fibrin and Granuloma

In contrast to fungal dermatitis, fungal glossitis and disseminated visceral mycosis, fungal infection of the lung has so far rarely been described in reptiles. Pulmonary fungal granulomas were diagnosed histopathologically within the scope of post mortem examinations. Fragments of the 18S-internal transcribed spacer1-5.8S rDNA (SSU-ITS1-5.8S) and 28S rDNA (LSU), including domains (D)1 and D2 as well as the protein coding gene translation elongation factor 1 alpha (TEF) were used for phylogenetical analysis after isolation of the fungal pathogen by culturing. Ten reptiles, including lizards (n = 6), snakes (n = 1), crocodilians (n = 2) and tortoises (n = 1) presented with pulmonary fungal granulomas (n = 8) and fibrinous pneumonia (n = 2) caused by different non-clavicipitaceous and clavicipitaceous species of the order Hypocreales. Purpureocillium lavendulum (n = 2) and Metarhizium robertsii (n = 1) as the etiologic agents of pneumonia in reptile species are described for the first time. Fungal pulmonary granulomas caused by clavicipitaceous fungi (n = 6) were all associated with disseminated visceral mycosis as well as oral fungal granulomas (n = 4) and/or fungal dermatitis (n = 1). Differing infection routes being likely for clavicipitaceous and non-clavicipitaceous fungal pathogens. A potential zoonotic health risk should be taken into account during necropsy or lung sampling in live reptiles with pulmonary fungal granulomas, since human infections, mainly keratitis and sclerokeratitis, caused by Beauveria bassiana, Metarhizium robertsii and Purpureocillium lilacinum, have occasionally been described.

Topics: Alligators and Crocodiles; Animals; Beauveria; Boidae; DNA, Ribosomal; Fibrin; Granuloma; Humans; Hypocreales; Lizards; Lung; Metarhizium; Mycoses; Phylogeny; Pneumonia; Reptiles; Zoonoses

Topics: Adult; Antiviral Agents; Bone Marrow; Cytomegalovirus; Cytomegalovirus Infections; Fibrin; Glomerulonephritis; Granuloma; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Viral Load

Treatment of chronic inflammatory diseases with tumor necrosis factor alpha (TNF-α) antagonists has been associated with increased risk of tuberculosis (TB). We examined the usefulness of the rabbit model of active pulmonary TB for studying the impact of the human immune modulatory reagent etanercept on the host immune response. Control of Mycobacterium tuberculosis (Mtb) infection, disease pathology, and the global transcriptional response in Mtb-infected lungs of rabbits were studied. Etanercept treatment exacerbated disease pathology and reduced bacillary control in the lungs, compared with infected untreated animals. Reduced collagen and fibrin deposition in the granulomas was associated with significant downregulation of the collagen metabolism and fibrosis network genes and upregulation of genes in the inflammatory response and cell recruitment networks in the lungs of etanercept treated, compared with untreated rabbits. Our results suggest that targeting the TNF-α signaling pathway disrupts the tissue remodeling process, which is required for the formation and maintenance of well-differentiated granulomas and for control of Mtb growth in the lungs. These results validate the use of the rabbit model for investigating the impact of selected human immune modulatory drugs, such as a TNF-α antagonist, on the host immune response and pathogenesis in TB.

Topics: Animals; Collagen; Disease Models, Animal; Down-Regulation; Etanercept; Fibrin; Granuloma; Inflammation; Lung; Mycobacterium tuberculosis; Rabbits; Tuberculosis, Pulmonary; Tumor Necrosis Factor-alpha; Up-Regulation

Topics: Adult; Bone Marrow Diseases; Epstein-Barr Virus Infections; Female; Fibrin; Granuloma; Humans

We previously reported 24 cases of marrow fibrin-ring granuloma (FRG) encountered in 1 institution and concluded that, contrary to previous studies showing marrow FRG as a diagnostic marker for Q fever, Epstein-Barr virus (EBV) was the most common proven cause of such FRG. The present study characterized patients with EBV-associated marrow FRG. We retrospectively reviewed 17 cases of EBV-associated FRG (43% of 40 cases with marrow FRG) diagnosed by bone marrow biopsy. Patients with EBV-associated hemophagocytic lymphohistiocytosis (5/17 patients) and chronic active EBV infection (4/17) constituted 53% of patients with EBV-associated FRG. Three patients had lymphoma without marrow involvement. All patients except 1 presented first with fever; splenomegaly was the next most common clinical finding (12/17). Cytopenia was observed in the 17 cases: anemia in 16, thrombocytopenia in 9, and leukopenia in 8. Patients with EBV-associated FRG showed lower survival outcomes than did patients without EBV (median, 3.0 vs 11.8 months; P = .009). Patients with bone marrow FRG accompanied by fever require careful evaluation to discern whether active EBV infection is involved because the prognosis is poor.

