ROC curve procedure indicated lower INR upper limits, 2.8 for mechanical heart prosthesis subjects and 2.3 for all others. Among the comorbidities, diabetes was associated with the greatest frequency of bleeding (31%) compared with liver disease (15%) and kidney failure (11%).. Patients with comorbidities should be advised to bring their INR within narrower safety windows (upper limit of 2.5 to 2.8 for mechanical prosthesis and 2.0 to 2.3 otherwise) or be switched to heparin. Alternatively, we propose applying to the socket, a platelet-rich growth factor preparation to foster hemostasis.

Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Area Under Curve; Chronic Disease; Diabetes Complications; Female; Fibrin; Follow-Up Studies; Heart Valve Prosthesis; Hematoma; Hemostatics; Heparin; Humans; International Normalized Ratio; Liver Diseases; Male; Middle Aged; Oral Hemorrhage; Postoperative Hemorrhage; Prospective Studies; Renal Insufficiency; ROC Curve; Thromboembolism; Tooth Extraction; Tooth Socket; Treatment Outcome; Young Adult

Brain derived neurotrophic factor (BDNF) has been shown to ameliorate recovery after intracerebral hemorrhage (ICH). The injured brain tissue after ICH is surrounded by hematoma formed from hemorrhage. Fibrin is abundant in hematoma, which could be a binding target for BDNF. In this work, we have fused a fibrin-binding domain (FBD) to BDNF (FBD-BDNF), and results demonstrate that FBD-BDNF has specific binding ability to fibrin and is retained in hematoma. Using the rat ICH model induced by bacterial collagenase, injected FBD-BDNF has been concentrated and retained at the hematoma. FBD has facilitated BDNF to exert targeting neuroprotective effect to the injured brain tissue around the hematoma after ICH. FBD-BDNF has significantly reduced the hemotoma volume, reduced tissue loss, promoted neural regeneration, and improved the rat behavioral performance.

Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Hemorrhage; Delayed-Action Preparations; Disease Models, Animal; Fibrin; Hematoma; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Motor Activity; Nerve Regeneration; Protein Binding; Rats; Rats, Sprague-Dawley; Recovery of Function

A 16-yr-old adult male northern fur seal (Callorhinus ursinus) was found dead in its outdoor pool in November 1995. The animal was maintained at Mystic Aquarium (Mystic, Connecticut, USA) from March 1980 to November 1995. Gross necropsy findings included hemoperitoneum and locally extensive gastric intramural hemorrhage that involved the posterior fundic, antral, and pyloric regions and extended into the duodenum. The gastric mural thickening grossly resembled hemangioma, and the gastric serosa was ruptured at the site of maximal mural expansion. In histologic sections of the stomach, a cribiform network of fibrin, which encompassed numerous variably-sized aggregates of closely packed erythrocytes, markedly expanded the submucosa. No vascular endothelium was identified in serial histologic sections of the expanded gastric submucosa stained with hematoxylin and eosin or immunohistochemically with antibodies to vimentin and Factor VIII-related antigen, establishing an absence of hemangioma. Carstairs' and Weigert's histochemical stains confirmed that the framework expanding the submucosa was fibrin. Although the appearance of the gastric wall resembled hemangioma, a population of neoplastic endothelial cells was not identified within the submucosal expansion of hemorrhage and fibrin, and microscopic evidence was most consistent with the diagnosis of gastric intramural hematoma. This lesion is a rare pathologic event that has not been reported in marine mammals, but one that should be included in diagnostic considerations of hemoperitoneum and gastric mural expansion.

Topics: Animals; Fatal Outcome; Fibrin; Fur Seals; Gastric Mucosa; Gastrointestinal Hemorrhage; Hematoma; Hemoperitoneum; Immunohistochemistry; Male; Stomach; Stomach Diseases

We report the first case in which a fluid-blood interface was identified at autopsy in a patient with acute intracerebral hematoma on anticoagulant therapy. Anticoagulation may be one of the major factors contributing to the production of an intracerebral blood sedimentation level.

