fg 7142 has been researched along with Anxiety in 119 studies
FG 7142: benzodiazepine receptor agonist
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe the first human experience with FG 7142, a drug which in a phase I study has caused severe anxiety attacks and which therefore could be a validated tool for further experimental studies of anxiety." | 9.34 | FG 7142: is this validated tool to study anxiety now forgotten? ( Horowski, R, 2020) |
| " The compounds chosen are likely to produce anxiety by activity at different sites in the central nervous system: yohimbine, by blocking the alpha 2-adrenoceptor; FG 7142, by action at the beta-carboline site on the GABA-benzodiazepine receptor complex and pentylenetetrazole, by acting at the picrotoxinin site on this complex." | 7.67 | Chronic treatment with imipramine does not reverse the effects of 3 anxiogenic compounds in a test of anxiety in the rat. ( File, SE; Johnston, AL, 1987) |
| "The brain regions that may be functionally involved in the control of anxiety and the development of seizures were examined using quantitative 1-14C-deoxyglucose autoradiography." | 7.67 | Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity. ( Ableitner, A; Herz, A, 1987) |
| "The behavioural effects of the beta-carboline FG 7142 were investigated in the social interaction test of anxiety and the holeboard test of exploration and locomotor activity." | 7.67 | Effects of the beta-carboline, FG 7142, in the social interaction test of anxiety and the holeboard: correlations between behaviour and plasma concentrations. ( Braestrup, C; File, SE; Pellow, S, 1985) |
| "In animals not expressing convulsions, FG 7142 (1-10 mg/kg) effected increases in glucose utilization in 33 of the 65 regions examined." | 5.27 | The effects of FG 7142 upon local cerebral glucose utilization suggest overlap between limbic structures important in anxiety and convulsions. ( Laurie, DJ; McCulloch, J; Pratt, JA, 1988) |
| "Benzodiazepine withdrawal, spontaneous or precipitated by the receptor antagonist, flumazenil, produces anxiety that can be measured in animal models." | 4.78 | The benzodiazepines: anxiolytic and withdrawal effects. ( Little, HJ, 1991) |
| " Here, we tested the ability of the benzodiazepine (BZ) inverse agonist, FG 7142, to elicit anxiety-like behavior and potentiate stress responses in rats as measured by standard behavioral and hormonal indices and for its ability to affect reinstatement of cocaine-seeking in rats with a prior history of cocaine self-administration." | 3.77 | Chronic cocaine self-administration attenuates the anxiogenic-like and stress potentiating effects of the benzodiazepine inverse agonist, FG 7142. ( See, RE; Waters, RP, 2011) |
| "We used Fos immunocytochemistry to test the effects of four anxiogenic drugs (FG-7142, yohimbine, m-chlorophenylpiperazine [mCPP], and caffeine) on anxiety-related circuitry in rat forebrain." | 3.72 | Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs. ( Salchner, P; Sharp, T; Singewald, N, 2003) |
| "The effects of acute administration of the anxiogenic benzodiazepine receptor ligand, N-methyl-beta-carboline-3-carboxamide (FG 7142) and of a single exposure to the elevated plus-maze test of anxiety on preprocholecystokinin mRNA levels in rat brain were examined using the technique of in situ hybridisation." | 3.69 | The benzodiazepine receptor inverse agonist FG 7142 induces cholecystokinin gene expression in rat brain. ( Brett, RR; Pratt, JA, 1995) |
| "The effects of the anxiogenic agents FG7142, caffeine, pentylenetetrazole, and amphetamine were assessed in two anxiety situations in the marmoset, first in an "anxiogenic" test based on the animal's response to a human observer standing in front of the home cage and second in a low-anxiety situation where animals behaviour was videotaped in the absence of the observer." | 3.68 | Behavioural effects of anxiogenic agents in the common marmoset. ( Carey, GJ; Costall, B; Domeney, AM; Jones, DN; Naylor, RJ, 1992) |
| " The compounds chosen are likely to produce anxiety by activity at different sites in the central nervous system: yohimbine, by blocking the alpha 2-adrenoceptor; FG 7142, by action at the beta-carboline site on the GABA-benzodiazepine receptor complex and pentylenetetrazole, by acting at the picrotoxinin site on this complex." | 3.67 | Chronic treatment with imipramine does not reverse the effects of 3 anxiogenic compounds in a test of anxiety in the rat. ( File, SE; Johnston, AL, 1987) |
