fibrin has been researched along with Electric-Injuries* in 3 studies
3 other study(ies) available for fibrin and Electric-Injuries
| Article | Year |
|---|---|
Alpha(2)-antiplasmin gene deficiency in mice does not affect neointima formation after vascular injury.
The hypothesis that alpha(2)-antiplasmin (alpha(2)-AP), the main physiological plasmin inhibitor, plays a role in neointima formation was tested with use of a vascular injury model in wild-type (alpha(2)-AP(+/+)) and alpha(2)-AP-deficient (alpha(2)-AP(-/-)) mice. The neointimal and medial areas were similar 1 to 3 weeks after electric injury of the femoral artery in alpha(2)-AP(+/+) and alpha(2)-AP(-/-) mice, resulting in comparable intima/media ratios (eg, 0.43+/-0.12 and 0.42+/-0.11 2 weeks after injury). Nuclear cell counts in cross-sectional areas of the intima of the injured region were also comparable in arteries from alpha(2)-AP(+/+) and alpha(2)-AP(-/-) mice (78+/-19 and 69+/-8). Fibrin deposition was not significantly different in arteries of both genotypes 1 day after injury, and no mural thrombosis was detected 1 week after injury. Fibrinolytic activity in femoral arterial sections, as monitored by fibrin zymography, was higher in alpha(2)-AP(-/-) mice 1 week after injury (P<0.001) but was comparable in both genotypes 2 and 3 weeks after injury. Staining for elastin did not reveal significant degradation of the internal elastica lamina in either genotype. Immunocytochemical analysis revealed a comparable distribution pattern of alpha-actin-positive smooth muscle cells in both genotypes. These findings indicate that the endogenous fibrinolytic system of alpha(2)-AP(+/+) mice is capable of preventing fibrin deposition after vascular injury and suggest that alpha(2)-AP does not play a major role in smooth muscle cell migration and neointima formation in vivo. Topics: Actins; alpha-2-Antiplasmin; Animals; Elastin; Electric Injuries; Female; Femoral Artery; Fibrin; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2000 |
An experimental model for the study of venous thrombosis in vivo.
Topics: Animals; Blood Coagulation; Disease Models, Animal; Dogs; Electric Injuries; Electrodes; Electrophoresis, Polyacrylamide Gel; Femoral Vein; Fibrin; Ligation; Platelet Aggregation; Pulmonary Embolism; Thrombophlebitis | 1974 |
[Studies of the pathogenesis of arterial occlusive diseases. I. A new method for the study of early changes in the vascular wall].
Topics: Animals; Blood Platelets; Carotid Arteries; Carotid Artery Diseases; Carotid Artery Injuries; Electric Injuries; Fibrin; Male; Methods; Microscopy, Electron; Rabbits | 1968 |