fibrin and Blindness

Topics: Blindness; Blood Platelets; Embolism; Female; Fibrin; Humans; Middle Aged; Ophthalmoscopy; Radiography; Retinal Artery Occlusion; Vision, Monocular

Eighty-five patients with retinal emboli, visible ophthalmoscopically, were studied retrospectively. All the patients had presented with transient or permanent visual loss. Follow up from the time of presentation was one year to 12 years with a mean of 4.5 years. Life expectancy in the 58 medically treated patients who presented with cholesterol emboli was significantly reduced (p = 0.028). Stroke was the commonest cause of death and was significantly more frequent than in the general population (p less than 0.001); there was also an increased total incidence of cerebrovascular disease (fatal and non-fatal) compared with the Oxfordshire Stroke Project (p less than 0.001). The mortality from ischaemic heart disease was not significantly increased. We report a series of 85 patients with retinal emboli, 69 of whom had cholesterol emboli (70 fundi), 15 calcific emboli and one platelet-fibrin embolus. The natural history of medically treated patients with cholesterol emboli is compared both with an age and sex matched population and with patients with amaurosis fugax but no visible retinal emboli.

Topics: Adult; Aged; Aged, 80 and over; Blindness; Calcinosis; Cholesterol; Embolism; Female; Fibrin; Humans; Male; Middle Aged; Platelet Aggregation; Prognosis; Retinal Artery; Retinal Diseases; Risk Factors

Report on a case of amaurosis fugax during which the wandering of a fibrin platelet embolus through the vessels of the central arteria was photographed.

Topics: Blindness; Carotid Artery Thrombosis; Embolism; Fibrin; Fluorescein Angiography; Humans; Male; Middle Aged; Platelet Aggregation; Retinal Vessels

Topics: Animals; Antioxidants; Blindness; Choroid; Darkness; Diet; Fatty Acids; Fibrin; Hydrophthalmos; Light; Lipid Metabolism; Macrophages; Melanins; Oxidation-Reduction; Peroxides; Photochemistry; Retina; Retinal Degeneration; Retinal Detachment; Time Factors; Turkeys

Topics: Angiomatosis; Anticoagulants; Arm; Biopsy; Blindness; Blood Coagulation Disorders; Capillaries; Chronic Disease; Factor V; Factor VIII; Female; Fibrin; Fibrinolysin; Humans; Leg Dermatoses; Middle Aged; Pain; Prednisolone; Skin Manifestations; Skin Ulcer; Thrombosis

Topics: Blindness; Blood Platelets; Carotid Artery Thrombosis; Carotid Artery, Internal; Cerebral Infarction; Embolism; Endarteritis; Fibrin; Hemiplegia; Humans; Intracranial Embolism; Intracranial Embolism and Thrombosis; Ischemic Attack, Transient; Leukocytes; Retinal Vessels; Thrombosis

Topics: Blindness; Deoxyribonuclease I; Fibrin; Humans; Streptodornase and Streptokinase; Streptokinase; Tuberculosis; Tuberculosis, Meningeal