fibrin and Cross-Infection

Topics: Anti-Bacterial Agents; Ascorbic Acid; Collagen; Cross Infection; Debridement; Diet; Fibrin; Granulation Tissue; Humans; Surgical Instruments; Surgical Wound Dehiscence; Surgical Wound Infection; Sutures; Tissue Adhesives; Wound Healing; Wounds and Injuries; Zinc

Topics: Bacteria; Blood Banks; Cross Infection; Fibrin; Humans; Orthopedics; Risk Assessment; Transfusion Reaction

With the possible exception of pulmonary artery catheters, central venous catheters (CVCs) have the highest rates of infection of all intravascular catheters, accounting for up to 90% of all vascular catheter-related bloodstream infections. The frequency of CVC-related infections is between 10-30%.

Topics: Catheterization, Central Venous; Catheters, Indwelling; Cross Infection; Device Removal; Equipment Contamination; Fibrin; Humans

The purpose of the study was do describe the architecture of accretions occurring on the tips of central venous catheters (CVC).. A conservative procedure was used followed by two different techniques of electron microscopy.. the study included 19 catheters which have been used on intensive cared adults, and which were chosen among those of parallel 300 CVC study.. CVC were considered sterile, contaminated, colonized or infected according to microbiological and clinical criteria. CVC were found to remain much cleaner than in past descriptions. When present, accretions were located on the olive-shaped end, and displayed stratified structures with three types of material: amorphous material, thrombus components and inflammatory cells. Bacteria were not seen, even on culture positive CVC. Candida albicans was found on one CVC in the cytoplasm of granulocytes, and made no direct contact with the plastic surface.. This technique should contribute to the understanding of the pathobiology of CVC infection and provide information proving or precluding the involvement of microbial adherence to polymers in vivo.

Topics: Anti-Bacterial Agents; Bacterial Adhesion; Candida albicans; Catheterization, Central Venous; Catheters, Indwelling; Colony Count, Microbial; Cross Infection; Equipment Contamination; Equipment Design; Evaluation Studies as Topic; Fibrin; France; Humans; Infusions, Intravenous; Intensive Care Units; Microscopy, Electron, Scanning; Microscopy, Electron, Scanning Transmission; Time Factors

Topics: Cross Infection; Fibrin; Hepatitis B; Hepatitis B Antibodies; Hepatitis C; Humans; Risk; Tissue Adhesives

A major problem in total parenteral nutrition is sepsis, particularly that caused by Candida. Studies of four solutions, a casein hydrolysate, a fibrin hydrolysate, and two crystalline amino acid solutions, show that the protein hydrolysate solutions appear to be highly selective for Candida over bacteria, whereas the crystalline amino acid solutions are not. These findings suggest that the crystalline amino acid preparations may offer a partial solution to the infection problem by minimizing the contribution of the solution as a reservoir for organism multiplication, because they retard the growth of both bacteria and Candida.

Topics: Amino Acids; Bacteria; Candida; Caseins; Cell Count; Cross Infection; Crystallography; Enterobacter; Enterobacteriaceae; Erwinia; Escherichia coli; Fibrin; Glucose; Humans; Klebsiella pneumoniae; Parenteral Nutrition; Protein Hydrolysates; Pseudomonas aeruginosa; Serratia marcescens; Staphylococcus