fibrin and Hemarthrosis

fibrin has been researched along with Hemarthrosis* in 3 studies

Other Studies

3 other study(ies) available for fibrin and Hemarthrosis

ArticleYear
The potential role of protease systems in hemophilic arthropathy.
    Blood advances, 2022, 09-27, Volume: 6, Issue:18

    Hemophilic arthropathy (HA) is characterized by joint damage following recurrent joint bleeds frequently observed in patients affected by the clotting disorder hemophilia. Joint bleeds or hemarthroses trigger inflammation in the synovial tissue, which promotes damage to the articular cartilage. The plasminogen activation system is integral to fibrinolysis, and the urokinase plasminogen activator, or uPA in particular, is strongly upregulated following hemarthroses. uPA is a serine protease that catalyzes the production of plasmin, a broad-spectrum protease that can degrade fibrin as well as proteins of the joint extracellular matrix and cartilage. Both uPA and plasmin are able to proteolytically generate active forms of matrix metalloproteinases (MMPs). The MMPs are a family of >20 proteases that are secreted as inactive proenzymes and are activated extracellularly. MMPs are involved in the degradation of all types of collagen and proteoglycans that constitute the extracellular matrix, which provides structural support to articular cartilage. The MMPs have an established role in joint destruction following rheumatoid arthritis (RA). They degrade cartilage and bone, indirectly promoting angiogenesis. MMPs are also implicated in the pathology of osteoarthritis (OA), characterized by degradation of the cartilage matrix that precipitates joint damage and deformity. HA shares a number of overlapping pathological characteristics with RA and OA. Here we discuss how the plasminogen activation system and MMPs might exacerbate joint damage in HA, lending insight into novel possible therapeutic targets to reduce the comorbidity of hemophilia.

    Topics: Arthritis, Rheumatoid; Collagen; Enzyme Precursors; Fibrin; Fibrinolysin; Hemarthrosis; Hemophilia A; Humans; Matrix Metalloproteinases; Osteoarthritis; Peptide Hydrolases; Plasminogen; Proteoglycans; Urokinase-Type Plasminogen Activator

2022
Elimination of fibrinogen from synovial joints.
    Annals of the rheumatic diseases, 1973, Volume: 32, Issue:1

    Topics: Absorption; Animals; Citrates; Disease Models, Animal; Female; Fibrin; Fibrinogen; Hemarthrosis; Heparin; Hindlimb; Humans; Injections, Intra-Articular; Iodine Isotopes; Plasma; Rabbits; Synovial Membrane; Time Factors

1973
CONGENITAL DEFICIENCY OF FIBRIN-STABILIZING FACTOR. OBSERVATION OF A NEW CASE.
    The New England journal of medicine, 1965, May-06, Volume: 272

    Topics: Blood Coagulation Disorders; Blood Coagulation Tests; Cerebral Hemorrhage; Child; Diagnosis; Enzymes; Factor XIII; Fibrin; Genetics, Medical; Hemarthrosis; Hematoma; Hematoma, Subdural; Hemorrhagic Disorders; Humans; Knee Joint

1965