| "The effects of FG 7142, CGS 8216 and Ro 15-1788, three compounds that are believed to produce anxiety by an action at benzodiazepine receptors in the CNS, are investigated on the plasma corticosterone concentrations in the rat both in the home cage and after exposure to novelty stress." | 3.67 | The effects of putative anxiogenic compounds (FG 7142, CGS 8216 and Ro 15-1788) on the rat corticosterone response. ( File, SE; Pellow, S, 1985) |
| "The brain regions that may be functionally involved in the control of anxiety and the development of seizures were examined using quantitative 1-14C-deoxyglucose autoradiography." | 3.67 | Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity. ( Ableitner, A; Herz, A, 1987) |
| "The effects of RO 15-4513, RO 15-3505 and FG 7142 on the anxiolytic properties of ethanol in mice were investigated using the plus-maze test of anxiety." | 3.67 | Interactions of three benzodiazepine receptor inverse agonists with ethanol in a plus-maze test of anxiety. ( Lister, RG, 1988) |
| "Post-traumatic stress disorder (PTSD) is an anxiety disorder that not only affects mental health, but may also affect bone health." | 1.38 | Lasting consequences of traumatic events on behavioral and skeletal parameters in a mouse model for post-traumatic stress disorder (PTSD). ( Johnson, PJ; Kesavan, C; Mohan, S; Watt, H; Wergedal, JE; Yu, H, 2012) |
| "Diazepam was anxiolytic in males but not females." | 1.37 | Anxiolytic and anxiogenic drug effects on male and female gerbils in the black-white box. ( Bradley, BF; Bridges, NJ; Brown, SL; Lea, RW; Starkey, NJ, 2011) |
| " Long-term administration with imipramine or mirtazapine (10 mg/kg, i." | 1.31 | Chronic treatment with imipramine or mirtazapine antagonizes stress- and FG7142-induced increase in cortical norepinephrine output in freely moving rats. ( Biggio, G; Dazzi, L; Ladu, S; Pira, L; Rivano, A; Spiga, F; Vacca, G, 2002) |
| " Long-term administration of venlafaxine (10 mg/kg i." | 1.31 | Inhibition by venlafaxine of the increase in norepinephrine output in rat prefrontal cortex elicited by acute stress or by the anxiogenic drug FG 7142. ( Biggio, G; Dazzi, L; Ladu, S; Seu, E; Vacca, G; Vignone, V, 2002) |
| "When FG 7142 (20 mg/kg) was administered during five consecutive days before behavioral testing, its anxiogenic-like effect first deepened, but waned off by the fifth session." | 1.30 | Characterization of rat exploratory behavior using the exploration box test. ( Allikmets, L; Harro, J; Matto, V; Otter, MH; Skrebuhhova, T; Sõukand, R, 1997) |
| "Flumazenil reversed the increase in defensiveness produced by FG-7142 in a drug-dependent manner as described in Adamec (1998a)." | 1.30 | Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior: study 3--the effects on amygdala efferent physiology of block of NMDA receptors p ( Adamec, RE, 1998) |
| " Three experiments showed that the OFDT: a) permitted dissociation between behavioral responses to an anxiolytic (diazepam) and an anxiogenic (FG7142) drug, b) detected a dose-response relationship for an anxiolytic drug (diazepam), and c) detected behavioral responses to environmental manipulations designed to increase fear (presence of an olfactory cue from rats that had received foot shock)." | 1.29 | An animal model for measuring behavioral responses to anxiogenic and anxiolytic manipulations. ( Stout, JC; Weiss, JM, 1994) |
| "In this study, the effect of the chronic administration of the benzodiazepine (BZD) receptor ligand FG 7142 on the rat conflict test was examined." | 1.27 | Long-lasting proconflict effect induced by chronic administration of the beta-carboline derivative FG 7142. ( Biggio, G; Corda, MG; Gatta, F; Giorgi, O, 1985) |
| "In animals not expressing convulsions, FG 7142 (1-10 mg/kg) effected increases in glucose utilization in 33 of the 65 regions examined." | 1.27 | The effects of FG 7142 upon local cerebral glucose utilization suggest overlap between limbic structures important in anxiety and convulsions. ( Laurie, DJ; McCulloch, J; Pratt, JA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (25.21) | 18.7374 |
| 1990's | 36 (30.25) | 18.2507 |
| 2000's | 29 (24.37) | 29.6817 |
| 2010's | 21 (17.65) | 24.3611 |
| 2020's | 3 (2.52) | 2.80 |
| Authors | Studies |
|---|---|
| Horowski, R | 3 |
| Matsuda, K | 3 |
| Yoshida, D | 1 |
| Watanabe, K | 2 |
| Yokobori, E | 1 |
| Konno, N | 3 |
| Nakamachi, T | 3 |
| Zewde, AM | 1 |
| Yu, F | 1 |
| Nayak, S | 1 |
| Tallarida, C | 1 |
| Reitz, AB | 1 |
