fibrin and Eye-Injuries

to evaluate the efficacy and the safety of low dose intraocular tissue plasminogen activator (rt-PA) in the treatment of traumatic hyphema and postoperative fibrinous membrane.. Six microg to 10 microg of rt-PA was injected into the anterior chamber to treat severe fibrinous postoperative membranes and total traumatic hyphemae.. Thirteen eyes of 13 patients were treated. Four cases of traumatic hyphema and 9 cases of fibrinous membranes were included. Complete fibrinolysis within 24 hours was observed in 4 cases (30.8%). A partial success was noted in 7 eyes (53.8%). No beneficial effect was observed in two cases of traumatic hyphema associated with intravitreal hemorrhage after penetrating trauma. No side effect attributable to rt-PA occurred.. Low dose intraocular rt-PA appears to be safe and effective in the treatment of postoperative fibrinous membrane and endocular hemorrhage limited to the anterior chamber.

Topics: Adolescent; Adult; Aged; Child; Eye Injuries; Female; Fibrin; Fibrinolytic Agents; Humans; Hyphema; Inflammation; Male; Middle Aged; Ophthalmologic Surgical Procedures; Postoperative Complications; Recombinant Proteins; Tissue Plasminogen Activator

to evaluate the efficacy and the safety of low dose intraocular tissue plasminogen activator (rt-PA) in the treatment of traumatic hyphema and postoperative fibrinous membrane.. Six microg to 10 microg of rt-PA was injected into the anterior chamber to treat severe fibrinous postoperative membranes and total traumatic hyphemae.. Thirteen eyes of 13 patients were treated. Four cases of traumatic hyphema and 9 cases of fibrinous membranes were included. Complete fibrinolysis within 24 hours was observed in 4 cases (30.8%). A partial success was noted in 7 eyes (53.8%). No beneficial effect was observed in two cases of traumatic hyphema associated with intravitreal hemorrhage after penetrating trauma. No side effect attributable to rt-PA occurred.. Low dose intraocular rt-PA appears to be safe and effective in the treatment of postoperative fibrinous membrane and endocular hemorrhage limited to the anterior chamber.

Topics: Adolescent; Adult; Aged; Child; Eye Injuries; Female; Fibrin; Fibrinolytic Agents; Humans; Hyphema; Inflammation; Male; Middle Aged; Ophthalmologic Surgical Procedures; Postoperative Complications; Recombinant Proteins; Tissue Plasminogen Activator

Topics: Eye Injuries; Fibrin; Humans; Military Medicine; Military Personnel; Ophthalmology; Retrospective Studies; Warfare

Subtotal open-sky vitrectomy can be used to improve visual function in some eyes for which closed vitrectomy is useless. Open-sky vitrectomy allows easier access for surgical instruments, especially to anterior fundus structures. The technique also improves the visibility of intraocular structures. The surgical procedure, which uses special instruments and high-molecular-weight hyaluronic acid, is divided into four stages: preparation, operating inside the vitreous cavity, wound closure, and retinal reattachment. In 290 consecutive operations for which complete follow-up data are available, retinal reattachment was achieved in 61 eyes (21%). The greatest number of successes (16 of 30 cases [53%]) was achieved in severe tractional retinal detachments. Such results are encouraging because these eyes were considered inoperable by other techniques. Open-sky vitreous surgery is performed through a corneal incision, but a scleral incision over the pars plana may become the method of choice in selected cases. The development of a preretinal fibrin membrane, as a result of either a closed vitrectomy or an open-sky procedure, may be a major cause of postoperative failure. Hypotony during surgery is probably the main precipitating factor of intraocular fibrin membrane formation.

Topics: Adolescent; Adult; Cataract; Child; Child, Preschool; Eye Diseases; Eye Foreign Bodies; Eye Injuries; Female; Fibrin; Humans; Lens Subluxation; Male; Middle Aged; Retinal Detachment; Scleral Buckling; Vitreous Body

The study includes 40 cases of skin replacement performed by an ophthalmologist over a period of 4 years. An absorbable implant material, Bioplast fibrin, was used as a graft following the extirpation of 12 eyelid tumors, the treatment of eight fresh, destructive skin injuries, and the removal of deforming scars around the eyes, in 20 cases. The biocompatible implant provided barrier properties preventing infection or excessive fluid loss. The resorption rate was adjusted to 3-4 weeks. These grafts were gradually replaced by new epithelial tissue growing in from the periphery of the wound edge. The new tissue had the elasticity and cosmetic appearance of surrounding skin. Thus, small periorbital skin tumors can now be removed without the necessity of doing a split thickness skin graft to cover the defect.

Topics: Adolescent; Adult; Aged; Biocompatible Materials; Cicatrix; Dermatologic Surgical Procedures; Eye Injuries; Eyelid Neoplasms; Female; Fibrin; Granuloma; Humans; Male; Middle Aged; Skin; Skin Diseases

For some time fibrin adhesion is successfully used instead of sutures in different branches of surgery. We tested in animal experiments whether this method can be used for a sutureless closure of perforating corneal and corneoscleral wounds. Our results up to now do not show us any such possibility.

Topics: Animals; Dogs; Eye Injuries; Factor XIII; Fibrin; Fibrinogen; Ophthalmologic Surgical Procedures; Rabbits; Thrombin; Tissue Adhesives

The study includes a series of 38 patients with retinal detachment of different aetiology. Scleral reduction combined with the intrascleral implantation of absorbable Bioplast fibrin scleral buckling rods was performed and reattachment achieved in 31 cases. The implant material is biocompatible and is eliminated from the eye in the course of a few weeks.

Topics: Adolescent; Adult; Aged; Eye Injuries; Fibrin; Humans; Middle Aged; Myopia; Retinal Detachment; Scleral Buckling

Topics: Adhesives; Cornea; Eye Injuries; Fibrin; Humans; In Vitro Techniques; Wound Healing