Topics: Aged; Anticoagulants; Blood Sedimentation; Blood-Brain Barrier; Brain; Cerebral Hemorrhage; Fibrin; Heart Valve Prosthesis Implantation; Hematoma; Humans; Male; Mitral Valve Stenosis; Postoperative Complications; Warfarin

The masseter and temporalis muscles were investigated ultrastructurally in 2 patients having fibrodysplasia ossificans progressiva (FOP). Results showed atrophy and necrosis of muscle fibres. Both cases contained cartilage which was calcified in the second case and was associated with degenerating chondrocytes. The blood vessels showed various changes, with haematoma formation and large fibrin deposits. Some of the fibrin deposits seen in the second case were surrounded with cartilage. This suggests that the cartilage probably forms as a reaction to an old haemorrhage. It is possible that the effect of the mutant gene found in FOP is on blood vessels rather than the normal regulatory mechanisms of the inducible osteogenic precursor cells. These degenerating blood vessels often result in haemorrhage and fibrin deposits; the fibrosis, cartilage or bone formation are probably secondary changes. Amianthoid fibres found in the tendon of the temporalis muscles of the second case, together with the other changes of fibrosis and cartilage formation, account for the severe restricted mouth opening suffered by these patients.

Topics: Adolescent; Adult; Arterioles; Calcinosis; Capillaries; Cartilage; Female; Fibrin; Fibrosis; Hematoma; Humans; Male; Masseter Muscle; Muscle Fibers, Skeletal; Muscular Atrophy; Mutation; Myositis Ossificans; Necrosis; Temporal Muscle; Tendons; Venules

We report a new case of severe bleeding diathesis due to an acquired inhibitor of fibrin crosslinking. The patient, an 80-year-old woman, was admitted to the hospital for a massive subcutaneous hematoma, with severe anemia requiring red cell transfusion; a subsequent retroperitoneal hematoma developed 2 weeks later. Coagulation studies were normal except for a thromboelastographic pattern suggestive of FXIII deficiency. Clot solubility test was abnormal even after 1:1 mix with normal plasma. Immunochemical studies confirmed the presence of a monoclonal IgG lambda inhibitor directed against FXIII activity (type II FXIII inhibitor). The patient IgG fraction selectively inhibited FXIII transamidating activity but did not inhibit the thrombin-mediated activation of FXIII. The patient was treated with high doses of FXIII concentrate to overcome the inhibitor and immunosuppressive therapy with cyclophosphamide and discharged in good conditions. High doses of commercially available FXIII appear to be a safe and effective method of controlling acute episodes of bleeding in patients with acquired FXIII deficiency.

Topics: Aged; Aged, 80 and over; Cyclophosphamide; Drug Therapy, Combination; Factor XIII; Factor XIII Deficiency; Female; Fibrin; Hematoma; Humans; Immunoglobulin G

In a prospective study, all patients with peptic ulcer bleeding were documented between February 1984 and April 1992. A total of 227 patients were treated by local injection of epinephrine followed by laser application and injection of polidocanol or fibrin tissue adhesive. In five of these patients, intramural hematomas developing at the former bleeding site one to three days after endoscopic treatment were observed. The presenting symptoms were abdominal pain, nausea, and vomiting. The diagnosis was established by endoscopy, abdominal ultrasound, computed tomography, or laparotomy. In four of our five patients, the bleeding site and hematoma were located in the duodenum. All patients suffered from severe underlying diseases, and showed a clear disturbance of coagulation parameters. In three patients, acute pancreatitis occurred concurrently with the hematoma, probably due to obstruction of the papilla of Vater or compression of the pancreas caused by the hematoma.