Topics: Adult; Aged; Bone Marrow Diseases; Child; Child, Preschool; Epstein-Barr Virus Infections; Female; Fibrin; Granuloma; Humans; Lymphohistiocytosis, Hemophagocytic; Male; Middle Aged; Prognosis

Drug-eluting stents effectively reduce restenosis but may increase late thrombosis and delayed restenosis. Persistent polymer, the drug, or a combination of both could be responsible. Local delivery of Biolimus A9, a rapamycin derivative, from a polymer-free BioFreedom stent (Biosensors International) may prevent these complications.. We compared high-dose (HD) (225 microg/14 mm Biolimus A9) and low-dose (LD) (112 microg/14 mm Biolimus A9) BioFreedom stents with a polymer-coated sirolimus-eluting Cypher stent (SES) and a bare-metal stent (BMS) at 28 days and 180 days in an overstretch coronary mini-swine model with histomorphometric and histological analysis. At 28 days, there was a reduction in neointimal proliferation by HD, LD, and SES compared with BMS (neointimal thickness: HD, 0.080+/-0.032; LD, 0.085+/-0.038; SES, 0.064+/-0.037; BMS, 0.19+/-0.111 mm; P<0.001; BMS > HD/LD/SES). At 180 days, both BioFreedom stents were associated with reduced neointimal proliferation, whereas SES exhibited increased neointima (neointimal thickness: HD, 0.12+/-0.034; LD, 0.10+/-0.040; SES, 0.20+/-0.111; BMS, 0.17+/-0.099 mm; P<0.001; SES > HD/LD; BMS > LD). At 180 days, BioFreedom stents showed decreased fibrin and inflammation, including granuloma and giant cells, compared with SES.. The polymer-free Biolimus A9-coated stent demonstrates equivalent early and superior late reduction of intimal proliferation compared with SES in a porcine model. After implantation of BioFreedom stent, delayed arterial healing was minimal, and there was no increased inflammation at 180 days compared with SES implantation. The use of polymer-free stents may have a potential long-term benefit over traditional polymeric-coated drug-eluting stents.

Topics: Animals; Cell Proliferation; Coronary Restenosis; Drug-Eluting Stents; Fibrin; Giant Cells; Granuloma; Inflammation; Sirolimus; Swine; Swine, Miniature; Tunica Intima; Wound Healing

We describe a 66-year-old woman hospitalized with fever, fatigue and hepatopathy. In her medical history arterial hypertension (treated with propranolol and lisinopril), diabetes mellitus type 2 (no treatment before admission) and a gout arthropathy were noted wherefore a therapy with allopurinol 300 mg per day has been started 4 months before. Liver biopsy revealed fibrin-ring granulomas, compatible with allopurinol-induced hepatitis. Because of persistence of high fever after stopping allopurinol, steroids (1 mg/kg) were started. Under this treatment, she developed pancytopenia and fever. The bone marrow aspiration revealed Leishmania infantum. A second liver biopsy showed amastigotes and a disappearance of the granulomas. The history revealed a travel to Malta 2 years earlier. Despite adequate treatment with liposomal amphotericin B the patient deteriorated and finally died in septic shock.

Topics: Aged; Allopurinol; Animals; Biopsy; Bone Marrow; Chemical and Drug Induced Liver Injury; Fatal Outcome; Female; Fibrin; Gout Suppressants; Granuloma; Humans; Leishmania infantum; Leishmaniasis, Visceral; Liver

Fibrin ring granulomas are rare lesions whose pathophysiology has remained somewhat elusive. It has been suggested that these peculiar lesions are related to focal vasculitis with endothelial injury and deposition of immune complexes. Fibrin ring granulomas have been described in Q fever; in viral infections such as cytomegalovirus, Epstein-Barr virus, and hepatitis A virus; and in other conditions. We submit the first reported case of fibrin ring granuloma in a patient with chronic hepatitis C infection, in whom other potential etiologies have been excluded, and offer a brief review of available literature on the pathogenesis of both conditions.

