fibrin has been researched along with Carcinoma--Ehrlich-Tumor* in 4 studies
4 other study(ies) available for fibrin and Carcinoma--Ehrlich-Tumor
Article | Year |
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Importance of viability and attachment to an ascites tumor in the release of plasminogen activator.
Tumor plasminogen activator (PA) has been alleged to play a role in the growth and metastasis of tumors. Before such a role can be realized, PA first must be released from tumor cells. Having determined intra- and extracellular PA and PA-inhibitor activities in an experimental pancreatic ascites tumor grown in hamsters, the release of PA from these cells was investigated. No PA activity was detected in the suspension medium of freshly isolated tumor cells; inclusion of plasminogen, fibrinogen, or collagen in the medium yielded similar negative results. On the other hand, PA activity was demonstrated to be released in a time-dependent manner from these tumor cells embedded in fibrin clots. Plasminogen activator activity also was not found in the suspension medium of frozen-thawed tumor cells, despite the fact that most of them had breaks on their cell membrane. Unlike freshly isolated tumor cells, PA was not released from frozen-thawed cells embedded in fibrin clots. Full PA activity was demonstrated in frozen-thawed cells treated with Triton X-100, however. Frozen-thawed cells exhibited signs of severe damage, and more than 80% of them failed to exclude trypan blue. Obviously PA is released from viable tumor cells embedded in fibrin clots but not suspended in artificial medium. The PA-release mechanism, not PA itself, is destroyed in cells rendered nonviable by freeze thawing. Topics: Animals; Blood Coagulation; Carcinoma, Ehrlich Tumor; Cell Adhesion; Cell Survival; Cricetinae; Fibrin; Male; Mesocricetus; Microscopy, Electron; Octoxynol; Pancreatic Neoplasms; Polyethylene Glycols; Time Factors; Tissue Plasminogen Activator; Tumor Cells, Cultured | 1991 |
Occlusion of basic proteins by fibrin: studies with 14C-arginine labelled proteins.
Topics: Animals; Arginine; Blood Coagulation; Blood Proteins; Carcinoma, Ehrlich Tumor; Fibrin; Fibrinolysis; Isoelectric Point; Neoplasm Proteins; Thrombin | 1980 |
The fibrinogen-fibrin system in human intracranial tumor tissues: an immunohistological study.
Topics: Animals; Antigens; Brain Neoplasms; Carcinoma, Ehrlich Tumor; Fibrin; Fibrinogen; Fluorescent Antibody Technique; Glioblastoma; Glioma; Humans; Immunodiffusion; Immunoelectrophoresis; Iodine Isotopes; Meningioma; Mice; Neoplasms, Experimental; Plasminogen; Rabbits; Radiometry; Radionuclide Imaging; Rats; Sarcoma, Yoshida | 1969 |
STUDIES ON THE FIBRINOLYSIS IN TUMOR BEARING MICE. II. APPEARANCE OF FIBRINOLYTIC ENZYME IN ASCITES AFTER TUMOR CELLS INOCULATION.
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; Fibrin; Fibrinolysis; Globulins; Mice; Neoplasms; Neoplasms, Experimental; Physiology; Research | 1963 |