| Kirby, LG | 2 |
| Rawls, SM | 1 |
| Panayotis, N | 2 |
| Sheinin, A | 1 |
| Dagan, SY | 2 |
| Tsoory, MM | 2 |
| Rother, F | 1 |
| Vadhvani, M | 1 |
| Meshcheriakova, A | 1 |
| Koley, S | 1 |
| Marvaldi, L | 1 |
| Song, DA | 1 |
| Reuveny, E | 1 |
| Eickholt, BJ | 1 |
| Hartmann, E | 1 |
| Bader, M | 1 |
| Michaelevski, I | 1 |
| Fainzilber, M | 2 |
| Chowdhury, TG | 1 |
| Wallin-Miller, KG | 1 |
| Rear, AA | 1 |
| Park, J | 2 |
| Diaz, V | 1 |
| Simon, NW | 1 |
| Moghaddam, B | 3 |
| Arrant, AE | 1 |
| Schramm-Sapyta, NL | 1 |
| Kuhn, CM | 1 |
| Yeung, M | 1 |
| Lu, L | 1 |
| Hughes, AM | 1 |
| Treit, D | 1 |
| Dickson, CT | 1 |
| Shibata, H | 1 |
| Sakashita, A | 1 |
| Iinuma, N | 1 |
| Wada, K | 1 |
| Kato, Y | 1 |
| Gokan, H | 1 |
| Oh-Nishi, A | 1 |
| Suhara, T | 1 |
| Watanabe, S | 2 |
| Minamimoto, T | 1 |
| Zhang, C | 1 |
| Chua, BE | 1 |
| Yang, A | 1 |
| Shabanpoor, F | 1 |
| Hossain, MA | 1 |
| Wade, JD | 1 |
| Rosengren, KJ | 1 |
| Smith, CM | 1 |
| Gundlach, AL | 1 |
| Wood, J | 1 |
| Bondi, C | 1 |
| Del Arco, A | 1 |
| Yuan, X | 1 |
| Devine, DP | 2 |
| Casarrubea, M | 1 |
| Faulisi, F | 1 |
| Pensabene, M | 1 |
| Mendola, C | 1 |
| Dell'Utri, R | 1 |
| Cardaci, M | 1 |
| Santangelo, A | 1 |
| Crescimanno, G | 1 |
| Major, CA | 1 |
| Kelly, BJ | 1 |
| Novak, MA | 1 |
| Davenport, MD | 1 |
| Stonemetz, KM | 1 |
| Meyer, JS | 1 |
| Sink, KS | 1 |
| Segovia, KN | 1 |
| Sink, J | 1 |
| Randall, PA | 1 |
| Collins, LE | 1 |
| Correa, M | 1 |
| Markus, EJ | 1 |
| Vemuri, VK | 1 |
| Makriyannis, A | 1 |
| Salamone, JD | 2 |
| Bradley, BF | 1 |
| Bridges, NJ | 1 |
| Starkey, NJ | 1 |
| Brown, SL | 1 |
| Lea, RW | 1 |
| Freeman-Daniels, E | 1 |
| Beck, SG | 1 |
| Waters, RP | 1 |
| See, RE | 1 |
| Choy, KH | 1 |
| Yu, J | 1 |
| Hawkes, D | 1 |
| Mayorov, DN | 1 |
| Lukkes, JL | 1 |
| Engelman, GH | 1 |
| Zelin, NS | 1 |
| Hale, MW | 1 |
| Lowry, CA | 3 |
| Sciolino, NR | 1 |
| Dishman, RK | 1 |
| Holmes, PV | 2 |
| Zheng, Y | 1 |
| Cheung, I | 1 |
| Smith, PF | 1 |
| Yu, H | 1 |
| Watt, H | 1 |
| Kesavan, C | 1 |
| Johnson, PJ | 1 |
| Wergedal, JE | 1 |
| Mohan, S | 1 |
| Dorrow, R | 1 |
| Singewald, N | 3 |
| Salchner, P | 2 |
| Sharp, T | 2 |
| Chaki, S | 1 |
| Kawashima, N | 1 |
| Suzuki, Y | 1 |
| Shimazaki, T | 1 |
| Okuyama, S | 1 |
| Jelen, P | 1 |
| Soltysik, S | 1 |
| Zagrodzka, J | 1 |
| Sena, LM | 1 |
| Bueno, C | 1 |
| Pobbe, RL | 1 |
| Andrade, TG | 1 |
| Zangrossi, H | 3 |
| Viana, MB | 1 |
| Jaskiw, GE | 3 |
| Lipska, BK | 2 |
| Weinberger, DR | 3 |
| Kurumaji, A | 1 |
| Umino, A | 1 |
| Tanami, M | 1 |
| Ito, A | 1 |
| Asakawa, M | 1 |
| Nishikawa, T | 1 |
| Fernandez, F | 1 |
| Misilmeri, MA | 1 |
| Felger, JC | 1 |
| Carvalho-Netto, EF | 1 |
| Nunes-de-Souza, RL | 1 |
| Degroot, A | 1 |
| Nomikos, GG | 1 |
| Dos Santos, L | 1 |
| de Andrade, TG | 1 |
| Atack, JR | 1 |
| Hutson, PH | 1 |
| Collinson, N | 1 |
| Marshall, G | 1 |
| Bentley, G | 1 |
| Moyes, C | 1 |
| Cook, SM | 1 |
| Collins, I | 1 |
| Wafford, K | 1 |
| McKernan, RM | 1 |
| Dawson, GR | 1 |
| Thompson, BL | 1 |
| Rosen, JB | 1 |
| Greco, B | 1 |
| Carli, M | 1 |
| Sartori, SB | 1 |
| Sinner, C | 1 |
| Wigger, A | 1 |
| Frank, E | 1 |
| Landgraf, R | 1 |
| Evans, AK | 2 |
| Abrams, JK | 1 |
| Bouwknecht, JA | 1 |
| Knight, DM | 1 |
| Shekhar, A | 1 |
| Hackler, EA | 1 |
| Turner, GH | 1 |
| Gresch, PJ | 1 |
| Sengupta, S | 1 |
| Deutch, AY | 1 |
| Avison, MJ | 1 |
| Gore, JC | 1 |
| Sanders-Bush, E | 1 |
| Ago, Y | 1 |
| Takahashi, K | 1 |
| Nakamura, S | 1 |
| Hashimoto, H | 1 |
| Baba, A | 1 |
| Matsuda, T | 1 |
| Rossier, J | 1 |
| Dodd, R | 1 |
| Felblum, S | 1 |
| Valin, A | 1 |
| Prado de Carvalho, L | 1 |
| Potier, P | 1 |
| Naquet, R | 1 |
| Dorow, R | 3 |
| Paschelke, G | 2 |
| Amin, M | 1 |
| Crawley, JN | 2 |
| Skolnick, P | 2 |
| Paul, SM | 2 |
| Petersen, EN | 1 |
| Kehr, W | 1 |
| Nielsen, M | 1 |
| Braestrup, C | 2 |
| Corda, MG | 2 |
| Costa, E | 1 |
| Guidotti, A | 1 |
| File, SE | 12 |
| Pellow, S | 8 |
| Concas, A | 1 |
| Sanna, E | 1 |
| Cuccheddu, T | 1 |
| Mascia, MP | 1 |
| Santoro, G | 1 |
| Maciocco, E | 1 |
| Biggio, G | 5 |
| Pratt, JA | 2 |
| Brett, RR | 1 |
| Cruz, AP | 1 |
| Frei, F | 1 |
| Graeff, FG | 2 |
| Russo, AS | 1 |
| Guimarães, FS | 1 |
| De Aguiar, JC | 1 |
| Stout, JC | 1 |
| Weiss, JM | 1 |
| Meng, ID | 1 |
| Drugan, RC | 3 |
| Woodmansee, WW | 1 |
| Silbert, LH | 1 |
| Maier, SF | 3 |
| Short, KR | 1 |
| Cole, BJ | 2 |
| Hillmann, M | 1 |
| Seidelmann, D | 1 |
| Klewer, M | 1 |
| Jones, GH | 1 |