Topics: Fibrin; Granuloma; Hepatitis C, Chronic; Humans; Immune Complex Diseases; Male; Middle Aged; Vasculitis

Fibrin-ring granuloma (FRG), which can be found in bone marrow or the liver, is a subtype of epithelioid granuloma characterized by a central fat vacuole and annular peripheral fibrinoid materials. FRG has been proven to be associated with many etiologies such as several infectious organisms (Coxiella burnett; Epstein-Barr Virus, EBV; cytomegalovirus, CMV; and hepatitis A virus), allopurinol induced hepatitis, Hodgkin's lymphoma, and peripheral T-cell lymphoma.. We retrospectively reviewed 24 patients diagnosed with FRG by bone marrow biopsy at a single institute between 1995 and 2004. We reviewed clinical symptoms and laboratory findings of the patients, classified them by etiology, and compared prognosis of each group.. The most common cause of FRG was acute or chronic EBV infection. Chronic or acute EBV infection was associated with 41.4% of patients (10/24). Of the remaining patients, 33.3% (8/24) were leukemia or lymphoma patients after chemotherapy, 4.2% (1/24) was a patient with hepatic failure, and 20.8% (5/24) were diagnosed as fever of unknown origin. The most common symptom and clinical finding were fever and cytopenia. EBV-associated group comprised chronic active EBV infection, EBV-associated hemophagocytic histiocytosis, acute EBV infection, EBV-associated lymphoproliferative disease, and Langerhans' cell histiocytosis. The EBV-associated group showed a lower survival probability compared with the non-EBV group (P<0.05).. Patients with bone marrow fibrin ring granuloma accompanied by fever require an active workup to find out the cause of infectious agents including EBV infection particularly due to their poor prognosis.

Topics: Adolescent; Adult; Aged; Bone Marrow Diseases; Child; Child, Preschool; Epstein-Barr Virus Infections; Female; Fibrin; Granuloma; Herpesvirus 4, Human; Humans; In Situ Hybridization; Male; Middle Aged; Polymerase Chain Reaction; Prognosis; Q Fever; Retrospective Studies; Survival Rate

Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Antibodies, Heterophile; Bone Marrow Diseases; CD4-CD8 Ratio; Female; Fibrin; Granuloma; Humans

Topics: Diagnosis, Differential; Fibrin; Granuloma; Hepatitis; Humans; Male; Middle Aged; Q Fever

Topics: Biopsy, Needle; Bone Marrow; Diagnosis, Differential; Egypt; Fever of Unknown Origin; Fibrin; Granuloma; Hepatitis; Humans; Liver; Liver Function Tests; Male; Middle Aged; Osteomyelitis; Q Fever; Travel

Tissue injury is accompanied by increased vascular permeability and influx of plasma proteins including fibrinogen. Fibrinogen is converted into a fibrin matrix by procoagulants activated at the site of tissue injury and inflammation. This fibrin matrix is thought to participate early in the inflammatory response by providing a temporary protein "scaffold" for inflammatory cell adhesion and migration, and subsequent remodeling of the tissue with permanent extracellular matrix proteins such as collagen. Collagen and fibronectin have been shown to regulate the expression of inflammatory cytokines, but whether fibrin can regulate cytokine expression is not known. We hypothesized that fibrin induces the expression of the proinflammatory cytokine IL-1 beta and sought to explore mechanisms responsible for this induction. In this report, we demonstrate that fibrin stimulates human PBMCs to express IL-1 beta message and protein. We show that induction of IL-1 beta by fibrin is mediated partly by the integrin receptor CD11b/CD18 and modulated by cytoskeletal rearrangement. Fibrin also suppresses production of IL-1 receptor antagonist (IL-1ra) a non-bioactive competitor of IL-1 for IL-1Rs. We propose that injured tissues where the conditions favor coagulation and fibrin accumulation, the interaction between mononuclear cells and the newly formed fibrin matrices may elicit the production of the proinflammatory cytokine IL-1 beta. This proposal is supported by immunohistochemical studies which show the co-distribution of fibrin and IL-1 beta in granulomas in lung sections from patients with the systemic granulomatous disease, sarcoidosis.

Topics: Capillary Permeability; CD18 Antigens; Cytoskeleton; Fibrin; Fibrinogen; Gene Expression Regulation; Granuloma; Humans; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Lung; Monocytes; Sarcoidosis, Pulmonary; Sialoglycoproteins

Fibrin ring granulomas of the bone marrow are described in two organ transplant patients (one renal, one cardiac) with disseminated cytomegalovirus infection. Infection was documented by viral cultures and seroconversion, and in both cases typical cytomegalic cells were identified in proximity to the fibrin ring granulomas. These represent the first case reports of bone marrow fibrin ring granulomas associated with cytomegalovirus.

