Page last updated: 2024-10-27

fexofenadine and Itching

fexofenadine has been researched along with Itching in 17 studies

fexofenadine: a second generation antihistamine; metabolite of the antihistaminic drug terfenadine; structure in first source; RN refers to HCl
fexofenadine : A piperidine-based anti-histamine compound.

Research Excerpts

ExcerptRelevanceReference
"H1-antihistamines are the first-line treatment of chronic idiopathic urticaria (CIU), but CIU is occasionally refractory to the conventional treatment doses."9.17Comparison of the efficacy of fexofenadine 120 and 240 mg/day on chronic idiopathic urticaria and histamine-induced skin responses in Japanese populations. ( Kabashima, K; Miyachi, Y; Nakahigashi, K; Tanizaki, H, 2013)
"Fexofenadine (n = 201) significantly decreased the severity of pruritus compared with placebo (n = 199) (mean change in score -0."9.10Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study. ( Harada, S; Inagi, M; Kawashima, M; Nakagawa, H; Noguchi, T; Tango, T, 2003)
"In this 4-week, multicenter, placebo-controlled study, 439 patients with moderate to severe pruritus and urticaria received 1 of 4 oral doses of fexofenadine HCl (20, 60, 120, or 240 mg twice a day) or placebo."9.09A double-blind, placebo-controlled trial of fexofenadine HCl in the treatment of chronic idiopathic urticaria. ( Finn, AF; Fretwell, R; Kaplan, AP; Long, J; Qu, R, 1999)
" In this study, we investigated the anti-pruritic effect of the antihistamine, fexofenadine, on the itch of contact dermatitis that was induced by topical application of diphenylcyclopropenone for the treatment for alopecia areata."7.73Fexofenadine, an H1-receptor antagonist, partially but rapidly inhibits the itch of contact dermatitis induced by diphenylcyclopropenone in patients with alopecia areata. ( Arakawa, S; Fujiwara, S; Hatano, Y; Katagiri, K, 2006)
"H1-antihistamines are the first-line treatment of chronic idiopathic urticaria (CIU), but CIU is occasionally refractory to the conventional treatment doses."5.17Comparison of the efficacy of fexofenadine 120 and 240 mg/day on chronic idiopathic urticaria and histamine-induced skin responses in Japanese populations. ( Kabashima, K; Miyachi, Y; Nakahigashi, K; Tanizaki, H, 2013)
"Fexofenadine (n = 201) significantly decreased the severity of pruritus compared with placebo (n = 199) (mean change in score -0."5.10Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study. ( Harada, S; Inagi, M; Kawashima, M; Nakagawa, H; Noguchi, T; Tango, T, 2003)
"In this 4-week, multicenter, placebo-controlled study, 439 patients with moderate to severe pruritus and urticaria received 1 of 4 oral doses of fexofenadine HCl (20, 60, 120, or 240 mg twice a day) or placebo."5.09A double-blind, placebo-controlled trial of fexofenadine HCl in the treatment of chronic idiopathic urticaria. ( Finn, AF; Fretwell, R; Kaplan, AP; Long, J; Qu, R, 1999)
"Pretreatment with fexofenadine during venom immunotherapy reduces local allergic reactions and generalized symptoms of the urticaria and angioedema type."5.09Reduction of side-effects from ultrarush immunotherapy with honeybee venom by pretreatment with fexofenadine: a double-blind, placebo-controlled trial. ( Hari, Y; Müller, U; Reimers, A, 2000)
" However, fexofenadine probably leads to a small improvement in patient-assessed pruritus, with probably no significant difference in the amount of treatment used to prevent eczema flares."5.01Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema. ( Apfelbacher, CJ; Böhmer, MM; Carter, B; Jupiter, A; Matterne, U; Weisshaar, E, 2019)
"Urticaria is mainly caused by mast cell-derived histamine through the histamine H(1) receptor."3.78Effects of bepotastine and fexofenadine on histamine-induced flare, wheal and itch. ( Fukuoka, M; Ikoma, A; Kabashima, K; Miyachi, Y; Tanizaki, H, 2012)
" In this study, we investigated the anti-pruritic effect of the antihistamine, fexofenadine, on the itch of contact dermatitis that was induced by topical application of diphenylcyclopropenone for the treatment for alopecia areata."3.73Fexofenadine, an H1-receptor antagonist, partially but rapidly inhibits the itch of contact dermatitis induced by diphenylcyclopropenone in patients with alopecia areata. ( Arakawa, S; Fujiwara, S; Hatano, Y; Katagiri, K, 2006)
"Levocetirizine was more inhibitory than fexofenadine on wheal, flare and pruritus (p < 0."2.78The inhibition by levocetirizine and fexofenadine of the histamine-induced wheal and flare response in healthy Caucasian and Japanese volunteers. ( Church, MK; Maurer, M; Schoepke, N, 2013)
"Fexofenadine (180 mg/d) was taken during the run-in period and subsequently throughout the study and follow-up as required."2.73Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot study. ( Borzova, E; Grattan, CE; Konstantinou, GN; Leslie, KS; Rutherford, A, 2008)
"Treatment with fexofenadine resulted in inhibition of allergen-induced symptoms and increased vascular permeability, but not the release of histamine and tryptase."2.70Effects of fexofenadine on the early response to nasal allergen challenge. ( Allocco, FT; Baroody, FM; deTineo, M; Naclerio, RM; Votypka, V, 2002)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.88)18.2507
2000's9 (52.94)29.6817
2010's7 (41.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X1
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Matterne, U1
Böhmer, MM1
Weisshaar, E1
Jupiter, A1
Carter, B1
Apfelbacher, CJ1
Tanizaki, H2
Nakahigashi, K1
Miyachi, Y2
Kabashima, K2
Hashimoto, T1
Satoh, T1
Borzova, E1
Rutherford, A1
Konstantinou, GN1
Leslie, KS1
Grattan, CE1
Kamei, H1
Isaji, A1
Noda, Y1
Ishikawa, K1
Senzaki, K1
Yamada, K1
Sugiura, K1
Tomita, Y1
Nabeshima, T1
Ikoma, A1
Fukuoka, M1
Schoepke, N1
Church, MK1
Maurer, M1
Scherer, CR1
Lerche, C1
Decher, N1
Dennis, AT1
Maier, P1
Ficker, E1
Busch, AE1
Wollnik, B1
Steinmeyer, K1
Allocco, FT1
Votypka, V1
deTineo, M1
Naclerio, RM1
Baroody, FM1
Kawashima, M1
Tango, T1
Noguchi, T1
Inagi, M1
Nakagawa, H1
Harada, S1
Lennox, RD2
Leahy, MJ1
Shikiar, R1
Harding, G1
Leahy, M1
Katagiri, K1
Arakawa, S1
Hatano, Y1
Fujiwara, S1
Benhamou, AH1
Vanini, G1
Lantin, JP1
Eigenmann, PA1
Finn, AF1
Kaplan, AP1
Fretwell, R1
Qu, R1
Long, J1
Reimers, A1
Hari, Y1
Müller, U1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Efficacy and Consistency of Action of Levocetirizine 5 mg Once Daily With Fexofenadine 60 mg Twice Daily in the Histamine Induced Wheal, Flare and Itch Response[NCT01586091]Phase 418 participants (Actual)Interventional2011-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Flaire Diameter (mm)