| Rodgers, RJ | 1 |
| Cole, JC | 1 |
| Aboualfa, K | 1 |
| Stephenson, LH | 1 |
| Karreman, M | 1 |
| Berntson, GG | 2 |
| Hart, S | 2 |
| Sarter, M | 2 |
| Reddy, DS | 1 |
| Kulkarni, SK | 1 |
| Otter, MH | 1 |
| Matto, V | 1 |
| Sõukand, R | 1 |
| Skrebuhhova, T | 1 |
| Allikmets, L | 1 |
| Harro, J | 1 |
| Mason, K | 1 |
| Heal, DJ | 1 |
| Stanford, SC | 1 |
| Takeda, H | 1 |
| Tsuji, M | 1 |
| Matsumiya, T | 1 |
| Adamec, RE | 5 |
| Dazzi, L | 3 |
| Spiga, F | 2 |
| Pira, L | 2 |
| Ladu, S | 3 |
| Vacca, G | 3 |
| Rivano, A | 2 |
| Jentsch, JD | 1 |
| Karoum, F | 1 |
| Jones, N | 1 |
| Duxon, MS | 1 |
| King, SM | 1 |
| Nishimura, Y | 1 |
| Yoshida, M | 1 |
| Vignone, V | 1 |
| Seu, E | 1 |
| Panlilio, LV | 1 |
| Weiss, SJ | 1 |
| Thomas, DA | 1 |
| Glowa, JR | 1 |
| Sulcová, A | 2 |
| Krsiak, M | 1 |
| Donát, P | 1 |
| McCullough, LD | 1 |
| Carey, GJ | 1 |
| Costall, B | 1 |
| Domeney, AM | 1 |
| Jones, DN | 1 |
| Naylor, RJ | 1 |
| Bruhwyler, J | 1 |
| Chleide, E | 1 |
| Houbeau, G | 1 |
| Mercier, M | 1 |
| Fernández-Teruel, A | 1 |
| Escorihuela, RM | 1 |
| Núñez, JF | 1 |
| Zapata, A | 1 |
| Boix, F | 1 |
| Salazar, W | 1 |
| Tobeña, A | 1 |
| Kaltwasser, MT | 1 |
| Little, HJ | 1 |
| Stutzmann, JM | 1 |
| Eon, B | 1 |
| Darche, F | 1 |
| Lucas, M | 1 |
| Rataud, J | 1 |
| Piot, O | 1 |
| Blanchard, JC | 1 |
| Laduron, PM | 1 |
| Uyeno, ET | 1 |
| Davies, MF | 1 |
| Pryor, GT | 1 |
| Loew, GH | 1 |
| Bradberry, CW | 1 |
| Lory, JD | 1 |
| Roth, RH | 1 |
| Fernández-Guasti, A | 1 |
| Roldán-Roldán, G | 1 |
| Saldívar, A | 1 |
| McGregor, IS | 1 |
| Atrens, DM | 1 |
| Johnston, AL | 3 |
| Gulda, O | 1 |
| Brose, N | 1 |
| O'Neill, RD | 1 |
| Boutelle, MG | 1 |
| Fillenz, M | 1 |
| Koob, GF | 1 |
| Quintero, S | 1 |
| Henney, S | 1 |
| Lawson, P | 1 |
| Mellanby, J | 1 |
| Gray, JA | 1 |
| Duka, T | 1 |
| Giorgi, O | 1 |
| Gatta, F | 1 |
| Ableitner, A | 1 |
| Herz, A | 1 |
| Lister, RG | 2 |
| Thiébot, MH | 1 |
| Soubrié, P | 1 |
| Sanger, D | 1 |
| Glushankov, PG | 1 |
| Pliashkevich, IuG | 1 |
| Laurie, DJ | 1 |
| McCulloch, J | 1 |
| Mabbutt, PS | 1 |
| Walker, JH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blind, Placebo- and Active Comparator-controlled, Crossover Trial to Examine the Effect of Multiple Doses of CVL-865 on Panic Symptoms Induced by Carbon Dioxide Inhalation in Healthy Subject[NCT04592536] | Phase 1 | 56 participants (Actual) | Interventional | 2020-10-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for fg 7142 and Anxiety
| Article | Year |
|---|---|
Pharmacology of the beta-carboline FG-7,142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA A receptor: neurochemical, neurophysiological, and behavioral effects.
Topics: Allosteric Site; Animals; Anxiety; Behavior, Animal; Benzodiazepines; Carbolines; Drug Interactions; | 2007 |
[The effect on other individual presentations of the goldfish by FG7142 injection].
Topics: Animals; Anxiety; Behavior, Animal; Carbolines; Dose-Response Relationship, Drug; Goldfish; Predator | 2002 |
The benzodiazepines: anxiolytic and withdrawal effects.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Diazepam; Disease Models, Animal; Ethanol; Flumaz | 1991 |
Anxiogenic properties of beta-CCE and FG 7142: a review of promises and pitfalls.
Topics: Animals; Anxiety; Appetite Depressants; Carbolines; Humans; Ligands | 1988 |
1 trial available for fg 7142 and Anxiety
| Article | Year |
|---|---|
FG 7142: is this validated tool to study anxiety now forgotten?
Topics: Adult; Animals; Anxiety; Carbolines; Humans; Male; Neurotransmitter Agents | 2020 |
114 other studies available for fg 7142 and Anxiety
| Article | Year |
|---|---|
Effect of intracerebroventricular administration of two molecular forms of sulfated CCK octapeptide on anxiety-like behavior in the zebrafish danio rerio.
Topics: Animals; Anxiety; Behavior, Animal; Benzodiazepines; Brain; Carbolines; Injections, Intraventricular | 2020 |
Intracerebroventricular administration of α-melanocyte-stimulating hormone (α-MSH) enhances thigmotaxis and induces anxiety-like behavior in the goldfish Carassius auratus.
Topics: alpha-MSH; Animals; Anxiety; Behavior, Animal; Benzodiazepines; Brain; Carbolines; Female; Goldfish; | 2021 |
PLDT (planarian light/dark test): an invertebrate assay to quantify defensive responding and study anxiety-like effects.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzodiazepines; Carbolines; Darkness; Dos | 2018 |
Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1.