Topics: Bone Marrow Diseases; Cytomegalovirus Infections; Fibrin; Granuloma; Humans; Male; Middle Aged

Hepatic fibrin-ring granulomas were found in a 70-year-old man with prolonged fever and inflammatory syndrome. Diagnosis of giant cell arteritis was confirmed by temporal artery biopsy. Other diseases usually associated with fibrin-ring granulomas in liver, such as Q fever, cytomegalovirus hepatitis, infectious mononucleosis, Hodgkin's disease, non-Hodgkin's lymphoma, allopurinol treatment, and visceral leishmaniasis, were ruled out. This report suggests that giant cell arteritis should be considered as an additional cause of hepatic fibrin-ring granulomas.

Topics: Aged; Fibrin; Giant Cell Arteritis; Granuloma; Humans; Liver; Liver Diseases; Male

Fibrin ring granuloma is characterized by a fibrinous ring surrounding a central fat vacuole. It has been found in the liver and bone marrow of patients with Q fever, and occasionally with visceral leishmaniasis, cytomegalovirus, Epstein-Barr virus, Staphylococcus epidermidis infections, Hodgkin's lymphoma, and hypersensitivity to allopurinol. We describe a case of serologically confirmed viral hepatitis A with this lesion in the liver biopsy. A false positive anti-hepatitis A virus IgM result has been excluded. This is, to our knowledge, the second reported case of type A hepatitis with hepatic fibrin ring granulomas. It confirms that hepatitis A should be included in the differential diagnosis of this lesion.

Topics: Acute Disease; Female; Fibrin; Granuloma; Hepatitis A; Humans; Liver; Liver Diseases; Middle Aged; Q Fever

Topics: Female; Fibrin; Granuloma; Humans; Liver; Liver Neoplasms; Lupus Erythematosus, Systemic; Middle Aged

Hepatic fibrin-ring granulomas were found in a 30-year-old patient with serologically confirmed hepatitis A. Other causes associated with the presence of fibrin-ring granulomas in the liver, such as Hodgkin's and non-Hodgkin's lymphoma, cytomegalovirus infection, visceral leishmaniasis, and consumption of allopurinol, were ruled out. It is suggested that hepatitis A must be included in the differential diagnosis of a patient with hepatic fibrin-ring granulomas.

Topics: Adult; Fibrin; Granuloma; Hepatitis A; Humans; Liver Diseases; Male

To test the hypothesis that allopurinol-associated granulomatous hepatitis may present itself with fibrin-ring granulomas, we requested details of such cases, as reported to the World Health Organization, from 13 national adverse reaction monitoring centers, and as reported in the literature. Details and histology of 6 cases were obtained and reviewed. All consisted of acute hypersensitivity signs with fever, rash, arthralgia, or eosinophilia as hallmarks, starting within 6 wk of commencing treatment with allopurinol. In all cases there were either epithelioid granulomas or granulomalike lesions, but none of these contained fibrin rings. It is concluded that, if fibrin-ring granulomas are a manifestation of allopurinol-induced granulomatous hepatitis, this feature is probably uncommon.

Topics: Adult; Aged; Allopurinol; Chemical and Drug Induced Liver Injury; Female; Fibrin; Granuloma; Humans; Male

Hepatic fibrin-ring granulomas and leishmania parasites were found in the liver biopsy specimens of 3 patients with prolonged fever and hepatosplenomegaly. It was recognition of the leishmanias in the liver biopsy specimen that prompted the diagnosis in all cases. There was no evidence of Q fever, Hodgkin's disease, cytomegalovirus hepatitis, or allopurinol treatment, which are the recognized causes of hepatic fibrin-ring granulomas. This report extends the range of etiologies of hepatic fibrin-ring granulomas. As a result, leishmaniasis should always be a consideration to the pathologist and the clinician in the differential diagnosis of fibrin-ring granulomas.

