fibrin and Atrophy

The rehabilitation of edentulous posterior maxilla is a challenging task that could be complicated by the availability of low-density and reduced height of alveolar bone. Patients were enrolled in this study upon the presence of type IV bone and residual bone height <5 mm in posterior maxilla. Novel procedure for transalveolar sinus floor elevation was described to insert 10 short implants in 4 patients. Neither implant failure nor prosthetic failure was observed during a follow-up of 44 ± 3 months. Mesial bone loss of 0.5 ± 0.6 mm and a distal bone loss 1.3 ± 0.9 mm were measured after 35 ± 4 months of loading.

Topics: Alveolar Process; Atrophy; Bone Density; Cone-Beam Computed Tomography; Dental Implantation, Endosseous; Dental Implants; Dental Prosthesis Design; Dental Prosthesis, Implant-Supported; Denture, Partial, Fixed; Fibrin; Follow-Up Studies; Humans; Jaw, Edentulous, Partially; Maxilla; Middle Aged; Patient Care Planning; Sinus Floor Augmentation; Treatment Outcome

Maxillary bone losses often require additional regenerative procedures: as a supplement to the procedures of tissue regeneration, a platelet concentrate called PRF (Platelet Rich Fibrin) was tested for the first time in France by Dr. Choukroun. Aim of the present study is to investigate, clinically and histologically, the potential use of PRF, associated with deproteinized bovine bone (Bio-Oss), as grafting materials in pre-implantology sinus grafting of severe maxillary atrophy, in comparison with a control group, in which only deproteinized bovine bone (Bio-Oss) was used as reconstructive material.. 60 patients were recruited using the cluster-sampling method; inclusion criteria were maxillary atrophy with residual ridge < 5mm. The major atrophies in selected patients involved sinus-lift, with a second-look reopening for the implant insertion phase. The used grafting materials were: a) Bio-Oss and b) amorphous and membranous PRF together with Bio-Oss. We performed all operations by means of piezosurgery in order to reduce trauma and to optimize the design of the operculum on the cortical bone. The reopening of the surgical area was scheduled at 3 different times.. 72 sinus lifts were performed with subsequent implants insertions.We want to underline how the histological results proved that the samples collected after 106 days (Early protocol) with the adding of PRF were constituted by lamellar bone tissue with an interposed stroma that appeared relaxed and richly vascularized.. The use of PRF and piezosurgery reduced the healing time, compared to the 150 days described in literature, favoring optimal bone regeneration. At 106 days, it is already possible to achieve good primary stability of endosseous implants, though lacking of functional loading.

Topics: Adult; Animals; Atrophy; Bone Regeneration; Cattle; Dental Implantation, Endosseous; Female; Fibrin; France; Humans; Male; Mandibular Reconstruction; Maxilla; Maxillary Sinus; Middle Aged; Minerals; Piezosurgery; Platelet-Rich Plasma

The use of bone substitutes in massive sinus-lift pre-implant procedures remains controversial. The aim of our study was to evaluate the long-term reliability of pure-phase beta-tricalcium phosphate (betaTCP, Cerasorb, Curasan, Kleinostheim, Germany) used in this particular indication.. Twenty patients (33sinus) presenting with severe sinus floor atrophy (class 4 to 6 according to Cawood) and having undergone a sinus lift procedure by mean of betaTCP were followed in a prospective study between January 2002 and May 2008. The surgical approach was classical (under local anesthesia in eight patients) and the sinuses were filled with betaTCP (6 cm3 on average per sinus) and autologous growth factors (platelet rich plasma PRP and platelet rich fibrin PRF, according to the technique described by Dohan and Weibrich). One hundred and twenty-three dental implants were inserted in the grafted sinuses between the fourth and the eighth postoperative month (Nobel Biocare MK III and MK IV-mean length: 12.44 mm) using a 2-step buried technique and loaded between the fourth and the sixth month. Follow-up included regular clinical examination and panoramic X-rays to screen for possible sinus and implant complications. The control X-rays also allowed measuring the biomaterial resorption rate.. The mean postoperative follow-up was 4.5 years for the sinus lift procedures and 4 years for the implants. We noted one case of local infection at the 15th postoperative day (3%). The implant success rate was 97.6% (lack of osteo-integration for two implants in the same patient, one failure after loading). The prosthetic success rate was 100%. The mean resorption rate of the material was 20.3% and the mean gain of height was 16.9 mm.. The use of betaTCP associated to growth factors (PRP ou PRF) without bone graft, in massive sinus-lift procedures induces few complications. The implant success rate is comparable to the one obtained by using autologous bone grafts. The resorption rate of the material is comparable to that of autologous bone.