Topics: alpha Karyopherins; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Carbolines; Hippocampus | 2018 |
Sex differences in reward- and punishment-guided actions.
Topics: Animals; Anxiety; Association Learning; Avoidance Learning; Carbolines; Cognition; Conditioning, Ope | 2019 |
Use of the light/dark test for anxiety in adult and adolescent male rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Age Factors; Animals; Antidepressive Agents; Anxiety; Carbo | 2013 |
FG7142, yohimbine, and βCCE produce anxiogenic-like effects in the elevated plus-maze but do not affect brainstem activated hippocampal theta.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analysis of Variance; Animals; Anxiety; Biophysics; Brain S | 2013 |
Orexin A enhances locomotor activity and induces anxiogenic-like action in the goldfish, Carassius auratus.
Topics: Animals; Anxiety; Benzoxazoles; Carbolines; Diazepam; Emotions; Goldfish; Hypnotics and Sedatives; I | 2014 |
Vocalizations associated with anxiety and fear in the common marmoset (Callithrix jacchus).
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anxiety; Auditory Perception; Callithrix; Carbo | 2014 |
Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Carbolines; Male; Maze Learning; Mice; Mice | 2015 |
Anxiety Evokes Hypofrontality and Disrupts Rule-Relevant Encoding by Dorsomedial Prefrontal Cortex Neurons.
Topics: Action Potentials; Animals; Anxiety; Attention; Carbolines; Disease Models, Animal; GABA Antagonists | 2016 |
The role of anxiety in vulnerability for self-injurious behaviour: studies in a rodent model.
Topics: Analysis of Variance; Animals; Anxiety; Carbolines; Disease Models, Animal; Disease Susceptibility; | 2016 |
COLORcation: A new application to phenotype exploratory behavior models of anxiety in mice.
Topics: Algorithms; Analysis of Variance; Animals; Anxiety; Carbolines; Disease Models, Animal; Exploratory | 2016 |
Effects of the benzodiazepine inverse agonist FG7142 on the structure of anxiety-related behavior of male Wistar rats tested in hole board.
Topics: Animals; Anxiety; Behavior, Animal; Carbolines; Carrier Proteins; Drug Inverse Agonism; Environment; | 2017 |
The anxiogenic drug FG7142 increases self-injurious behavior in male rhesus monkeys (Macaca mulatta).
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Carbolines; Dose-Response Relationship, Drug; Hydroco | 2009 |
Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142.
Topics: Animals; Anxiety; Brain; Carbolines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2010 |
Anxiolytic and anxiogenic drug effects on male and female gerbils in the black-white box.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Buspirone; Caffeine; Carbolines; Central Ne | 2011 |
Cellular correlates of anxiety in CA1 hippocampal pyramidal cells of 5-HT1A receptor knockout mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Diazepam; Disease Models, Animal; Excitatory Post | 2011 |
Chronic cocaine self-administration attenuates the anxiogenic-like and stress potentiating effects of the benzodiazepine inverse agonist, FG 7142.
Topics: Animals; Anxiety; Behavior, Addictive; Benzodiazepines; Carbolines; Cocaine; Corticosterone; Dose-Re | 2011 |
Analysis of vigilant scanning behavior in mice using two-point digital video tracking.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Attention; Behavior, Animal; Carbolines; Conditioning, Psycho | 2012 |
Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systems.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Carbolines; Female; GABA Antagonists; Male; Proto-Onco | 2012 |
Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat.
Topics: Analysis of Variance; Animals; Anxiety; Body Weight; Carbolines; Defense Mechanisms; GABA Antagonist | 2012 |
Performance in anxiety and spatial memory tests following bilateral vestibular loss in the rat and effects of anxiolytic and anxiogenic drugs.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Carbolines; Disease Models, Animal; GABA Antagonis | 2012 |
Lasting consequences of traumatic events on behavioral and skeletal parameters in a mouse model for post-traumatic stress disorder (PTSD).
Topics: Animals; Anxiety; Behavior, Animal; Bone and Bones; Bone Density; Carbolines; Disease Models, Animal | 2012 |
Anxiogenic, not psychotogenic, properties of the partial inverse benzodiazepine receptor agonist FG 7142 in man.
Topics: Anxiety; Carbolines; Clinical Trials, Phase I as Topic; GABA Agonists; GABA Antagonists; GABA-A Rece | 2002 |
Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs.
Topics: Adrenergic alpha-Antagonists; Amygdala; Animals; Anxiety; Caffeine; Carbolines; Central Nervous Syst | 2003 |
Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Carbolines; Diazepam; Dose-Response Relatio | 2003 |
22-kHz ultrasonic vocalization in rats as an index of anxiety but not fear: behavioral and pharmacological modulation of affective state.
Topics: Animals; Anxiety; Behavior, Animal; Buspirone; Carbolines; Conditioning, Classical; Diagnosis, Diffe | 2003 |
The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Avoidance Learnin | 2003 |
The anxiogenic beta-carboline FG-7142 inhibits locomotor exploration similarly in postweanling and adult rats.
Topics: Age Factors; Animals; Anxiety; Carbolines; Exploratory Behavior; Motor Activity; Rats; Stress, Psych | 2003 |
Distribution of anxiogenic-induced c-Fos in the forebrain regions of developing rats.
Topics: Aging; Animals; Anxiety; Carbolines; GABA Antagonists; Immunohistochemistry; Male; Prosencephalon; P | 2003 |
Nociceptin/orphanin FQ increases anxiety-related behavior and circulating levels of corticosterone during neophobic tests of anxiety.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Carbolines; Corticost | 2004 |
Use of the elevated T-maze to study anxiety in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; | 2004 |
Genetic deletion and pharmacological blockade of CB1 receptors modulates anxiety in the shock-probe burying test.