Topics: Aged; Biopsy; Diagnosis, Differential; Female; Fibrin; Granuloma; Humans; Infant; Leishmaniasis, Visceral; Liver; Liver Diseases, Parasitic; Male; Middle Aged; Q Fever

Topics: Adult; Female; Fibrin; Granuloma; Humans; Liver Diseases; Staphylococcal Infections; Staphylococcus epidermidis

The dermal changes in four cases of generalized granuloma annulare (GGA) and in four of localized granuloma annulare (LGA) were studied ultrastructurally, and the findings in the two groups were compared. The basic alterations were similar in both types, and showed varied stages of development. The cellular infiltrate was composed mostly of histiocytes. Cell debris was found in all lesions. The degenerative changes affected the collagen fibers, the elastic fibers, and the cellular infiltrate. Of special interest are the following findings in GGA: First, masses of intercellular fibrin material were seen only in the lesions of GGA. Second, thick and multilayered basal lamina around capillaries was apparently more common in the generalized form. These changes may suggest that a more pronounced immune reaction is responsible for the development of the generalized form of the disease.

Topics: Adult; Aged; Blood Vessels; Connective Tissue; Female; Fibrin; Granuloma; Histiocytes; Humans; Male; Middle Aged; Skin; Skin Diseases

Hepatic fibrin-ring granulomas were found in a 35-yr-old man who developed fever, myalgias, rash, eosinophilia, and abnormal liver function tests 4 wk after the beginning of allopurinol treatment. All clinical and biochemical abnormalities spontaneously resolved within 6 wk after cessation of therapy. There was no evidence for Q fever or Hodgkin's disease, which are the recognized causes of hepatic fibrin-ring granulomas. It is suggested that allopurinol hypersensitivity might be an additional cause of these peculiar granulomas.

Topics: Adult; Allopurinol; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Fibrin; Granuloma; Humans; Liver; Liver Diseases; Male

Comparative immunofluorescence study with murine lepromas induced in C57BL/6NJcl (immunologically high responder) and CBA/N (low responder) mouse strains revealed that fibrin formation was associated with cell-mediated immune resistance against invasive bacilli. Histochemistry on paraffin sections further elucidated fibroblast proliferation and formation of collagen fibers following fibrin deposition only in murine lepromas with positive host reactions.

Topics: Animals; Collagen; Fibrin; Fluorescent Antibody Technique; Granuloma; Immunity, Cellular; Mice; Mice, Inbred Strains; Mycobacterium Infections; Mycobacterium lepraemurium; Species Specificity

Experimental infection in mice with Dermatophilus (D.) congolensis-like microorganisms was carried out, intraperitoneally and subcutaneously. This strain had been isolated from porcine tonsil and reported to be different in some morphological and biological points from D. congolensis. Macroscopic examination revealed multiple abscesses in the peritoneal cavities, or subcutaneous abscesses after the intraperitoneal or subcutaneous injection respectively. Histopathologic examination revealed the characteristic arrangement of the neutrophils surrounding the bacterial colony and peripheral macrophages in the abscess lesions. The lesions contained many microorganisms which showed wide range of the characteristic morphologic variation such as: mycelial elements, coccoid elements and large coccoid elements with transverse or longitudinal septa. Chlamydospore-like elements were sometimes found in the microcolonies in early lesions. The morphology of the lesions and the microorganisms was compared with those of other bacteria including D. congolensis.

Topics: Abscess; Actinomycetales; Actinomycetales Infections; Animals; Fibrin; Granuloma; Inflammation; Liver Abscess; Macrophages; Mice; Necrosis; Neutrophils; Palatine Tonsil; Pancreatic Diseases; Peritoneal Cavity; Splenic Diseases; Swine

Eighteen cases of granuloma annulare were classified histopathologically and examined by direct immunofluorescence. The three different histopathologic types of granuloma annulare were compared with the result of immunofluorescence examination. No features of leukocytoclastic vasculitis were seen. Direct immunofluorescence of granuloma annulare does not reveal any consistent diagnostic pattern. Dermal desposition of fibrin in necrobiotic areas were noted in 8 cases of 18. Blood vessel and/or basement membrane deposition of IgM and C3 was inconsistent and does not support an immune complex vasculitis. Direct immunofluorescence is useful in studying the pathogenesis of granuloma annulare. The finding of fibrin, together with the histology, suggests to us a delayed hypersensitivity reaction as the dominant pathogenic event.

Topics: Complement C3; Fibrin; Fluorescent Antibody Technique; Granuloma; Humans; Immunoglobulin M; Skin Diseases

Liver lesions in 17 patients with serologically diagnosed Q fever are described. A distinctive granulomatous pattern, with granuloma formation plus a fibrinoid ring, was observed in 14 cases. In two cases the fibrinoid material consisted of fibrillar eosinophilic structures without an annular arrangement, interspersed among epithelioid cells. In only one case was a nonspecific granuloma (devoid of fibrinoid material) noted. We conclude that the association of a granuloma with fibrinoid material is highly indicative of Q fever, but serial sections are often necessary to demonstrate this pattern.

