fg 7142 has been researched along with Seizures in 34 studies
FG 7142: benzodiazepine receptor agonist
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 7.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| " The effects of the calcium channel blocking agent, nitrendipine, were studied on seizures in mice produced during withdrawal from chronic benzodiazepine treatment and on the development of tolerance to benzodiazepines." | 7.68 | Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs. ( Bowhay, AR; Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Siarey, RJ, 1990) |
| "The brain regions that may be functionally involved in the control of anxiety and the development of seizures were examined using quantitative 1-14C-deoxyglucose autoradiography." | 7.67 | Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity. ( Ableitner, A; Herz, A, 1987) |
| "In animals not expressing convulsions, FG 7142 (1-10 mg/kg) effected increases in glucose utilization in 33 of the 65 regions examined." | 5.27 | The effects of FG 7142 upon local cerebral glucose utilization suggest overlap between limbic structures important in anxiety and convulsions. ( Laurie, DJ; McCulloch, J; Pratt, JA, 1988) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 3.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| " Acute nitrendipine significantly increased the latency of seizures in response to the partial benzodiazepine inverse agonist FG7142 during barbiturate withdrawal, but there was no effect on the seizure incidence in response to bicuculline." | 3.69 | Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal. ( Brown, J; Butterworth, AR; Little, HJ; Rabbani, M, 1994) |
| " In vivo, NNC-711 was a potent anticonvulsant compound against rodent seizures induced by methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) (ED50 (clonic) = 1." | 3.68 | NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization. ( Andersen, KE; Frederiksen, K; Knutsen, LJ; Nielsen, EB; Suzdak, PD; Sørensen, PO, 1992) |
| " The effects of continuous administration of FG 7142 on GABA-stimulated uptake of 36Cl-, the threshold for bicuculline-induced seizures and the proconvulsant actions of acute administration FG 7142 were evaluated." | 3.68 | Chronic administration of beta-carboline-3-carboxylic acid methylamide by continuous intraventricular infusion increases GABAergic function. ( Gallager, DW; Heninger, C; Hernandez, TD; Marley, RJ, 1991) |
| " The effects of the calcium channel blocking agent, nitrendipine, were studied on seizures in mice produced during withdrawal from chronic benzodiazepine treatment and on the development of tolerance to benzodiazepines." | 3.68 | Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs. ( Bowhay, AR; Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Siarey, RJ, 1990) |
| "The mechanism of action of aminophylline in prolonging seizures was tested in amygdala-kindled rats." | 3.68 | Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline. ( Dragunow, M, 1990) |
| "Repeated administration of the beta-carboline FG 7142 results in sensitisation to its convulsant effects (chemical kindling); acutely FG 7142 is not convulsant, but following several treatments full seizures develop." | 3.67 | Blockade of FG 7142 kindling by anticonvulsants acting at sites distant from the benzodiazepine receptor. ( Stephens, DN; Weidmann, R, 1989) |
| "Repeated administration of the beta-carboline benzodiazepine receptor ligand FG 7142 produces sensitization to its effects so that full seizures develop (chemical kindling); initially it is only pro-convulsant." | 3.67 | The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142. ( Little, HJ; Nutt, DJ; Taylor, SC, 1986) |
| " A significant sensitization to seizures induced by isoniazid, a drug known to inhibit GABAergic transmission, was also found to occur after long-term (25 days) withdrawal." | 3.67 | Behavioural and biochemical evidence for a long-lasting decrease in GABAergic function elicited by chronic administration of FG 7142. ( Biggio, G; Corda, MG; Giorgi, O, 1986) |
