fg 7142 has been researched along with Substance Withdrawal Syndrome in 14 studies
FG 7142: benzodiazepine receptor agonist
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of the calcium channel blocking agent, nitrendipine, were studied on seizures in mice produced during withdrawal from chronic benzodiazepine treatment and on the development of tolerance to benzodiazepines." | 7.68 | Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs. ( Bowhay, AR; Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Siarey, RJ, 1990) |
| "Benzodiazepine withdrawal, spontaneous or precipitated by the receptor antagonist, flumazenil, produces anxiety that can be measured in animal models." | 4.78 | The benzodiazepines: anxiolytic and withdrawal effects. ( Little, HJ, 1991) |
| " Acute nitrendipine significantly increased the latency of seizures in response to the partial benzodiazepine inverse agonist FG7142 during barbiturate withdrawal, but there was no effect on the seizure incidence in response to bicuculline." | 3.69 | Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal. ( Brown, J; Butterworth, AR; Little, HJ; Rabbani, M, 1994) |
| " The effects of the calcium channel blocking agent, nitrendipine, were studied on seizures in mice produced during withdrawal from chronic benzodiazepine treatment and on the development of tolerance to benzodiazepines." | 3.68 | Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs. ( Bowhay, AR; Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Siarey, RJ, 1990) |
| "3." | 1.28 | Lorazepam discontinuation promotes 'inverse agonist' effects of benzodiazepines. ( Greenblatt, DJ; Lopez, F; Miller, LG; Schatzki, A; Shader, RI, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| López Patiño, MA | 1 |
| Yu, L | 1 |
| Yamamoto, BK | 1 |
| Zhdanova, IV | 1 |
| Laurie, DJ | 1 |
| Pratt, JA | 1 |
| Rabbani, M | 2 |
| Brown, J | 1 |
| Butterworth, AR | 1 |
| Little, HJ | 3 |
| Vigorito, M | 1 |
| Lau, CE | 1 |
| Tang, M | 1 |
| Falk, JL | 1 |
| Sannerud, CA | 1 |
| Allen, M | 1 |
| Cook, JM | 1 |
| Griffiths, RR | 1 |
| Dolin, SJ | 1 |
| Patch, TL | 1 |
| Siarey, RJ | 1 |
| Bowhay, AR | 1 |
| Giorgi, O | 2 |
| Corda, MG | 2 |
| Fernandez, A | 2 |
| Biggio, G | 2 |
| Schatzki, A | 1 |
| Lopez, F | 1 |
| Greenblatt, DJ | 1 |
| Shader, RI | 1 |
| Miller, LG | 1 |
| Dorow, R | 1 |
| Duka, T | 1 |
| Ongini, E | 1 |
| Marzanatti, M | 1 |
| Bamonte, F | 1 |
| Monopoli, A | 1 |
| Guzzon, V | 1 |
| Ida, Y | 1 |
| Roth, RH | 1 |
| File, SE | 1 |
| Pellow, S | 1 |
1 review available for fg 7142 and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
The benzodiazepines: anxiolytic and withdrawal effects.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Diazepam; Disease Models, Animal; Ethanol; Flumaz | 1991 |
13 other studies available for fg 7142 and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Gender differences in zebrafish responses to cocaine withdrawal.
Topics: Animals; Behavior, Animal; Brain; Carbolines; Chromatography, High Pressure Liquid; Cocaine; Dopamin | 2008 |
Flumazenil induces localised increases in glucose utilization during diazepam withdrawal in rats.
Topics: Animals; Autoradiography; Brain Chemistry; Carbolines; Densitometry; Deoxyglucose; Diazepam; Flumaze | 1993 |
Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal.
Topics: Anesthesia, General; Animals; Ataxia; Barbiturates; Bicuculline; Calcium Channels; Carbolines; Dihyd | 1994 |
Midazolam withdrawal and discriminative motor control: effects of FG 7142 and Ro 15-1788.
Topics: Animals; Brain Chemistry; Carbolines; Discrimination, Psychological; Dose-Response Relationship, Dru | 1991 |
Behavioral effects of benzodiazepine ligands in non-dependent, diazepam-dependent and diazepam-withdrawn baboons.
Topics: Animals; Behavior, Animal; Benzodiazepines; Carbolines; Diazepam; Dose-Response Relationship, Drug; | 1991 |
Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs.
Topics: Animals; Benzodiazepines; Calcium Channels; Carbolines; Drug Tolerance; Flurazepam; Male; Mice; Nitr | 1990 |
The beta-carboline derivatives ZK 93426 and FG 7142 fail to precipitate abstinence signs in diazepam-dependent cats.
Topics: Animals; Carbolines; Cats; Diazepam; Female; Male; Receptors, GABA-A; Substance Withdrawal Syndrome | 1989 |
Lorazepam discontinuation promotes 'inverse agonist' effects of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain Chemistry; Carbolines; Lorazepam; Male; Mice; S | 1989 |
The abstinence syndrome in diazepam-dependent cats is precipitated by Ro 15-1788 and Ro 15-4513 but not by the benzodiazepine receptor antagonist ZK 93426.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Cats; Diazepam; Flumazenil; Receptors, GABA-A; Substan | 1988 |
Anxiety: its generation by drugs and by their withdrawal.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Carbolines; Humans; Norepinephrine; Receptor | 1986 |
A beta-carboline antagonizes benzodiazepine actions but does not precipitate the abstinence syndrome in cats.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Brain; Carbolines; Cats; Diazepam; Electroencephalogra | 1985 |
The activation of mesoprefrontal dopamine neurons by FG 7142 is absent in rats treated chronically with diazepam.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Appetite Depressants; Carbolines; Cerebral Cortex; Diazepam | 1987 |
Chlordiazepoxide enhances the anxiogenic action of CGS 8216 in the social interaction test: evidence for benzodiazepine withdrawal?
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Chlordiazepoxide; Flumazenil; Humans; Male; Pyrazol | 1985 |