Topics: Adult; Aged; Alveolar Ridge Augmentation; Atrophy; Biocompatible Materials; Bone Substitutes; Calcium Phosphates; Dental Implantation, Endosseous; Dental Implants; Dental Prosthesis, Implant-Supported; Dental Restoration Failure; Female; Fibrin; Follow-Up Studies; Humans; Longitudinal Studies; Male; Maxilla; Maxillary Sinus; Middle Aged; Osseointegration; Platelet-Rich Plasma; Prospective Studies; Radiography, Panoramic; Surgical Wound Infection; Treatment Outcome

Atrophie blanche is an uncommon condition characterized by the development of white atrophic patches of skin on the lower extremities, which form as a result of fibrinoid vasculitis of superficial and mid-dermal vessels followed by necrosis and ulceration of the epidermis. We report four cases in which similar lesions developed on the legs and ankles of young Jewish Russian immigrants to Israel. Although the lesions share many features with atrophie blanche, they differ in their early age of onset, the male predilection, and the extension of the fibrinoid vasculitic process into the subcutaneous tissue. Additionally, the peculiar population clustering (Georgia, U.S.S.R.), common ethnic background, and a family history of similar lesions in close relatives seem to point to a familial or genetic predisposition underlying the development of the disease.

Topics: Adolescent; Adult; Atrophy; Biopsy; Capillaries; Female; Fibrin; Humans; Leg Ulcer; Male; Necrosis; Skin; Skin Ulcer; Vasculitis

A 48-year-old man with accelerated hypertension developed right-sided ischemic colitis. There was no evidence of another cause of vascular inadequacy. Microscopically, the bowel showed ischemic alterations of different stages. The arterial alterations of different stages. The arterial vessels showed minimal changes. In older lesions, fibrosis was prominent and the mucosa was atrophic. In more recent lesions, some vessels of the submucosa were plugged with fibrin and the overlying mucosa was infiltrated by nonorganized hemorrhage and cellular elements.

Topics: Arteries; Atrophy; Colitis; Colon; Fibrin; Gastrointestinal Hemorrhage; Humans; Hypertension; Intestinal Mucosa; Ischemia; Male; Middle Aged

Hyalinizing segmental vasculitis or livedo vasculitis (atrophie blanche) is a clinical entity with a distinctive immunohistopathologic morphology that can be distinguished from other forms of cutaneous vasculitis by histologic and direct immunofluorescent studies. Our studies showed that immunoglobulins and complement components (C-1g, C-3, and properdin) were localized in diseased vessel walls, suggesting an immune pathogenesis.

Topics: Atrophy; Biopsy; Blood Vessels; Complement System Proteins; Extremities; Fibrin; Fluorescent Antibody Technique; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Properdin; Skin; Vascular Diseases

Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Atrophy; Dogs; Edema; Electron Transport Complex IV; Epithelium; Female; Fibrin; Histocytochemistry; Ileum; Inflammation; Intestinal Mucosa; L-Lactate Dehydrogenase; Succinate Dehydrogenase; Time Factors; Urinary Bladder; Urinary Diversion

Topics: Atrophy; Extraembryonic Membranes; Female; Fibrin; Gestational Age; Humans; Pregnancy

Topics: Abortion, Induced; Atrophy; Cesarean Section; Extraembryonic Membranes; Female; Fibrin; Humans; Labor, Obstetric; Obstetric Labor Complications; Obstetric Labor, Premature; Obstetrics; Pathology; Placenta; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Trimester, Second; Uterine Hemorrhage