Topics: Animals; Anxiety; Carbolines; Chlordiazepoxide; Electroshock; Gene Deletion; Male; Mice; Mice, Inbre | 2004 |
Serotonergic neurons in the median raphe nucleus regulate inhibitory avoidance but not escape behavior in the rat elevated T-maze test of anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Avoidance Learning; Carbolines; Escape Rea | 2005 |
Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anxiety; Brain Chemistry; Carbolines; Cerebellum; Fibroblas | 2005 |
Immediate-early gene expression in the central nucleus of the amygdala is not specific for anxiolytic or anxiogenic drugs.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Buspirone; Carbolines; Diazepam; | 2006 |
Reduced attention and increased impulsivity in mice lacking NPY Y2 receptors: relation to anxiolytic-like phenotype.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Attention; Behavior, Animal; Carbolines; Choice Behavior; Dia | 2006 |
Airjet and FG-7142-induced Fos expression differs in rats selectively bred for high and low anxiety-related behavior.
Topics: Air; Animals; Anxiety; Behavior, Animal; Brain; Carbolines; Dopamine beta-Hydroxylase; Escape Reacti | 2006 |
The anxiogenic drug FG-7142 increases serotonin metabolism in the rat medial prefrontal cortex.
Topics: Animals; Anxiety; Carbolines; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Male; | 2006 |
5-Hydroxytryptamine2C receptor contribution to m-chlorophenylpiperazine and N-methyl-beta-carboline-3-carboxamide-induced anxiety-like behavior and limbic brain activation.
Topics: Aminopyridines; Animals; Anxiety; Behavior, Animal; Carbolines; Indoles; Limbic System; Magnetic Res | 2007 |
Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Carbolines; Central N | 2007 |
Methylamide beta-carboline (FG 7142), an anxiogenic benzodiazepine antagonist, is also a proconvulsant.
Topics: Animals; Anxiety; Benzodiazepines; Carbolines; Convulsants; Humans; Indoles; Mice; Papio | 1983 |
Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine receptors.
Topics: Adult; Anxiety; Brain; Carbolines; Humans; Indoles; Male; Middle Aged; Receptors, Cell Surface; Rece | 1983 |
Absence of intrinsic antagonist actions of benzodiazepine antagonists on an exploratory model of anxiety in the mouse.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Carbolines; Disease Models, Animal; Dose-R | 1984 |
Does the reversal of the anticonflict effect of phenobarbital by beta-CCE and FG 7142 indicate benzodiazepine receptor-mediated anxiogenic properties?
Topics: Animals; Anxiety; Carbolines; Conflict, Psychological; Diazepam; Flunitrazepam; Humans; Indoles; Mal | 1982 |
Involvement of GABA in the facilitation of punishment suppressed behavior induced by beta-carbolines in rat.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Conditioning, Operant; Diazepam; Drug Interactions; | 1983 |
The anxiogenic action of FG 7142 in the social interaction test is reversed by chlordiazepoxide and Ro 15-1788 but not by CGS 8216.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Chlordiazepoxide; Convulsants; Flumazenil; Humans; | 1984 |
Carbon dioxide inhalation, stress and anxiogenic drugs reduce the function of GABAA receptor complex in the rat brain.
Topics: Administration, Inhalation; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Brain Chemistry; | 1993 |
The benzodiazepine receptor inverse agonist FG 7142 induces cholecystokinin gene expression in rat brain.
Topics: Amygdala; Animals; Anxiety; Brain; Carbolines; Cholecystokinin; Dose-Response Relationship, Drug; GA | 1995 |
Ethopharmacological analysis of rat behavior on the elevated plus-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Appetite Depressants; Behavior, Animal; Carbolines; Explorato | 1994 |
Role of benzodiazepine receptors located in the dorsal periaqueductal grey of rats in anxiety.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Anxiety; Appetite Depressants; C | 1993 |
"One-trial tolerance" to the anxiolytic actions of benzodiazepines in the elevated plus-maze, or the development of a phobic state?
Topics: Animals; Anti-Anxiety Agents; Anxiety; Appetite Depressants; Carbolines; Cats; Chlordiazepoxide; Dia | 1993 |
An animal model for measuring behavioral responses to anxiogenic and anxiolytic manipulations.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Carbolines; Cues; Diazepam; Dose-Response R | 1994 |
Sex differences in open-field behavior in response to the beta-carboline FG 7142 in rats.
Topics: Animals; Anxiety; Behavior, Animal; Carbolines; Depression, Chemical; Dose-Response Relationship, Dr | 1993 |
Factors that modulate inescapable shock-induced reductions in daily activity in the rat.
Topics: Animals; Anxiety; Brain Chemistry; Carbolines; Electroshock; Helplessness, Learned; Male; Motor Acti | 1993 |
Stressor controllability, social interaction, and benzodiazepine systems.
Topics: Animals; Anxiety; Carbolines; Chlordiazepoxide; Dose-Response Relationship, Drug; Electroshock; Flum | 1993 |
Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat.
Topics: Animals; Anxiety; Appetite Depressants; Behavior, Animal; Carbolines; Convulsants; Dose-Response Rel | 1995 |
Ethopharmacological analysis of the effects of putative 'anxiogenic' agents in the mouse elevated plus-maze.
Topics: Animals; Anxiety; Appetite Depressants; Behavior, Animal; Carbolines; Dose-Response Relationship, Dr | 1995 |
Effect of a pharmacological stressor on glutamate efflux in the prefrontal cortex.
Topics: Animals; Anxiety; Carbolines; Chromatography, High Pressure Liquid; Diazepam; Extracellular Space; G | 1996 |
The cardiovascular startle response: anxiety and the benzodiazepine receptor complex.
Topics: Animals; Anxiety; Blood Pressure; Carbolines; GABA-A Receptor Agonists; Heart Rate; Male; Rats; Rats | 1997 |
Reversal of benzodiazepine inverse agonist FG 7142-induced anxiety syndrome by neurosteroids in mice.
