fibrin and Diseases-in-Twins

fibrin has been researched along with Diseases-in-Twins* in 2 studies

Other Studies

2 other study(ies) available for fibrin and Diseases-in-Twins

Article	Year
Genetics of fibrin clot structure: a twin study. Blood, 2004, Mar-01, Volume: 103, Issue:5 Coronary artery thrombosis following plaque rupture is an important feature of myocardial infarction, and studies have highlighted the role of coagulation in this condition. Although genetic and environmental influences on the variance in coagulation protein concentrations have been reported, there are no data on the heritability of structure/function of the final phenotype of the coagulation cascade, the fibrin clot. To assess genetic and environmental contributions to fibrin structure, permeation and turbidity studies were performed in 137 twin pairs (66 monozygotic, 71 dizygotic). The environmental influence (e2) on pore size (Ks) (e2 = 0.61 [95% confidence interval (CI), 0.45-0.80]) and fiber size (e2 = 0.54 [95% CI, 0.39-0.73]) was greater than the heritability (h2 = 0.39 [95% CI, 0.20-0.55] and 0.46 [95% CI, 0.27-0.62], respectively). After correction for fibrinogen levels, the environmental effect persisted for Ks (e2 = 0.61), but genetic influence assumed a greater importance in determining fiber size (h2 = 0.73). Multivariate analysis revealed an overlap in the influence of genetic and environmental factors on fibrinogen levels, Ks, and fiber size. Factor XIII B subunit showed environmental and genetic correlation with fibrinogen and fiber size and a genetic correlation with Ks. The results indicate that genetic and environmental influences are important in determining fibrin clot structure/function. Topics: Adolescent; Adult; Aged; Blood Coagulation; Coronary Vessels; Diseases in Twins; Environment; Factor XIII; Female; Fibrin; Fibrinogen; Humans; Middle Aged; Multivariate Analysis; Phenotype; Thrombosis; Time Factors; Twins, Dizygotic; Twins, Monozygotic	2004
[Local and generalized Sanarelli-Shwartzman phenomenon in the human fetal organism]. Virchows Archiv fur pathologische Anatomie und Physiologie und fur klinische Medizin, 1967, Volume: 343, Issue:2 Topics: Adult; Chemical Precipitation; Choroiditis; Diseases in Twins; Endotoxins; Escherichia coli Infections; Extraembryonic Membranes; Female; Fetal Death; Fetal Diseases; Fibrin; Humans; Infant, Newborn; Infant, Premature, Diseases; Obstetric Labor, Premature; Photomicrography; Placenta; Pregnancy; Pregnancy Complications, Infectious; Rupture; Shwartzman Phenomenon	1967

Article

Year

Genetics of fibrin clot structure: a twin study.

Blood, 2004, Mar-01, Volume: 103, Issue:5

Coronary artery thrombosis following plaque rupture is an important feature of myocardial infarction, and studies have highlighted the role of coagulation in this condition. Although genetic and environmental influences on the variance in coagulation protein concentrations have been reported, there are no data on the heritability of structure/function of the final phenotype of the coagulation cascade, the fibrin clot. To assess genetic and environmental contributions to fibrin structure, permeation and turbidity studies were performed in 137 twin pairs (66 monozygotic, 71 dizygotic). The environmental influence (e2) on pore size (Ks) (e2 = 0.61 [95% confidence interval (CI), 0.45-0.80]) and fiber size (e2 = 0.54 [95% CI, 0.39-0.73]) was greater than the heritability (h2 = 0.39 [95% CI, 0.20-0.55] and 0.46 [95% CI, 0.27-0.62], respectively). After correction for fibrinogen levels, the environmental effect persisted for Ks (e2 = 0.61), but genetic influence assumed a greater importance in determining fiber size (h2 = 0.73). Multivariate analysis revealed an overlap in the influence of genetic and environmental factors on fibrinogen levels, Ks, and fiber size. Factor XIII B subunit showed environmental and genetic correlation with fibrinogen and fiber size and a genetic correlation with Ks. The results indicate that genetic and environmental influences are important in determining fibrin clot structure/function.

Topics: Adolescent; Adult; Aged; Blood Coagulation; Coronary Vessels; Diseases in Twins; Environment; Factor XIII; Female; Fibrin; Fibrinogen; Humans; Middle Aged; Multivariate Analysis; Phenotype; Thrombosis; Time Factors; Twins, Dizygotic; Twins, Monozygotic

2004

[Local and generalized Sanarelli-Shwartzman phenomenon in the human fetal organism].

Virchows Archiv fur pathologische Anatomie und Physiologie und fur klinische Medizin, 1967, Volume: 343, Issue:2

Topics: Adult; Chemical Precipitation; Choroiditis; Diseases in Twins; Endotoxins; Escherichia coli Infections; Extraembryonic Membranes; Female; Fetal Death; Fetal Diseases; Fibrin; Humans; Infant, Newborn; Infant, Premature, Diseases; Obstetric Labor, Premature; Photomicrography; Placenta; Pregnancy; Pregnancy Complications, Infectious; Rupture; Shwartzman Phenomenon

1967