Flaire diameter was measured with a transparent ruler as the mean of the largest diameter and the diameter at right angles to this. (NCT01586091)
Timeframe: 24 hours per treatment

Interventionmm (Mean)
Placebo69.4
Levocetirizin20.4
Fexofenadine39.9

Pruritus as Assessed by the VAS Score

"We measured drug concentrations and various aspects of skin provocation testing such as itch intensity and wheal size. Measurements made at each time point were as followed: Pruritus was assessed every 30 s for 10 min after SPT using a visual analogue scale (VAS) score with a 0 and 100 at the two ex- tremes of an unmarked 100 mm line with higher values indicating greater puritus. The mean VAS for each 10 min was calculated and used as a primary end Point." (NCT01586091)
Timeframe: up to 10 minutes after skin prick test performed 24 hours after drug administration

Interventionmm (Mean)
Levocetirizin11.5
Fexofenadine25.4
Placebo46.0

Wheal Volume (cm3)

Wheal volume was measured by a non-contact three dimensional measurement system (PRIMOS contact, GFM Messtechnik GmbH, Teltow, Germany). (NCT01586091)
Timeframe: 24 hours per treatment

Interventioncm3 (Mean)
Placebo174.6
Levocetirizin35.2
Fexofenadine106.3

Reviews

1 review available for fexofenadine and Itching

ArticleYear
Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema.
    The Cochrane database of systematic reviews, 2019, Jan-22, Volume: 1