Topics: Acute Disease; Adult; Aged; Duodenal Diseases; Endoscopy, Gastrointestinal; Epinephrine; Female; Fibrin; Hematoma; Humans; Injections, Intralesional; Male; Middle Aged; Pancreatitis; Peptic Ulcer Hemorrhage; Polidocanol; Polyethylene Glycols; Prospective Studies; Tissue Adhesives

Acute hematomas can appear hypointense on T2-weighted magnetic resonance (MR) images at field strengths as low as 0.35 T. Using Raman spectroscopy to measure blood oxygenation and taking T2 measurements at 2.1 and 9.4 T, the authors examined the relaxation mechanisms acting during deoxygenation, increases in hematocrit, and fibrin-clot formation and retraction. Individual contributions to overall T2 from deoxyhemoglobin and the interactions of water with protein hydration layers in hemoglobin, plasma proteins, and fibrin were measured. Overall T2 values estimated by summing individual relaxation rates were in reasonable agreement with the T2 values of clotted blood. Results suggest that deoxygenation may be most important in T2 shortening, followed by increased hematocrit. T2 shortening from fibrin polymerization was minimal at the field strengths used. Effects of deoxygenation and increasing hematocrit are more sensitive to field strength than fibrin T2 shortening. Effects of fibrin may be more significant at middle and low field strengths.

Topics: Acute Disease; Blood Coagulation; Fibrin; Hematocrit; Hematoma; Hemoglobins; Humans; In Vitro Techniques; Magnetic Resonance Imaging; Oxygen

A standardized injury of the nail cuticle of normal, factor VII and factor VIII deficient dogs was used to study the evolution of the morphological changes occurring within the forming and formed haemostatic plug at the site of vascular injury. The morphological changes occurring were documented by light and transmission electron microscopy (TEM). Randomized measurements were made of the distances between adjacent platelets as a function of platelet interdigitation or compaction and the degree of dilatation of the open canalicular system (OCS) was used as an indicator of the degree of platelet activation. Fibrin deposition was noted both in terms of its location and the point in time at which it first appeared. TEM demonstrated major differences between the factor VIII deficient and the normal and factor VII deficient groups. In the normal animals the intermembrane distance showed noticeable changes with the platelets becoming tightly interdigitated at the time bleeding stopped. During the same period the OCS became dilated. These changes, which were not seen in the factor VIII deficient animals, continued until many platelets lost their intracellular content and became balloon cells or ghosts and fibrinous transformation became prominent. Although those events did occur in the factor VII deficient state, each was delayed and resulted in significant differences between the factor VII and normal animals suggesting that the extrinsic pathway may play an important role in initiating the changes noted. The results suggested that the generation of thrombin and/or factor Xa is essential to promote the initial stabilization of the platelet plug as well as initiating its subsequent consolidation by fibrinous transformation.

Topics: Animals; Blood Platelets; Dogs; Factor VII Deficiency; Fibrin; Hematoma; Hemophilia A; Hemostasis; Humans; Microscopy, Electron; Time Factors; Toes

A case is reported of complete obstruction of a solitary kidney induced by epsilon-aminocaproic acid used to treat significant idiopathic bleeding. The pharmacology and complications of epsilon-aminocaproic acid are also reviewed.

Topics: Adult; Aminocaproates; Aminocaproic Acid; Fibrin; Hematoma; Hematuria; Humans; Kidney; Kidney Diseases; Male

Topics: Animals; Arteries; Aspirin; Blood Flow Velocity; Blood Vessel Prosthesis; Dipyridamole; Endothelium; Fibrin; Forecasting; Hematoma; Humans; Platelet Adhesiveness; Polyethylene Terephthalates; Prosthesis Design; Sutures; Textiles; Thrombosis; Time Factors; Wound Healing

Topics: Aged; Autopsy; Chronic Disease; Disseminated Intravascular Coagulation; Female; Fibrin; Fibrosarcoma; Hematoma; Hematuria; Humans; Leiomyosarcoma; Pulmonary Artery; Sarcoma; Thromboplastin

