fg-4592 and Carcinoma--Lewis-Lung

Tumor blood vessels have leaky and low blood flow properties, which lead to hypoxia and low nutrient levels in the tumor tissue area known as the tumor microenvironment (TME). We reported that the prolyl-hydroxylase (PHD) inhibitor Roxadustat normalized tumor blood vessels, improved tumor tissue perfusion, and re-oxygenated the tumor tissue. Recently, several PHD inhibitors including Roxadustat, Daprodustat, Molidustat, and Vadadustat, were evaluated in clinical trials and approved for treating renal anemia. In this study, we showed that PHD inhibitors reconstituted tumor blood vessels and improved the TME, and some agents exhibited differential effects on tumors in a mouse model.

Topics: Animals; Carcinoma, Lewis Lung; Glycine; Isoquinolines; Male; Mice, Inbred C57BL; Oxygen Consumption; Picolinic Acids; Prolyl-Hydroxylase Inhibitors; Tumor Cells, Cultured; Tumor Microenvironment