Topics: Animals; Anxiety; Benzodiazepines; Benzodiazepinones; Carbolines; Flumazenil; GABA Antagonists; GABA | 1997 |
Characterization of rat exploratory behavior using the exploration box test.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Buspirone; Carbolines; Diazepa | 1997 |
The anxiogenic agents, yohimbine and FG 7142, disrupt the noradrenergic response to novelty.
Topics: Adrenergic alpha-Agonists; Animals; Anxiety; Brain Chemistry; Carbolines; Environment; GABA Antagoni | 1998 |
Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Chlordiazepoxide; Convulsants; Diazepam; Explorat | 1998 |
Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior. Study 1--Role of NMDA receptors in efferent transmission from the cat amygdala.
Topics: Aggression; Amygdala; Animals; Anxiety; Arousal; Brain Mapping; Carbolines; Cats; Efferent Pathways; | 1998 |
Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior. Study 2--The effects on behavior of block of NMDA receptors prior to injection of
Topics: 2-Amino-5-phosphonovalerate; Animals; Anxiety; Arousal; Brain Mapping; Carbolines; Cats; Dominance, | 1998 |
Cholinergic inputs to the rat medial prefrontal cortex mediate potentiation of the cardiovascular defensive response by the anxiogenic benzodiazephine receptor partial inverse agonist FG 7142.
Topics: Animals; Anxiety; Atropine; Carbolines; Cardiovascular Physiological Phenomena; Cholinergic Agents; | 1999 |
Neuroanatomical targets of anxiogenic drugs in the hindbrain as revealed by Fos immunocytochemistry.
Topics: Adrenergic alpha-Antagonists; Animals; Anxiety; Caffeine; Carbolines; Central Nervous System Stimula | 2000 |
Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior: study 3--the effects on amygdala efferent physiology of block of NMDA receptors p
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Carbolines; Cats; Electrodes, Implanted; Evoked Potent | 1998 |
Inhibition of stress- or anxiogenic-drug-induced increases in dopamine release in the rat prefrontal cortex by long-term treatment with antidepressant drugs.
Topics: Animals; Antidepressive Agents; Anxiety; Carbolines; Dopamine; Dose-Response Relationship, Drug; Dru | 2001 |
Evidence that long-lasting potentiation in limbic circuits mediating defensive behaviour in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of benzodiazepine receptors.
Topics: Aggression; Animals; Anxiety; Behavior, Animal; Carbolines; Catheterization; Cats; Flumazenil; Funct | 2000 |
Evidence that long-lasting potentiation of amygdala efferents in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of GABA tone in initiation of brain and behavioural changes.
Topics: Aggression; Amygdala; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Brain Chemistry; Carbolin | 2000 |
Exposure of a 'witness rat' to one treated with beta-carboline FG 7142 does not increase dopamine turnover in the medial prefrontal cortex of the 'witness rat'.
Topics: Animals; Anxiety; Behavior, Animal; Carbolines; Dopamine; Fear; GABA Antagonists; Male; Neural Pathw | 2001 |
Chronic treatment with imipramine or mirtazapine antagonizes stress- and FG7142-induced increase in cortical norepinephrine output in freely moving rats.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Carbolines; Cerebral Cortex | 2002 |
Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Caffeine; Ca | 2002 |
Inhibition by venlafaxine of the increase in norepinephrine output in rat prefrontal cortex elicited by acute stress or by the anxiogenic drug FG 7142.
Topics: Animals; Anxiety; Carbolines; Cyclohexanols; Dose-Response Relationship, Drug; Electroshock; Extrace | 2002 |
FG 7142 selectively decreases nonpunished responding, but has no anxiogenic effects on time allocation in a conflict schedule.
Topics: Animals; Anxiety; Carbolines; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Dose | 1992 |
Beta--CCE and FG 7142 increase defensiveness during intraspecies encounters in mice.
Topics: Aggression; Animals; Anxiety; Carbolines; Escape Reaction; GABA-A Receptor Antagonists; Interpersona | 1992 |
Anxiogenic drugs beta-CCE and FG 7142 increase extracellular dopamine levels in nucleus accumbens.
Topics: Analysis of Variance; Animals; Anxiety; Carbolines; Dopamine; Male; Microdialysis; Motor Activity; N | 1992 |
Behavioural effects of anxiogenic agents in the common marmoset.
Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Caffeine; Callithrix; Carbolines; Diazepam; Motor A | 1992 |
Differential effects of anxiogenic central and peripheral benzodiazepine receptor ligands in tests of learning and memory.
Topics: Animals; Anxiety; Avoidance Learning; Benzodiazepinones; Carbolines; Conditioning, Operant; Isoquino | 1991 |
Stimulant effect of the beta-carboline FG 7142 in the open-field test.
Topics: Animals; Anxiety; Behavior, Animal; Carbolines; Motor Activity; Rats; Rats, Inbred Strains; Receptor | 1991 |
The early acquisition of two-way (shuttle-box) avoidance as an anxiety-mediated behavior: psychopharmacological validation.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Azides; Benzodiazepines; Carbolines; Male | 1991 |
Acoustic startle induced ultrasonic vocalization in the rat: a novel animal model of anxiety?
Topics: Animals; Anti-Anxiety Agents; Anxiety; Appetite Depressants; Arousal; Carbolines; Diazepam; Disease | 1991 |
Are 5-HT2 antagonists endowed with anxiolytic properties in rodents?
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Cerebral Cortex; Cyclic S-Oxides; Dose-Response R | 1991 |
Selective effect on punished versus unpunished responding in a conflict test as the criterion for anxiogenic activity.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Conflict, Psychological; Electroshock; Male; Pent | 1990 |
The anxiogenic beta-carboline FG 7142 selectively increases dopamine release in rat prefrontal cortex as measured by microdialysis.
Topics: Animals; Anxiety; Benzodiazepines; Carbolines; Corpus Striatum; Dialysis; Dopamine; Flumazenil; Fron | 1991 |
Pharmacological manipulation of anxiety and male rat sexual behavior.
