fibrin and Hematologic-Diseases

Topics: Antigens, CD; Biomarkers; Blood Cell Count; Blood Coagulation Tests; Chromosome Aberrations; Disseminated Intravascular Coagulation; Fibrin; Hematologic Diseases; Humans; Leukemia; Solubility

The Plasma level of soluble fibrin monomer (sFM) was measured in 218 patients with a hematopoietic malignancy. Of them, 198 were diagnosed with disseminates intravascular coagulation (DIC), 20 with Pre-DIC, and 20 with Non-DIC. Pre-DIC was retrospectively defined as the condition at least 1 week before the onset of DIC. The plasma levels of sFM, thrombin-anti-thrombin III complex (TAT), plasmin alpha 2-antiplasmin inhibitor complex (PIC), and FDP-D-dimer were significantly higher in patients with DIC than in those with Non-DIC. These levels were significantly higher in patients with Pre-DIC than in those with Non-DIC. Among these hemostatic parameters, the plasma sFM showed the highest sensitivity and specificity for DIC or Pre-DIC. These findings suggests that sFM is the most valuable marker hemostatic for the diagnosis of DIC and Pre-DIC.

Topics: Biomarkers; Disseminated Intravascular Coagulation; Fibrin; Hematologic Diseases; Humans; Retrospective Studies

Platelets and fibrin play an important role in the coagulation process where they are involved in the maintenance of haemostasis. Many diseases like cancer, thrombotic disease, bleeding disorders, asthma and even conditions like HIV/AIDS are associated with ultrastructural changes in platelets and fibrin, and because of this altered morphology in many diseases, the question now arises whether ultrastructural and morphological analyses of platelets and fibrin networks have a place in contemporary medical research. The present work aims to demonstrate the usefulness of ultrastructural analyses in the broadening of knowledge of disease patterns and suggests that information gained by studying ultrastructure may enhance treatment regimes. We propose an altered haemostasis with changed coagulation factors resulting in a thrombotic event is present in the human body long before the actual event. Thus, by studying the coagulum and platelet profile, preventative actions can be taken. It is therefore concluded that morphology and ultrastructure do indeed have a place in medical research based on the fact that the knowledge obtained through these studies helps in the broadening of knowledge of disease patterns.

Topics: Blood Platelets; Fibrin; Hematologic Diseases; Hemostasis; Humans; Predictive Value of Tests

Inflammatory conditions of the ear, otitis media, are one of the most common disease entities in children. In this study, the role of the plasminogen (plg)/plasmin system for the spontaneous development of chronic otitis media was investigated by the analysis of plg-deficient mice. Whereas essentially all of the wild-type control mice kept a healthy status of the middle ear, all the plg-deficient mice gradually developed chronic otitis media with various degrees of inflammatory changes during an 18-week observation period. Five bacterial strains were identified in materials obtained from the middle ear cavities of six plg-deficient mice. Morphological studies revealed the formation of an amorphous mass tissue and inflammatory changes in the middle ears of plg-deficient mice. Immunohistochemical studies further indicate a mass infiltration of neutrophils and macrophages as well as the presence of T and B cells in the middle ear mucosa of these mice. Extensive fibrin deposition and an abnormal keratin formation were also observed in the tympanic membrane, the middle ear cavity and external ear canal in these mice. These results suggest that plg plays an essential role in protecting against the spontaneous development of chronic otitis media. Our findings also suggest the possibility of using plg for clinical therapy of certain types of otitis media.

Topics: Animals; B-Lymphocytes; Bacteria; Disease Models, Animal; Ear, External; Ear, Middle; Fibrin; Hematologic Diseases; Immunohistochemistry; Keratins; Macrophages; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mucous Membrane; Neutrophil Infiltration; Otitis Media; Plasminogen; T-Lymphocytes; Tympanic Membrane

Topics: Adolescent; Adult; Female; Fibrin; Fibrinolysis; Hematologic Diseases; Humans; Male; Middle Aged; Serum Globulins; Solubility; Time

Topics: Animals; Blood Coagulation Tests; Ethanol; Evaluation Studies as Topic; Female; Fibrin; Fibrinogen; Hematologic Diseases; Humans; Kidney Diseases; Liver Diseases; Male; Neoplasms; Peptide Hydrolases; Postoperative Complications; Postpartum Period; Pregnancy; Protamines; Snakes; Thrombin; Venoms

Topics: Adolescent; Adult; Angina Pectoris; Chronic Disease; Diabetes Mellitus; Female; Fibrin; Fibrinogen; Hematologic Diseases; Humans; Kidney Diseases; Liver Diseases; Male; Middle Aged; Myocardial Infarction; Neoplasms

Topics: Adult; Blood Coagulation Tests; Blood Urea Nitrogen; Child; Disseminated Intravascular Coagulation; Female; Fibrin; Glomerulonephritis; Hematologic Diseases; Humans; Kidney Diseases; Lupus Erythematosus, Systemic; Male; Nephritis; Nephrotic Syndrome; Urinary Tract Infections; Vascular Diseases

Topics: Abruptio Placentae; Adult; Animals; Anuria; Bilirubin; Blood Coagulation Disorders; Dogs; Erythrocytes; Female; Fibrin; Fibrinolysis; Hematologic Diseases; Hemolysis; Humans; Mice; Pregnancy; Rabbits; Rats; Shock, Hemorrhagic; Thrombin; Thromboplastin

Topics: Aminocaproates; Aprotinin; Cellulose; Chromatography; Chromatography, Gel; Fibrin; Fibrinogen; Hematologic Diseases; Humans; Immunoelectrophoresis; Liver Diseases; Macroglobulins; Neoplasms; Plasminogen; Streptokinase; Thrombin; Thrombosis

Topics: Child; Erythroblastosis, Fetal; Factor XIII; Fibrin; Hematologic Diseases; Hemorrhagic Disorders; Humans; Infant; Infant, Newborn; Infant, Premature

Topics: Fibrin; Fibrinolysis; Hematologic Diseases; Humans; Neoplasms

Topics: Coagulants; Fibrin; Fibrinogen; Fibrinolysis; Hematologic Diseases; Hemostatics; Humans

Topics: Antifibrinolytic Agents; Body Fluids; Enzyme Precursors; Female; Fibrin; Fibrinogen; Fibrinolysin; Hematologic Diseases; Humans; Neoplasms; Plasminogen; Pregnancy; Thrombolytic Therapy; Urine

Topics: Erythroblastosis, Fetal; Fetus; Fibrin; Fibrinogen; Hematologic Diseases; Hemorrhage; Humans; Infant, Newborn; Prothrombin

Topics: Fibrin; Heart; Heart Diseases; Hematologic Diseases; Heparin; Humans; In Vitro Techniques; Thrombosis