fibrin and Collagen-Diseases

Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Collagen Diseases; Fibrin; Humans; Kidney; Leukocyte Count; Lupus Erythematosus, Systemic; Myocardium; Rheumatic Fever; Rheumatoid Factor; Skin; Synovial Membrane

Topics: Collagen Diseases; Cysteine; Extracellular Space; Fibrin; Humans; Rheumatoid Nodule; Shwartzman Phenomenon; Tryptophan; Tyrosine

This study examined the clinical significance of intra-alveolar fibrin deposition (IAFD) in transbronchial lung biopsy specimens obtained from patients with organizing pneumonia.. Pathological reports of transbronchial lung biopsies performed between 2004 and 2012 were reviewed to identify cases of intra-alveolar organization with or without fibrin deposition. Clinical charts, computed tomography images, and transbronchial lung biopsy specimens from these cases were examined retrospectively. Diagnosis of organizing pneumonia was reevaluated based upon the consensus of a respiratory physician, a radiologist, and a pathologist.. Transbronchial lung biopsy results of the reviewed patients with organizing pneumonia found seven patients who had IAFD, and 34 who did not. Seven patients' conditions were associated with collagen vascular disease (CVD), and 34 were cryptogenic. IAFD was significantly associated with high C-reactive protein (CRP) values (>5 mg/dl) (p = 0.0012) and underlying CVD (p = 0.0099). Multivariate analysis revealed that IAFD was independently associated with high CRP values (p = 0.0184). Three of 31 patients and six of 27 patients experienced a relapse of organizing pneumonia within 6 months and 1 year, respectively. IAFD (p = 0.0044) and high CRP values (p = 0.0207) were significantly related to relapse within 6 months, while only CRP was significantly related to relapse within 1 year (p = 0.0007).. In patients with organizing pneumonia, IAFD was significantly associated with high CRP values. High CRP values and/or IAFD predicted relapse of organizing pneumonia within 6 months to 1 year.

Topics: Aged; Biopsy; C-Reactive Protein; Collagen Diseases; Female; Fibrin; Humans; Male; Pneumonia; Pulmonary Alveoli; Radiography; Recurrence; Retrospective Studies; Vascular Diseases

Topics: Collagen Diseases; Fibrin; Humans; Lung; Lung Diseases, Interstitial; Male; Middle Aged; Pneumonia; Pulmonary Alveoli; Vascular Diseases

Topics: Adult; Arthritis, Rheumatoid; Collagen Diseases; Factor XIII; Female; Fibrin; Fibrin Fibrinogen Degradation Products; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Raynaud Disease

Neuropathologic examination of an autopsy series of 54 patients of various types of CVD revealed a very high frequency of pathologic changes both in brain parenchyma (in 81%) and vessels (in 78%). A broad but continuous spectrum of primary vascular alterations was observed, ranging from fibrinoid deposits in intact or necrotizing vessel walls to fibrohyalinosis and endothelial proliferations. In acute SLE showing LE cells within brain tissues, immune complex deposits were observed for the first time in brain vessels, in addition to similar deposits in the plexus chorioideus and in hematoxylin bodies. Secondary complications are frequently affecting the brain in CVD; they are mainly sequels of systemic atherosclerosis, hypertension, thromboemboli from SLE endocarditis, cardiac, hepatic or renal dysfunctions, or infections and should be clinically differentiated from primary brain involvement in CVD to ensure the appropriate therapeutic measures.

Topics: Arthritis, Rheumatoid; Brain; Cerebral Arteries; Collagen Diseases; Complement C3; Fibrin; Humans; Immunoglobulin G; Lupus Erythematosus, Systemic; Myositis; Polyarteritis Nodosa; Purpura, Thrombotic Thrombocytopenic; Vascular Diseases; Vasculitis

Plasminogen-free fibrin plate (fP) which was made from treated commerical bovine fibrinogen with Lysine-Sepharose was developed in our laboratory. This new fibrin plate showed the following specificities. a) This new fibrin plate did not show any lysis with high amount of streptokinase and Urokinase (10,000 u/ml and 500 u/ml). b) The concentrations of its substrate was the same as standard plate (SP) and its substrate was not denatured compared with heated plate (HP). c) The activity of plasmin can be measured quantitatively on fP and linear correlation between plasmin units and lysis area was showen. d) This procedure of new fibrin plate was easy and simple and could be applicable to the materials of other species, i.e., human, rabbit and porcine. With the use of two kinds of bovine fibrin plate (SP and fP), activation of fibrinolysis of human plasma, euglobulin and plasminogen induced by SK and UK was investigated and each correlation ship between sample and activator was studied statistically. From these results, "Index of fibrinolysis" meaning of fibrinolytic components such as plasmin, plasminogen, activator, proactivator, anti-activator and anti-plasmin were indicated. Indeed, these index of fibrinolysis were calculated from the lysis area of plasma+SK, Eug.+SK and Eug.+UK by each formula and index obtained from some physiological and pathological condition showed us many new information about fibrinolysis.

