fibrin and Anuria

Topics: Angiography; Animals; Anuria; Cadaver; Diuresis; Dogs; Fibrin; Glomerular Filtration Rate; Graft Rejection; Humans; Hypertension, Renal; Kidney; Kidney Glomerulus; Kidney Transplantation; Kidney Tubules; Postoperative Complications; Proteinuria; Thrombosis; Time Factors; Tissue Preservation; Transplantation Immunology; Transplantation, Autologous; Transplantation, Homologous

Topics: ABO Blood-Group System; Adolescent; Adult; Anuria; Biopsy, Needle; Blood Group Incompatibility; Female; Fibrin; Histocompatibility Testing; Humans; Immunoglobulin G; Immunosuppressive Agents; Kidney Glomerulus; Kidney Transplantation; Male; Splenectomy; T-Lymphocytes; Thrombosis

Four patients had clinical manifestations of the hemolytic-uremic syndrome. No evidence of active intravascular coagulation was found during the acute phase of the illness, using a sensitive assay to measure soluble circulating fibrin in the plasma of these patients, three of whom developed the clinical syndrome while hospitalized for gastro-enteritis. These findings, coupled with the findings of others, suggest that either the episode of intravascular coagulation precedes the development of the clinical manifestations, or that platelet thrombosis is occurring in the absence of activation of plasma clotting factors. In any case, heparin anticoagulant therapy does not seem indicated.

Topics: Anuria; Blood Cell Count; Blood Coagulation Tests; Blood Platelets; Blood Pressure; Blood Urea Nitrogen; Carbon Radioisotopes; Child; Child, Preschool; Creatinine; Disseminated Intravascular Coagulation; Factor V; Factor VIII; Female; Fibrin; Fibrinogen; Hematuria; Hemoglobins; Hemolytic-Uremic Syndrome; Heparin; Humans; Infant; Male; Proteinuria; Prothrombin Time; Thromboplastin; Thrombosis

The urinary excretion of fibrin/fibrinogen degradation products (F.D.P.) of 81 human cadaver kidney transplants has been measured serially by the techniques of tanned red cell haemagglutination inhibition immunoassay and immunonephelometry. Acute rejection episodes in functioning transplants have been associated with increased F.D.P. excretion which in 80% of cases has preceded clinical diagnosis by periods of one to seven days. Recovery from these episodes has been associated with a rapid fall of F.D.P. excretion to undetectable levels. The level of F.D.P. excretion during a rejection episode is a guide to its ultimate outcome. Irreversibly rejected kidneys excrete high levels of F.D.P. for long periods. Viable kidney transplants with prolonged oliguric phases can be distinguished, while still oliguric, from rejected kidneys by their low F.D.P. excretion. F.D.P. cannot usually be detected in the urine of well-functioning transplants. Episodes of raised F.D.P. excretion in the absence of acute clinical rejection, however, occur occasionally and may be associated with permanent impairment of renal function.

Topics: Anuria; Cadaver; Creatinine; Fibrin; Fibrinogen; Graft Rejection; Hemagglutination Inhibition Tests; Humans; Hypertension; Kidney Transplantation; Transplantation, Homologous; Urea

Topics: Abruptio Placentae; Acute Kidney Injury; Animals; Anuria; Disseminated Intravascular Coagulation; Female; Fibrin; Iodine Radioisotopes; Kidney; Kidney Glomerulus; Mercury Poisoning; Methemoglobin; Pregnancy; Rabbits; Shock; Shwartzman Phenomenon; Tourniquets

Topics: Anuria; Disseminated Intravascular Coagulation; Escherichia coli Infections; Fibrin; Humans; Kidney Failure, Chronic; Sepsis

Topics: Acute Kidney Injury; Anemia, Hemolytic; Anuria; Blood Cell Count; Blood Coagulation Factors; Blood Transfusion; Central Nervous System Diseases; Disseminated Intravascular Coagulation; Erythrocytes, Abnormal; Fibrin; Hematuria; Hemoglobins; Hemolysis; Heparin; Humans; Hyperkalemia; Infant; Kidney; Kidney Glomerulus; Peritoneal Dialysis; Thrombocytopenia

Topics: Aged; Anuria; Cystitis; Diverticulum; Duodenal Ulcer; Female; Fibrin; Hernia, Inguinal; Humans; Ileum; Laparotomy; Male; Necrosis; Peritonitis; Rupture, Spontaneous; Tuberculosis, Urogenital; Urinary Bladder Calculi; Urinary Bladder Diseases; Urinary Bladder Neoplasms; Urination Disorders; Urography

Topics: Abruptio Placentae; Adult; Animals; Anuria; Bilirubin; Blood Coagulation Disorders; Dogs; Erythrocytes; Female; Fibrin; Fibrinolysis; Hematologic Diseases; Hemolysis; Humans; Mice; Pregnancy; Rabbits; Rats; Shock, Hemorrhagic; Thrombin; Thromboplastin