| "The brain regions that may be functionally involved in the control of anxiety and the development of seizures were examined using quantitative 1-14C-deoxyglucose autoradiography." | 3.67 | Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity. ( Ableitner, A; Herz, A, 1987) |
| "GABA is crucial in the generation of absence seizures." | 1.31 | Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy. ( Boehrer, A; Marescaux, C; Reibel, S; Simler, S; Vergnes, M, 2000) |
| "Chemically kindled clonic seizures were observed in 100% of TMPP or FG-7142 and 50% of PTZ treated rats by the thirtieth dosing." | 1.30 | Repeated exposure to trimethylolpropane phosphate induces central nervous system sensitization and facilitates electrical kindling. ( Cassell, J; Lin, J; Nordholm, AF; Ritchie, GD; Rossi, J, 1998) |
| " Chronic administration of the benzodiazepine inverse agonist FG 7142 has previously been shown to induce seizure activity in mice." | 1.28 | Acetylcholinesterase activity in regions of mouse brain following acute and chronic treatment with a benzodiazepine inverse agonist. ( Appleyard, ME; Little, HJ; Taylor, SC, 1990) |
| "Pentylenetetrazol (PTZ)-induced convulsion were studied in control, chronic ethanol-maintained, and ethanol-withdrawal rats." | 1.28 | Chronic ethanol treatment alters the behavioral effects of Ro 15-4513, a partially negative ligand for benzodiazepine binding sites. ( Mehta, AK; Ticku, MK, 1989) |
| "3." | 1.28 | Lorazepam discontinuation promotes 'inverse agonist' effects of benzodiazepines. ( Greenblatt, DJ; Lopez, F; Miller, LG; Schatzki, A; Shader, RI, 1989) |
| "A method for measuring seizure thresholds using an intravenous infusion of a convulsant beta-carboline benzodiazepine receptor ligand (DMCM) is reported." | 1.27 | Investigating benzodiazepine receptor function in vivo using an intravenous infusion of DMCM. ( Little, HJ; Minchin, MC; Nutt, DJ; Taylor, SC, 1984) |
| "Thus, myoclonic seizures were observed in 30% and 80% of the animals by the third and the eighth day of treatment, respectively." | 1.27 | Enhanced sensitivity to beta-carboline inverse agonists in rats chronically treated with FG 7142. ( Biggio, G; Corda, MG; Giorgi, O; Mele, S, 1987) |
| "Lorazepam pretreated mice showed a significantly lower sensitivity to the anticonvulsant effects of the benzodiazepine (BZ) receptor ligands lorazepam, ZK 93423, ZK 91296, Ro 15-1788 and ZK 93426 administered acutely by the IP route when challenged with DMCM 24 hr after the last dose of lorazepam." | 1.27 | Lorazepam and FG 7142 induce tolerance to the DMCM antagonistic effect of benzodiazepine receptor ligands. ( Jensen, LH; Petersen, EN, 1987) |
| " In neither case were the pharmacological changes induced by chronic administration reflected by changes in the biochemical measures of the coupling between benzodiazepine binding sites and gamma-aminobutyric acid (GABA) receptors." | 1.27 | Co-existence of kindling induced by the beta-carboline, FG 7142, and tolerance to diazepam following chronic treatment in mice. ( Schneider, HH; Stephens, DN, 1988) |
| "In animals not expressing convulsions, FG 7142 (1-10 mg/kg) effected increases in glucose utilization in 33 of the 65 regions examined." | 1.27 | The effects of FG 7142 upon local cerebral glucose utilization suggest overlap between limbic structures important in anxiety and convulsions. ( Laurie, DJ; McCulloch, J; Pratt, JA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (61.76) | 18.7374 |
| 1990's | 12 (35.29) | 18.2507 |
| 2000's | 1 (2.94) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nutt, DJ | 5 |
| Little, HJ | 6 |
| Taylor, SC | 4 |
| Minchin, MC | 1 |
| Nutt, D | 1 |
| Rabbani, M | 2 |
| Brown, J | 1 |
| Butterworth, AR | 1 |
| Mizoguchi, H | 1 |
| Yoshiike, M | 1 |
| Suzuki, T | 1 |
| Misawa, M | 1 |
| Klitgaard, H | 1 |
| Matagne, A | 1 |
| Gobert, J | 1 |
| Wülfert, E | 1 |
| Lin, J | 1 |
| Cassell, J | 1 |
| Ritchie, GD | 1 |
| Rossi, J | 1 |
| Nordholm, AF | 1 |
| Vergnes, M | 1 |
| Boehrer, A | 1 |
