fg-4592 and Myocardial-Infarction

fg-4592 has been researched along with Myocardial-Infarction* in 1 studies

Other Studies

1 other study(ies) available for fg-4592 and Myocardial-Infarction

Article	Year
Roxadustat Markedly Reduces Myocardial Ischemia Reperfusion Injury in Mice. Circulation journal : official journal of the Japanese Circulation Society, 2020, 05-25, Volume: 84, Issue:6 Ischemic preconditioning (IPC) is an effective procedure to protect against ischemia/reperfusion (I/R) injury. Hypoxia-inducible factor-1α (Hif-1α) is a key molecule in IPC, and roxadustat (RXD), a first-in-class prolyl hydroxylase domain-containing protein inhibitor, has been recently developed to treat anemia in patients with chronic kidney disease. Thus, we investigated whether RXD pretreatment protects against I/R injury.Methods and Results:RXD pretreatment markedly reduced the infarct size and suppressed plasma creatinine kinase activity in a murine I/R model. Analysis of oxygen metabolism showed that RXD could produce ischemic tolerance by shifting metabolism from aerobic to anaerobic respiration.. RXD pretreatment may be a novel strategy against I/R injury. Topics: Animals; Cell Respiration; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Glycine; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Isoquinolines; Male; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Signal Transduction	2020

Article

Year

Roxadustat Markedly Reduces Myocardial Ischemia Reperfusion Injury in Mice.

Circulation journal : official journal of the Japanese Circulation Society, 2020, 05-25, Volume: 84, Issue:6

Ischemic preconditioning (IPC) is an effective procedure to protect against ischemia/reperfusion (I/R) injury. Hypoxia-inducible factor-1α (Hif-1α) is a key molecule in IPC, and roxadustat (RXD), a first-in-class prolyl hydroxylase domain-containing protein inhibitor, has been recently developed to treat anemia in patients with chronic kidney disease. Thus, we investigated whether RXD pretreatment protects against I/R injury.Methods and Results:RXD pretreatment markedly reduced the infarct size and suppressed plasma creatinine kinase activity in a murine I/R model. Analysis of oxygen metabolism showed that RXD could produce ischemic tolerance by shifting metabolism from aerobic to anaerobic respiration.. RXD pretreatment may be a novel strategy against I/R injury.

Topics: Animals; Cell Respiration; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Glycine; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Isoquinolines; Male; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Signal Transduction

2020