Topics: Abortion, Spontaneous; Allergy and Immunology; Chorionic Gonadotropin; Decidua; Endometritis; Environment; Estriol; Estrogens; Female; Fibrin; Genetics; Hematoma; Humans; Maternal-Fetal Exchange; Myocardial Infarction; Placenta; Placenta Diseases; Pregnancy; Pregnancy, Prolonged; Staining and Labeling; Thrombosis; Trophoblasts

Topics: Blood Coagulation; Blood Platelets; Cadaverine; Child; Cross Reactions; Dansyl Compounds; Enzyme Activation; Factor XIII; Factor XIII Deficiency; Female; Fibrin; Glutamine; Hematoma; Hemorrhage; Heterozygote; Humans; Immunodiffusion; Immunoelectrophoresis; Male; Polymorphism, Genetic; Pregnancy; Transferases; Umbilical Cord

Topics: Adult; Cerebral Hemorrhage; Contraceptives, Oral; Dura Mater; Ethinyl Estradiol; Female; Fibrin; Hematoma; Humans; Intracranial Embolism and Thrombosis; Lynestrenol; Mestranol; Middle Aged; Pia Mater; Sinus Thrombosis, Intracranial; Testosterone; Thrombophlebitis

Topics: Animals; Brain; Cerebral Hemorrhage; Craniotomy; Dogs; Fibrin; Fibrinolysis; Hematoma; Injections; Methods; Punctures; Time Factors

Topics: Birth Weight; Blood Vessels; Female; Fibrin; Gestational Age; Glycosaminoglycans; Hematoma; Humans; Myofibrils; Placenta; Placenta Diseases; Pregnancy; Pregnancy Complications; Rupture, Spontaneous; Thromboembolism; Thrombosis; Umbilical Arteries

Topics: Blood; Blood Coagulation Tests; Blood Platelets; Disseminated Intravascular Coagulation; Female; Fibrin; Fibrinogen; Hematoma; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Infant, Newborn, Diseases; Kaolin; Male; Phosphatidylethanolamines; Plasminogen; Skull; Thrombin

Topics: Abortion, Septic; Blood Coagulation Disorders; Disseminated Intravascular Coagulation; Ethanol; Female; Fibrin; Hematoma; Humans; Leukemia; Liver Cirrhosis; Methods; Neoplasms; Phlebitis; Postpartum Hemorrhage; Pregnancy; Pregnancy Complications, Hematologic; Sepsis

Topics: Embryonic and Fetal Development; Female; Fibrin; Hematoma; Humans; Infarction; Maternal Mortality; Maternal-Fetal Exchange; Methods; Placenta; Placenta Diseases; Pregnancy; Radiography; Regional Blood Flow; Thrombosis

Topics: Blood Coagulation Disorders; Blood Coagulation Tests; Cerebral Hemorrhage; Child; Diagnosis; Enzymes; Factor XIII; Fibrin; Genetics, Medical; Hemarthrosis; Hematoma; Hematoma, Subdural; Hemorrhagic Disorders; Humans; Knee Joint

Topics: Animals; Blood Coagulation; Dogs; Drainage; Fibrin; Fracture Healing; Fractures, Bone; Hematoma; Inflammation; Osteotomy; Pathology; Physiology; Research; Suction; Ulna; Wound Healing

Topics: Central Nervous System Diseases; Cerebral Hemorrhage; Child; Encephalitis; Fibrin; Hematoma; Hematoma, Subdural; Humans; Hydrocephalus; Intracranial Embolism; Intracranial Embolism and Thrombosis; Meningitis; Pathology

Topics: Adolescent; Adult; Animals; Anticoagulants; Blood Coagulation Disorders; Bone Development; Child; Child, Preschool; Female; Fibrin; Fractures, Bone; Fractures, Ununited; Hematoma; Hemophilia A; Heparin; Humans; Infant; Male; Periosteum; Pseudarthrosis; Rabbits; Radiography; Radius Fractures; Warfarin; Wound Healing

Topics: Fibrin; Fibrinolysis; Hematoma; Humans; Osteolysis, Essential; Splenomegaly