| Reibel, S | 1 |
| Simler, S | 1 |
| Marescaux, C | 1 |
| Suzdak, PD | 1 |
| Frederiksen, K | 1 |
| Andersen, KE | 1 |
| Sørensen, PO | 1 |
| Knutsen, LJ | 1 |
| Nielsen, EB | 1 |
| Marley, RJ | 1 |
| Heninger, C | 1 |
| Hernandez, TD | 1 |
| Gallager, DW | 1 |
| Corda, MG | 5 |
| Orlandi, M | 1 |
| Lecca, D | 1 |
| Carboni, G | 1 |
| Frau, V | 1 |
| Giorgi, O | 5 |
| Appleyard, ME | 1 |
| Dolin, SJ | 1 |
| Patch, TL | 1 |
| Siarey, RJ | 1 |
| Bowhay, AR | 1 |
| Deutsch, SI | 1 |
| Rosse, RB | 1 |
| Huntzinger, JA | 1 |
| Novitzki, MR | 1 |
| Mastropaolo, J | 1 |
| Dragunow, M | 1 |
| Piot, O | 1 |
| Betschart, J | 1 |
| Stutzmann, JM | 1 |
| Blanchard, JC | 1 |
| Longoni, B | 2 |
| Fernandez, A | 1 |
| Biggio, G | 4 |
| Mehta, AK | 1 |
| Ticku, MK | 2 |
| Stephens, DN | 2 |
| Weidmann, R | 1 |
| Schatzki, A | 1 |
| Lopez, F | 1 |
| Greenblatt, DJ | 1 |
| Shader, RI | 1 |
| Miller, LG | 1 |
| Kulkarni, SK | 1 |
| Mele, S | 1 |
| Petersen, EN | 1 |
| Jensen, LH | 1 |
| Trullas, R | 1 |
| Ginter, H | 1 |
| Jackson, B | 1 |
| Skolnick, P | 1 |
| Allen, MS | 1 |
| Hagen, TJ | 1 |
| Cook, JM | 1 |
| Schneider, HH | 1 |
| Lister, RG | 1 |
| Massotti, M | 1 |
| Lucantoni, D | 1 |
| Caporali, MG | 1 |
| Mele, L | 1 |
| Gatta, F | 1 |
| Beck, CH | 1 |
| Cooper, SJ | 1 |
| Ableitner, A | 1 |
| Herz, A | 1 |
| Costello, MJ | 1 |
| Pratt, JA | 1 |
| Laurie, DJ | 1 |
| McCulloch, J | 1 |
34 other studies available for fg 7142 and Seizures
| Article | Year |
|---|---|
Investigating benzodiazepine receptor function in vivo using an intravenous infusion of DMCM.
Topics: Animals; Anticonvulsants; Carbolines; Convulsants; Drug Interactions; Electroshock; Indoles; Infusio | 1984 |
Pharmacological and behavioural studies of benzodiazepine antagonists and contragonists.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepinones; Carbolines; Conditioning, Operant | 1983 |
Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal.
Topics: Anesthesia, General; Animals; Ataxia; Barbiturates; Bicuculline; Calcium Channels; Carbolines; Dihyd | 1994 |
Effects of Ca2+ channel blockers on physical dependence on diazepam in mice.
Topics: Animals; Brain; Calcium Channel Blockers; Carbolines; Diazepam; Diltiazem; Drug Interactions; Flunar | 1993 |
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Mod | 1998 |
Repeated exposure to trimethylolpropane phosphate induces central nervous system sensitization and facilitates electrical kindling.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Central Nervous System; Convulsants; E | 1998 |
Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy.
Topics: 3-Mercaptopropionic Acid; Animals; Bicuculline; Carbolines; Convulsants; Electroencephalography; Epi | 2000 |
NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization.
Topics: Animals; Anticonvulsants; Astrocytes; Behavior, Animal; Brain; Carbolines; Cells, Cultured; Convulsa | 1992 |
Chronic administration of beta-carboline-3-carboxylic acid methylamide by continuous intraventricular infusion increases GABAergic function.
Topics: Animals; Bicuculline; Carbolines; Cerebral Cortex; Cerebral Ventricles; Chlorine; Dose-Response Rela | 1991 |
Pentylenetetrazol-induced kindling in rats: effect of GABA function inhibitors.
Topics: Animals; Azides; Benzodiazepines; Carbolines; GABA Antagonists; Isoniazid; Kindling, Neurologic; Mal | 1991 |
Acetylcholinesterase activity in regions of mouse brain following acute and chronic treatment with a benzodiazepine inverse agonist.
Topics: Acetylcholinesterase; Animals; Brain; Carbolines; Kindling, Neurologic; Male; Mice; Receptors, GABA- | 1990 |
Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs.
Topics: Animals; Benzodiazepines; Calcium Channels; Carbolines; Drug Tolerance; Flurazepam; Male; Mice; Nitr | 1990 |
Profound stress-induced alterations in flurazepam's antiseizure efficacy can be attenuated.
Topics: Animals; Carbolines; Clonazepam; Cold Temperature; Diazepam; Dose-Response Relationship, Drug; Elect | 1990 |
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline.
Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neur | 1990 |
Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
Topics: Animals; Azabicyclo Compounds; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Flunitraze | 1990 |
Increased sensitivity to inverse agonists and decreased GABA-stimulated chloride influx induced by chronic treatment with FG 7142.
Topics: Animals; Anti-Anxiety Agents; Appetite Depressants; Benzodiazepines; Carbolines; Chlorides; gamma-Am | 1988 |
Chronic ethanol treatment alters the behavioral effects of Ro 15-4513, a partially negative ligand for benzodiazepine binding sites.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Convulsants; Drug Interactions; Ethanol; Male; Pentyle | 1989 |
Blockade of FG 7142 kindling by anticonvulsants acting at sites distant from the benzodiazepine receptor.
Topics: Animals; Anticonvulsants; Carbolines; Clonazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Female; | 1989 |
Lorazepam discontinuation promotes 'inverse agonist' effects of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain Chemistry; Carbolines; Lorazepam; Male; Mice; S | 1989 |
RO15-4513 but not FG-7142 reverses anticonvulsant effects of ethanol against bicuculline- and picrotoxin-induced convulsions in rats.
Topics: Affinity Labels; Animals; Appetite Depressants; Azides; Benzodiazepines; Bicuculline; Carbolines; Et | 1989 |
Enhanced sensitivity to beta-carboline inverse agonists in rats chronically treated with FG 7142.
Topics: Animals; Brain; Carbolines; Convulsants; Drug Tolerance; gamma-Aminobutyric Acid; Male; Rats; Rats, | 1987 |
Lorazepam and FG 7142 induce tolerance to the DMCM antagonistic effect of benzodiazepine receptor ligands.
Topics: Animals; Carbolines; Dose-Response Relationship, Drug; Drug Tolerance; Female; Lorazepam; Male; Mice | 1987 |
Decreased sensitivity to diazepam induced by chronic administration of FG 7142.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Brain; Brain Chemistry; Carbolines; Convulsants; | 1988 |
3-Ethoxy-beta-carboline: a high affinity benzodiazepine receptor ligand with partial inverse agonist properties.
Topics: Animals; Binding, Competitive; Brain; Carbolines; Cerebellum; Cerebral Cortex; Convulsants; Drug Syn | 1988 |
Co-existence of kindling induced by the beta-carboline, FG 7142, and tolerance to diazepam following chronic treatment in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Carbolines; Diazepam; Drug Tolerance; Female; Kindlin | 1988 |
Antagonizing the anticonvulsant effect of ethanol using drugs acting at the benzodiazepine/GABA receptor complex.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Benzodiazepinones; Carbolines; Convulsants; Dose- | 1988 |
Supraspinal convulsions induced by inverse benzodiazepine agonists in rabbits.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Electroencephalography; Flumazenil; Male; Pyrazole | 1985 |
The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142.
Topics: Animals; Bicuculline; Body Temperature; Carbolines; gamma-Aminobutyric Acid; Kindling, Neurologic; M | 1986 |
Behavioural and biochemical evidence for a long-lasting decrease in GABAergic function elicited by chronic administration of FG 7142.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Carbolines; Cerebellum; Cerebral Cor | 1986 |
Selective changes in the in vivo effects of benzodiazepine receptor ligands after chemical kindling with FG 7142.
Topics: Animals; Benzodiazepines; Body Temperature; Carbolines; Flurazepam; Kindling, Neurologic; Mice; Pyra | 1987 |
The effect of the beta-carboline FG 7142 on the behaviour of male rats in a living cage: an ethological analysis of social and nonsocial behaviour.
Topics: Aggression; Animals; Behavior, Animal; Carbolines; Grooming; Interpersonal Relations; Male; Motor Ac | 1986 |
Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity.
Topics: Animals; Anxiety; Autoradiography; Brain; Carbolines; Convulsants; Deoxyglucose; Flumazenil; Glucose | 1987 |
Rapid induction of lorazepam dependence and reversal with flumazenil.
Topics: Animals; Carbolines; Flumazenil; Lorazepam; Male; Mice; Mice, Inbred Strains; Seizures; Substance-Re | 1988 |
The effects of FG 7142 upon local cerebral glucose utilization suggest overlap between limbic structures important in anxiety and convulsions.
Topics: Animals; Anxiety; Brain; Carbolines; Deoxy Sugars; Deoxyglucose; Dose-Response Relationship, Drug; L | 1988 |