fibrin and Angiolipoma

Oral angiolipomas are exceedingly rare and little is known about their morphological and etiological features. Here, we report two cases of oral angiolipoma and discuss their clinicopathological and immunohistochemical features, focusing on endothelial markers. Both lesions presented mature adipocytes interspersed by small blood vessels containing fibrin thrombi. Immunohistochemical analysis showed numerous mast cells and expression of CD34, vascular endothelial growth factor, intercellular adhesion molecule-1, interferon-γ and interleukin 6 in most endothelial and stromal cells. Mast cell-endothelial cell interaction may be responsible for the reactive or neoplastic origin of the vascular proliferation of these entities.

Topics: Adipocytes; Adult; Angiolipoma; Antigens, CD34; Endothelial Cells; Endothelium, Vascular; Female; Fibrin; Follow-Up Studies; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-6; Male; Mast Cells; Microvessels; Middle Aged; Mouth Neoplasms; Stromal Cells; Thrombosis; Vascular Endothelial Growth Factor A

We describe an unusual and rare case of a lipoma variant known as angiofibrolipoma. A literature search revealed only a few cases of angiofibrolipoma which were located in different anatomical sites; no case of angiofibrolipoma in the oral cavity has been previously reported. We present and discuss the histopatholological-immunohistological findings and features. Angiofibrolipoma histologically consists of mature adipocytes, blood vessels, and bundles of collagenous connective tissue with low to moderate cellularity. It is not encapsulated, but is histologically distinct from surrounding tissue. Positive immunohistological staining with CD-34 presented a large number of blood vessels of different sizes located between collagen fibers and adipocytes. The treatment of choice for a patient with angiofibrolipoma is surgical excision, which is expected to be curative.

Topics: Adipocytes; Adult; Angiofibroma; Angiolipoma; Antigens, CD34; Capillaries; Collagen; Connective Tissue; Fibrin; Gingival Neoplasms; Humans; Male

A 25-year-old man had a 5-year history of multiple tender lesions of both extremities and trunk. Biopsy found an encapsulated subcutaneous nodule composed of numerous small, well-formed blood vessels, some filled with fibrin thrombi. This lesion was made up > 99.9% of blood vessels with only a minimal amount of adipose tissue. We believe our case is in the spectrum of angiolipoma even though it is made up almost entirely of a vascular component. These tumors may be confused with other multiple or eruptive vascular lesions that have a more ominous clinical course. This case is being reported to stress that multiple or eruptive "vascular" lesions do not always reflect an underlying immunosuppression or malignancy.

Topics: Adipose Tissue; Adult; Angiolipoma; Diagnosis, Differential; Fibrin; Humans; Male; Skin Neoplasms; Thrombosis