fibrin and Coma

A procoagulant state is implicated in cerebral malaria (CM) pathogenesis, but whether disseminated intravascular coagulation (DIC) is present or associated with a fatal outcome is unclear.. To determine the frequency of overt DIC, according to ISTH criteria, in children with fatal and non-fatal CM.. Malawian children were recruited into a prospective cohort study in the following diagnostic groups: retinopathy-positive CM (n = 140), retinopathy-negative CM (n = 36), non-malarial coma (n = 14), uncomplicated malaria (UM), (n = 91), mild non-malarial febrile illness (n = 85), and healthy controls (n = 36). Assays in the ISTH DIC criteria were performed, and three fibrin-related markers, i.e. protein C, antithrombin, and soluble thrombomodulin, were measured.. Data enabling assignment of the presence or absence of 'overt DIC' were available for 98 of 140 children with retinopathy-positive CM. Overt DIC was present in 19 (19%), and was associated with a fatal outcome (odds ratio [OR] 3.068; 95% confidence interval [CI] 1.085-8.609; P = 0.035]. The levels of the three fibrin-related markers and soluble thrombomodulin were higher in CM patients than in UM patients (all P < 0.001). The mean fibrin degradation product level was higher in fatal CM patients (71.3 μg mL(-1) [95% CI 49.0-93.6]) than in non-fatal CM patients (48.0 μg mL(-1) [95% CI 37.7-58.2]; P = 0.032), but, in multivariate logistic regression, thrombomodulin was the only coagulation-related marker that was independently associated with a fatal outcome (OR 1.084 for each ng mL(-1) increase [95% CI 1.017-1.156]; P = 0.014). Despite these laboratory derangements, no child in the study had clinically evident bleeding or thrombosis. An overt DIC score and high thrombomodulin levels are associated with a fatal outcome in CM, but infrequently indicate a consumptive coagulopathy.

Topics: Biomarkers; Blood Glucose; Child; Child, Preschool; Coma; Disseminated Intravascular Coagulation; Female; Fever; Fibrin; Hematologic Tests; Humans; Infant; Lactates; Malaria, Cerebral; Malaria, Falciparum; Malawi; Male; Parasitemia; Prospective Studies; Retinal Hemorrhage; Risk Factors; Thrombomodulin

Prolonged coma due to acute overdosage with hypnotic drugs is shown to be associated with a pronounced increase in the activity of serum creatine kinase and in the concentration of fibrin degradation products and with less pronounced abnormalities of other serum enzymes and of other indices of coagulation and fibrinolysis. Evidence is presented that skeletal muscle damage occurs and that this is related to the coagulation abnormality. These findings probably explain some of the non-specific features such as fever which commonly occur in recovery from severe poisoning.

Topics: Adult; Aged; Alanine Transaminase; Amitriptyline; Aspartate Aminotransferases; Blood Coagulation; Blood Platelets; Coma; Creatine Kinase; Enzymes; Female; Fever; Fibrin; Fibrinogen; Fibrinolysis; Humans; Hydroxybutyrate Dehydrogenase; Hypnotics and Sedatives; L-Lactate Dehydrogenase; Male; Middle Aged; Muscular Diseases; Plasminogen; Serum Globulins