Page last updated: 2024-08-23

fialuridine and Hepatitis B

fialuridine has been researched along with Hepatitis B in 19 studies

Research

Studies (19)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	19 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Conjeevaram, H; Di Bisceglie, AM; Fried, MW; Kleiner, D; Luciano, C; McKenzie, R; Park, Y; Sallie, R; Savarese, B; Tsokos, M	1
Swartz, MN	1
de Man, RA; Heijtink, RA; Niesters, HG; Schalm, SW	2
Caldwell, SH; Dickson, RC; Ishitani, MB; McGory, RW; Oliveira, WM; Pruett, TL; Stevenson, WC	1
Caldwell, S; Dickson, R; Gaffey, M; Ishitani, M; Lobo, P; McCullough, C; Pruett, T; Stevenson, W	1
Brahams, D	1
Marwick, C	1
Marshall, E	1
Macilwain, C	1
Bari, A	1
Lewis, W; Perrino, FW	1
Gordon, M	1
Colacino, JM	1
Ascenzi, MA; de Courten-Myers, G; Engelman, L; Gerin, JL; Griniuviene, B; Hornbuckle, WE; Levine, ES; Lewis, W; Montione, R; Tankersley, KO; Tennant, BC	1
Gaffey, MJ; Hoofnagle, JH; Kleiner, DE; McKenzie, R; Nichols, L; Sallie, R; Straus, SE; Tsokos, M	1
de Man, RA; Honkoop, P; Schalm, SW; Scholte, HR	1
Ascenzi, MA; Baldwin, BH; Bowsher, RR; Colacino, JM; Cote, PJ; Engelhardt, JA; Erb, HN; Gerin, JL; Graham, LA; Hornbuckle, WE; Korba, BE; Lewis, W; Lopez, C; Richardson, FC; Rowland, PH; Tennant, BC; Tochkov, IA; Yeager, AE	1
Miller, JP; Mintz, PD	1

Reviews

4 review(s) available for fialuridine and Hepatitis B

Article	Year
New nucleoside analogues for chronic hepatitis B. Journal of hepatology, 1995, Volume: 22, Issue:1 Suppl Topics: 2-Aminopurine; Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; Drug Evaluation, Preclinical; Famciclovir; Hepatitis B; Humans; Lamivudine; Nucleosides; Zalcitabine	1995
New developments in antiviral therapy for chronic hepatitis B infection. Scandinavian journal of gastroenterology. Supplement, 1995, Volume: 212 Topics: 2-Aminopurine; Antiviral Agents; Arabinofuranosyluracil; Clinical Trials as Topic; Famciclovir; Hepatitis B; Hepatitis, Chronic; Humans; Interferon-alpha; Lamivudine; Treatment Outcome; Zalcitabine	1995
Mechanisms for the anti-hepatitis B virus activity and mitochondrial toxicity of fialuridine (FIAU). Antiviral research, 1996, Volume: 29, Issue:2-3 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; DNA, Mitochondrial; Electron Transport Complex IV; Hepatitis B; Hepatitis B virus; Humans; Liver	1996
Mitochondrial injury. Lessons from the fialuridine trial. Drug safety, 1997, Volume: 17, Issue:1 Topics: Antiviral Agents; Arabinofuranosyluracil; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; DNA-Directed DNA Polymerase; Hepatitis B; Hepatitis B virus; Humans; Liver; Mitochondria; Oxidation-Reduction; Pyruvates; Risk Assessment; Structure-Activity Relationship	1997

Trials

2 trial(s) available for fialuridine and Hepatitis B

Article	Year
Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B. The New England journal of medicine, 1995, Oct-26, Volume: 333, Issue:17 Topics: Acidosis, Lactic; Adult; Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; DNA, Mitochondrial; DNA, Viral; Drugs, Investigational; Female; Hepatitis B; Humans; Jaundice; Liver; Liver Failure; Liver Transplantation; Male; Middle Aged; Pancreatitis; Peripheral Nervous System Diseases	1995
Deaths in US fialuridine trial. Lancet (London, England), 1994, Jun-11, Volume: 343, Issue:8911 Topics: Acidosis, Lactic; Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Arabinofuranosyluracil; Cause of Death; Chronic Disease; Female; Hepatitis B; Humans; Male; Middle Aged; Survival Rate	1994

Article

Year

Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

The New England journal of medicine, 1995, Oct-26, Volume: 333, Issue:17

Topics: Acidosis, Lactic; Adult; Alanine Transaminase; Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; DNA, Mitochondrial; DNA, Viral; Drugs, Investigational; Female; Hepatitis B; Humans; Jaundice; Liver; Liver Failure; Liver Transplantation; Male; Middle Aged; Pancreatitis; Peripheral Nervous System Diseases

1995

Deaths in US fialuridine trial.

