fexofenadine has been researched along with Torsade de Pointes in 4 studies
fexofenadine: a second generation antihistamine; metabolite of the antihistaminic drug terfenadine; structure in first source; RN refers to HCl
fexofenadine : A piperidine-based anti-histamine compound.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fexofenadine HCl has been investigated more extensively for possible electrophysiological effects than any other antihistamine." | 2.69 | Cardiovascular safety of fexofenadine HCl. ( Ahlbrandt, R; Brown, AM; Mason, J; Pratt, C; Rampe, D; Reynolds, R; Russell, T, 1999) |
| "Ebastine also inhibit potassium channels, cloned human Kv 1." | 2.41 | [The effect of second generation histamine antagonists on the heart]. ( Górska, M; Grzelewska-Rzymowska, I; Pietrzkowicz, M, 2001) |
| " This paper reviews the pharmacokinetic properties of these second-generation agents and is intended to provide comparisons that help explain differences in dosing profiles and drug interactions for members of this class of drugs." | 2.40 | Pharmacokinetic overview of oral second-generation H1 antihistamines. ( Estes, KS; González, MA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| González, MA | 1 |
| Estes, KS | 1 |
| Pratt, C | 1 |
| Brown, AM | 1 |
| Rampe, D | 1 |
| Mason, J | 1 |
| Russell, T | 1 |
| Reynolds, R | 1 |
| Ahlbrandt, R | 1 |
| Shaikh, WA | 1 |
| Grzelewska-Rzymowska, I | 1 |
| Pietrzkowicz, M | 1 |
| Górska, M | 1 |
2 reviews available for fexofenadine and Torsade de Pointes
| Article | Year |
|---|---|
Pharmacokinetic overview of oral second-generation H1 antihistamines.
Topics: Astemizole; Blood-Brain Barrier; Cetirizine; Histamine H1 Antagonists; Humans; Loratadine; Structure | 1998 |
[The effect of second generation histamine antagonists on the heart].
Topics: Animals; Area Under Curve; Astemizole; Butyrophenones; Electrocardiography; Heart; Histamine H1 Anta | 2001 |
2 trials available for fexofenadine and Torsade de Pointes
| Article | Year |
|---|---|
Cardiovascular safety of fexofenadine HCl.
Topics: Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Electrocardiography; Hista | 1999 |
The changing face of antihistamines and cardiac adverse drug reactions: a clinical perspective.
Topics: Cardiovascular Diseases; Drug Interactions; Electrocardiography; Erythromycin; Female; Histamine H1 | 2000 |