Topics: Animals; Arthritis, Rheumatoid; Collagen Diseases; Fibrin; Fibrinogen; Fibrinolysin; Fibrinolysis; Hot Temperature; Humans; Methods; Physical Exertion; Plasminogen; Plasminogen Activators; Serum Globulins; Solubility; Streptokinase; Urokinase-Type Plasminogen Activator

The vascular brain plexi were studied in 40 cases of rheumatism, 18 cases of systemic lupus vulgaris, 12 cases of nodus periarthritis and 5 cases of sclerodermia. In all cases there were phenomena of a desorganization of the connective tissue in the stroma and vascular walls accompanied by a significant accumulation of acid mucopolysaccharides, panvasculitis, thrombovasculitis, necrobiotic changes of the chorioid epithelium and nervous filaments. The authors report of special traits of structural changes inherent in each disease.

Topics: Adolescent; Adult; Child; Choroid Plexus; Collagen Diseases; Fibrin; Glycosaminoglycans; Histocytochemistry; Humans; Middle Aged

Topics: Aged; Arthritis, Rheumatoid; Blood Cell Count; Blood Platelets; Carbon Radioisotopes; Collagen Diseases; Factor XIII; Female; Fibrin; Fibrinolysis; Heart Failure; Humans; Hypertension, Malignant; Infections; Leukemia; Liver Diseases; Neoplasms; Pulmonary Embolism; Sepsis; Streptokinase

Topics: Abortion, Missed; Abruptio Placentae; Blood Coagulation Tests; Collagen Diseases; Erythrocytes; Esters; Female; Fibrin; Fibrinolysis; Fluorides; Hemagglutination Inhibition Tests; Humans; Kidney Diseases; Latex Fixation Tests; Leukemia; Ovarian Neoplasms; Pre-Eclampsia; Pregnancy; Pyruvates; Shock; Staphylococcus; Uterine Neoplasms

Topics: Arthritis, Rheumatoid; Autopsy; Collagen Diseases; Dermatomyositis; Diagnosis, Differential; Fibrin; Granuloma; Histocytochemistry; Humans; Lung; Lupus Erythematosus, Systemic; Polyarteritis Nodosa; Pulmonary Alveoli; Pulmonary Fibrosis; Rheumatic Fever; Scleroderma, Systemic

Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Cartilage; Collagen Diseases; Connective Tissue; Dermatomyositis; Fibrin; Giant Cell Arteritis; Humans; Lupus Erythematosus, Systemic; Rheumatic Fever; Scleroderma, Systemic

Topics: Animals; Behcet Syndrome; Collagen; Collagen Diseases; Cornea; Eye; Eye Diseases; Fibrin; Fibrinogen; Fluorescent Antibody Technique; Glaucoma; Humans; Rabbits; Uveitis

Topics: Capillary Permeability; Cell Membrane Permeability; Collagen Diseases; Fibrin; Humans

Topics: Animals; Collagen Diseases; Connective Tissue; Female; Fibrin; Microscopy, Electron; Rabbits; Rats; Skin

Topics: Collagen Diseases; Fibrin; Humans; In Vitro Techniques

Topics: Alpha-Globulins; Anemia; Biological Assay; Biomedical Research; Blood Coagulation; Blood Coagulation Factors; Calcium; Collagen Diseases; Cysteine; Factor XIII; Fibrin; Hemorrhagic Disorders; Humans; Leukemia; Liver; Liver Diseases; Lymphoma; Neoplasms; Pathology; Serum Globulins; Sulfhydryl Compounds; Thrombin

Topics: Anemia; Anemia, Hypochromic; Biomedical Research; Blood Chemical Analysis; Collagen Diseases; Enzyme Inhibitors; Fibrin; Hemophilia A; Hepatitis; Hepatitis A; Jaundice; Jaundice, Obstructive; Leukemia; Liver Cirrhosis; Multiple Myeloma; Nephritis; Nephrotic Syndrome; Physiology; Purpura; Thrombin; Uremia

Topics: Collagen Diseases; Fibrin; Humans

Topics: Collagen Diseases; Fibrin; Humans

Topics: Animals; Cardiovascular System; Collagen Diseases; Disease; Fibrin; Humans; Hypersensitivity; Immune System Diseases; Lagomorpha; Rabbits

Topics: Collagen Diseases; Connective Tissue; Fibrin; Humans; Leiomyoma