Lancet (London, England), 1994, Jun-11, Volume: 343, Issue:8911

Topics: Acidosis, Lactic; Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Arabinofuranosyluracil; Cause of Death; Chronic Disease; Female; Hepatitis B; Humans; Male; Middle Aged; Survival Rate

1994

Other Studies

13 other study(ies) available for fialuridine and Hepatitis B

Article	Year
Mitochondrial toxicity--new adverse drug effects. The New England journal of medicine, 1995, Oct-26, Volume: 333, Issue:17 Topics: Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; Clinical Trials as Topic; DNA, Mitochondrial; Hepatitis B; Humans; Liver Failure	1995
Effects of fialuridine on hepatitis B immune globulin pharmacokinetics following orthotopic liver transplant for chronic hepatitis B viral-induced cirrhosis. Transplantation proceedings, 1995, Volume: 27, Issue:1 Topics: Adult; Antiviral Agents; Arabinofuranosyluracil; DNA, Viral; Female; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins, Intravenous; Liver Cirrhosis; Liver Transplantation; Male	1995
Clinical course of four patients receiving the experimental antiviral agent fialuridine for the treatment of chronic hepatitis B infection. Transplantation proceedings, 1995, Volume: 27, Issue:1 Topics: Antiviral Agents; Arabinofuranosyluracil; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Hepatitis B; Humans; Lactates; Liver Transplantation; Randomized Controlled Trials as Topic	1995
NIH panel report of 'no flaws' in FIAU trial at variance with FDA report, new probe planned. JAMA, 1994, Jul-06, Volume: 272, Issue:1 Topics: Antiviral Agents; Arabinofuranosyluracil; Cause of Death; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Hepatitis B; Hepatitis, Chronic; Humans; Liver Diseases; National Institutes of Health (U.S.); Scientific Misconduct; United States; United States Food and Drug Administration	1994
Hepatitis study. Drug trial deaths deemed unavoidable. Science (New York, N.Y.), 1994, Jun-10, Volume: 264, Issue:5165 Topics: Antiviral Agents; Arabinofuranosyluracil; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Federal Government; Government Regulation; Hepatitis B; Humans; National Institutes of Health (U.S.); Pancreatic Diseases; Research Subjects; United States; United States Food and Drug Administration	1994
NIH, FDA seek lessons from hepatitis B drug trial deaths. Nature, 1993, Jul-22, Volume: 364, Issue:6435 Topics: Antiviral Agents; Arabinofuranosyluracil; Hepatitis B; Humans; National Institutes of Health (U.S.); United States; United States Food and Drug Administration	1993
Severe toxicity of fialuridine (FIAU) The New England journal of medicine, 1996, Apr-25, Volume: 334, Issue:17 Topics: Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; Hepatitis B; Humans; Interferons; Nucleosides	1996
Severe toxicity of fialuridine (FIAU) The New England journal of medicine, 1996, Apr-25, Volume: 334, Issue:17 Topics: Antiviral Agents; Arabinofuranosyluracil; DNA Polymerase III; DNA, Mitochondrial; Drug Evaluation, Preclinical; Hepatitis B; Humans; In Vitro Techniques	1996
Severe toxicity of fialuridine (FIAU) The New England journal of medicine, 1996, Apr-25, Volume: 334, Issue:17 Topics: Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; Cytarabine; Drug Approval; Hepatitis B; Humans	1996
Depletion of mitochondrial DNA, destruction of mitochondria, and accumulation of lipid droplets result from fialuridine treatment in woodchucks (Marmota monax). Laboratory investigation; a journal of technical methods and pathology, 1997, Volume: 76, Issue:1 Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; DNA Damage; DNA, Mitochondrial; Heart; Hepatitis B; Hepatitis B Virus, Woodchuck; Kidney; Lipids; Liver; Marmota; Mitochondria; Mitochondria, Muscle; Muscle, Skeletal; Myocardium	1997
Histopathologic changes associated with fialuridine hepatotoxicity. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 1997, Volume: 10, Issue:3 Topics: Adult; Antiviral Agents; Arabinofuranosyluracil; Chemical and Drug Induced Liver Injury; Chronic Disease; Clinical Trials, Phase II as Topic; Female; Hepatitis B; Humans; Liver; Male; Middle Aged; Randomized Controlled Trials as Topic	1997
Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection. Hepatology (Baltimore, Md.), 1998, Volume: 28, Issue:1 Topics: Animals; Anorexia; Antiviral Agents; Arabinofuranosyluracil; Carrier State; DNA, Viral; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B virus; Liver; Marmota; Muscles; Sleep Stages; Time Factors; Virus Replication	1998
Falsely low calcium measurements after high volume plasma exchange in a patient with liver failure. Transfusion science, 1994, Volume: 15, Issue:3 Topics: Acidosis, Lactic; Anticoagulants; Antiviral Agents; Arabinofuranosyluracil; Calcium; Citrates; Citric Acid; Hepatitis B; Hepatorenal Syndrome; Humans; Liver Failure; Liver Transplantation; Male; Middle Aged; Plasma Exchange; Predictive Value of Tests; Spectrophotometry, Atomic	1994