Topics: Animals; Anxiety; Carbolines; Copulation; Diazepam; Flumazenil; Male; Psychomotor Performance; Rats; | 1990 |
Stressor-like effects of FG-7142 on medial prefrontal cortex self-stimulation.
Topics: Animals; Anxiety; Carbolines; Electric Stimulation; Frontal Lobe; Male; Rats; Rats, Inbred Strains; | 1990 |
Ibotenic acid lesions of the medial prefrontal cortex potentiate FG-7142-induced attenuation of exploratory activity in the rat.
Topics: Animals; Anxiety; Carbolines; Cerebral Cortex; Exploratory Behavior; Ibotenic Acid; Male; Motor Acti | 1990 |
Sodium phenobarbitone reverses the anxiogenic effects of compounds acting at three different central sites.
Topics: Animals; Anxiety; Appetite Depressants; Carbolines; Exploratory Behavior; Male; Pentylenetetrazole; | 1989 |
The behavioural effects of benzodiazepine receptor ligands in mice are inhibited by adamantylamide dipeptide.
Topics: Adjuvants, Immunologic; Amantadine; Animals; Anxiety; Behavior, Animal; Carbolines; Diazepam; Dipept | 1989 |
The effects of anxiolytic and anxiogenic benzodiazepine receptor ligands on motor activity and levels of ascorbic acid in the nucleus accumbens and striatum of the rat.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Appetite Depressants; Ascorbic Acid; Carbolines; Circadian Rh | 1989 |
Can anti-panic drugs antagonise the anxiety produced in the rat by drugs acting at the GABA-benzodiazepine receptor complex?
Topics: Animals; Anxiety; Carbolines; Clonidine; Fear; Imipramine; Male; Panic; Pentylenetetrazole; Rats; Ra | 1987 |
Propranolol antagonizes the enhanced conditioned fear produced by corticotropin releasing factor.
Topics: Animals; Anxiety; Carbolines; Conditioning, Psychological; Corticotropin-Releasing Hormone; Fear; Fl | 1988 |
The effects of compounds related to gamma-aminobutyrate and benzodiazepine receptors on behavioural responses to anxiogenic stimuli in the rat: punished barpressing.
Topics: Amobarbital; Animals; Anti-Anxiety Agents; Anxiety; Baclofen; Bicuculline; Carbolines; Chlordiazepox | 1985 |
Triazolobenzodiazepines antagonize the effects of anxiogenic drugs mediated at three different central nervous system sites.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Brain; Carbolines; Male; Motor A | 1985 |
Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinones; Buspirone; Carbolines; Co | 1986 |
Anxiety: its generation by drugs and by their withdrawal.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Carbolines; Humans; Norepinephrine; Receptor | 1986 |
Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat.
Topics: Animals; Anxiety; Carbolines; Drug Interactions; Male; Rats; Rats, Inbred Strains; Receptors, Seroto | 1987 |
Chronic treatment with imipramine does not reverse the effects of 3 anxiogenic compounds in a test of anxiety in the rat.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Drug Combinations; Imipramine; Male; Pentylenetet | 1987 |
An anxiogenic benzodiazepine receptor ligand induces learned helplessness.
Topics: Animals; Anxiety; Avoidance Learning; Carbolines; Electroshock; Helplessness, Learned; Male; Rats; R | 1985 |
The effects of putative anxiogenic compounds (FG 7142, CGS 8216 and Ro 15-1788) on the rat corticosterone response.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Corticosterone; Flumazenil; Male; Pyrazoles; Rats; | 1985 |
Long-lasting proconflict effect induced by chronic administration of the beta-carboline derivative FG 7142.
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Conflict, Psychological; Disease Models, Animal; Dr | 1985 |
Changes in local cerebral glucose utilization induced by the beta-carbolines FG 7142 and DMCM reveal brain structures involved in the control of anxiety and seizure activity.
Topics: Animals; Anxiety; Autoradiography; Brain; Carbolines; Convulsants; Deoxyglucose; Flumazenil; Glucose | 1987 |
The use of a plus-maze to measure anxiety in the mouse.
Topics: Animals; Anxiety; Appetite Depressants; Behavior, Animal; Carbolines; Chlordiazepoxide; Ethanol; Mal | 1987 |
[Effect of amino acid derivatives of beta-carboline on the evoked activity of hippocampal neurons].
Topics: Animals; Anxiety; Carbolines; Culture Techniques; Electric Stimulation; Evoked Potentials; Glycine; | 1988 |
Interactions of three benzodiazepine receptor inverse agonists with ethanol in a plus-maze test of anxiety.
Topics: Animals; Anxiety; Azides; Benzodiazepines; Carbolines; Dose-Response Relationship, Drug; Ethanol; Ex | 1988 |
The effects of FG 7142 upon local cerebral glucose utilization suggest overlap between limbic structures important in anxiety and convulsions.
Topics: Animals; Anxiety; Brain; Carbolines; Deoxy Sugars; Deoxyglucose; Dose-Response Relationship, Drug; L | 1988 |
Comparison of adaptive responses in familiar and novel environments: modulatory factors.
Topics: Adaptation, Psychological; Animals; Anxiety; Carbolines; Environment; Grooming; Pentylenetetrazole; | 1988 |
FG 7142 and its anxiety-inducing effects in humans.
Topics: Anxiety; Appetite Depressants; Carbolines; Humans; Infusions, Intravenous | 1987 |
Effects of the beta-carboline, FG 7142, in the social interaction test of anxiety and the holeboard: correlations between behaviour and plasma concentrations.
Topics: Animals; Anxiety; Carbolines; Humans; Indoles; Male; Motor Activity; Rats; Social Behavior; Time Fac | 1985 |
Chlordiazepoxide enhances the anxiogenic action of CGS 8216 in the social interaction test: evidence for benzodiazepine withdrawal?
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Chlordiazepoxide; Flumazenil; Humans; Male; Pyrazol | 1985 |