    Topics: Administration, Oral; Administration, Topical; Adult; Cetirizine; Chemotherapy, Adjuvant; Child; Ecz

2019

Trials

9 trials available for fexofenadine and Itching

ArticleYear
Comparison of the efficacy of fexofenadine 120 and 240 mg/day on chronic idiopathic urticaria and histamine-induced skin responses in Japanese populations.
    The Journal of dermatological treatment, 2013, Volume: 24, Issue:6

    Topics: Adult; Chronic Disease; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Ant

2013
Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot study.
    Journal of the American Academy of Dermatology, 2008, Volume: 59, Issue:5

    Topics: Adult; Drug Resistance; Female; Histamine H1 Antagonists; Humans; Male; Pilot Projects; Prospective

2008
Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers.
    Archives of dermatological research, 2012, Volume: 304, Issue:4

    Topics: Adolescent; Dibenzoxepins; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Olop

2012
The inhibition by levocetirizine and fexofenadine of the histamine-induced wheal and flare response in healthy Caucasian and Japanese volunteers.
    Acta dermato-venereologica, 2013, Volume: 93, Issue:3

    Topics: Adult; Asian People; Cetirizine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind

2013
Effects of fexofenadine on the early response to nasal allergen challenge.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 89, Issue:6

    Topics: Adolescent; Adult; Allergens; Biomarkers; Capillary Permeability; Cross-Over Studies; Double-Blind M

2002
Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study.
    The British journal of dermatology, 2003, Volume: 148, Issue:6

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Dermatitis, Atopic; Dermatologic Agents; Double-Blind

2003
Validation of the Dermatology Life Quality Index as an outcome measure for urticaria-related quality of life.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2004, Volume: 93, Issue:2

    Topics: Chronic Disease; Dermatology; Dose-Response Relationship, Drug; Double-Blind Method; Histamine H1 An

2004
A double-blind, placebo-controlled trial of fexofenadine HCl in the treatment of chronic idiopathic urticaria.
    The Journal of allergy and clinical immunology, 1999, Volume: 104, Issue:5

    Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Double-Blind Method; Female; Histamine H1 Antagonis

1999
Reduction of side-effects from ultrarush immunotherapy with honeybee venom by pretreatment with fexofenadine: a double-blind, placebo-controlled trial.
    Allergy, 2000, Volume: 55, Issue:5

    Topics: Adolescent; Adult; Angioedema; Anti-Allergic Agents; Bee Venoms; Double-Blind Method; Drug Therapy,

2000

Other Studies

7 other studies available for fexofenadine and Itching

ArticleYear
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
Generalized pruritus in primary sclerosing cholangitis: implications of histamine release by lysophosphatidic acid.
    The British journal of dermatology, 2015, Volume: 173, Issue:5

    Topics: Adolescent; Cholangitis, Sclerosing; Histamine H1 Antagonists, Non-Sedating; Histamine Release; Huma

2015
Effects of bepotastine and fexofenadine on histamine-induced flare, wheal and itch.
    International archives of allergy and immunology, 2012, Volume: 158, Issue:2

    Topics: Adult; Female; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Piperidines; Pruritu

2012
The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia.
    British journal of pharmacology, 2002, Volume: 137, Issue:6

    Topics: Aged; Amino Acid Sequence; Amino Acid Substitution; Animals; Arrhythmias, Cardiac; Base Sequence; Bl

2002
Minimal important difference (MID) of the Dermatology Life Quality Index (DLQI): results from patients with chronic idiopathic urticaria.
    Health and quality of life outcomes, 2005, May-20, Volume: 3

    Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Clinical Trials, Phase III as Topic; Data Interpret

2005
Fexofenadine, an H1-receptor antagonist, partially but rapidly inhibits the itch of contact dermatitis induced by diphenylcyclopropenone in patients with alopecia areata.
    The Journal of dermatology, 2006, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Aged; Alopecia Areata; Cohort Studies; Cyclopropanes; Dermatitis, Contact; Dose-R

2006
Antihistamine and sodium cromoglycate medication for food cold water exercise-induced anaphylaxis.
    Allergy, 2007, Volume: 62, Issue:12

    Topics: Adolescent; Anaphylaxis; Anti-Asthmatic Agents; Cold Temperature; Cromolyn Sodium; Drug Therapy, Com

2007