Topics: Adult; Aged; Biopsy, Needle; Diagnosis, Differential; Fibrin; Granuloma; Hepatitis; Humans; Liver; Male; Middle Aged; Q Fever

Topics: Animals; Chronic Disease; Fibrin; Fibrinolysin; Fibrinolysis; Granuloma; Male; Mice; Mice, Inbred BALB C; Plasminogen Activators; Plasminogen Inactivators; Schistosomiasis; Spectrometry, Fluorescence; Time Factors; Urokinase-Type Plasminogen Activator

In 6 cases of granuloma anulare direct immunofluorescence studies were carried out with anti-fibrinogen and anti-immunoglobulin sera. Fibrin deposition was found in all lesions. The result is discussed with reference to local fibrinolysis.

Topics: Adolescent; Adult; Child; Female; Fibrin; Fibrinolysis; Fluorescent Antibody Technique; Granuloma; Humans; Male; Middle Aged

The study includes 40 cases of skin replacement performed by an ophthalmologist over a period of 4 years. An absorbable implant material, Bioplast fibrin, was used as a graft following the extirpation of 12 eyelid tumors, the treatment of eight fresh, destructive skin injuries, and the removal of deforming scars around the eyes, in 20 cases. The biocompatible implant provided barrier properties preventing infection or excessive fluid loss. The resorption rate was adjusted to 3-4 weeks. These grafts were gradually replaced by new epithelial tissue growing in from the periphery of the wound edge. The new tissue had the elasticity and cosmetic appearance of surrounding skin. Thus, small periorbital skin tumors can now be removed without the necessity of doing a split thickness skin graft to cover the defect.

Topics: Adolescent; Adult; Aged; Biocompatible Materials; Cicatrix; Dermatologic Surgical Procedures; Eye Injuries; Eyelid Neoplasms; Female; Fibrin; Granuloma; Humans; Male; Middle Aged; Skin; Skin Diseases

Direct immunofluorescence studies were carried out in eleven specimens of granuloma annulare. The results (in all cases) indicate the presence of focal deposition of fibrin, localized primarily in the intervascular portion of the dermis, corresponding to the granulomatous and necrobiotic areas. These findings implicate the cellular mechanism of delayed hypersensitivity with focal involvement of the clotting system in the development of granuloma annulare lesion.

Topics: Blood Coagulation; Complement C3; Fibrin; Fluorescent Antibody Technique; Granuloma; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Immunoglobulin M; Necrobiosis Lipoidica; Sarcoidosis; Skin; Skin Diseases

Topics: Absorption; Animals; Anti-Infective Agents, Local; Barium Sulfate; Cats; Diatrizoate; Disease Models, Animal; Drug Evaluation; Esophageal Perforation; Exudates and Transudates; Fibrin; Granuloma; Histiocytes; Intestines; Lymphocytes; Mediastinitis; Mouth; Plasma Cells; Radiography

Topics: Adult; Eosinophils; Erythrocytes; Fibrin; Foreign-Body Reaction; Gloves, Surgical; Granulation Tissue; Granuloma; Hemosiderin; Humans; Iatrogenic Disease; Leukocytes; Male; Postoperative Complications; Scrotum; Splenectomy; Starch; Testicular Hydrocele; Tissue Adhesions

Topics: Arthritis, Rheumatoid; Autopsy; Collagen Diseases; Dermatomyositis; Diagnosis, Differential; Fibrin; Granuloma; Histocytochemistry; Humans; Lung; Lupus Erythematosus, Systemic; Polyarteritis Nodosa; Pulmonary Alveoli; Pulmonary Fibrosis; Rheumatic Fever; Scleroderma, Systemic

Topics: Adenoma; Carcinoma; Culture Media; Culture Techniques; Cyclohexanecarboxylic Acids; Fibrin; Fibrinogen; Fibrinolysis; Fibroma; Granuloma; Granuloma, Giant Cell; Hemangioma; Humans; Methylamines; Mouth Neoplasms; Neoplasms, Muscle Tissue

Topics: Biopsy; Blood Vessels; Complement System Proteins; Fibrin; Granuloma; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulins; Lymph Nodes; Sarcoidosis; Skin Tests