Page last updated: 2024-10-27

fexofenadine and Asthma

fexofenadine has been researched along with Asthma in 13 studies

fexofenadine: a second generation antihistamine; metabolite of the antihistaminic drug terfenadine; structure in first source; RN refers to HCl
fexofenadine : A piperidine-based anti-histamine compound.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"Fourteen atopic patients with mild-to-moderate asthma (forced expiratory volume in 1 second of 76%) completed a double-blind, randomized, crossover study consisting of 3-week treatment blocks of either fluticasone propionate-salmeterol, 250 microg twice daily, or fluticasone propionate alone, 250 microg twice daily, in conjunction with either fexofenadine, 180 mg once daily, or matched placebo."9.11Addition of fexofenadine to inhaled corticosteroid therapy to reduce inflammatory biomarkers in atopic asthma. ( Fardon, TC; Hodge, MR; Lee, DK; Lipworth, BJ, 2005)
"The goal of the study was to determine if pranlukast has effects on the upper and lower airways through a comparison of the effects of fexofenadine and pranlukast on airway hyperresponsiveness in non-asthmatic patients with cedar pollinosis before the Japanese cedar pollen season and during the peak pollen season."5.14Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis. ( Fukuda, T; Kashima, R; Okada, T; Sagara, H; Yukawa, T, 2009)
"We elected to evaluate the effects of repeated dosing with fexofenadine (FEX) and montelukast (ML) at clinically recommended doses in ICS-treated asthmatic patients using adenosine monophosphate (AMP) bronchial challenge as the primary outcome."5.11Repeated dosing effects of mediator antagonists in inhaled corticosteroid-treated atopic asthmatic patients. ( Haggart, K; Jackson, CM; Lee, DK; Lipworth, BJ, 2004)
"Fourteen atopic patients with mild-to-moderate asthma (forced expiratory volume in 1 second of 76%) completed a double-blind, randomized, crossover study consisting of 3-week treatment blocks of either fluticasone propionate-salmeterol, 250 microg twice daily, or fluticasone propionate alone, 250 microg twice daily, in conjunction with either fexofenadine, 180 mg once daily, or matched placebo."5.11Addition of fexofenadine to inhaled corticosteroid therapy to reduce inflammatory biomarkers in atopic asthma. ( Fardon, TC; Hodge, MR; Lee, DK; Lipworth, BJ, 2005)
"Sixteen atopic patients with mild-to-moderate asthma of whom 10 were receiving inhaled corticosteroid therapy (all had positive results to house dust mite on skin prick testing) were randomized in a double-blind, placebo-controlled, cross-over fashion to receive single doses of 5 mg of desloratadine, 180 mg of fexofenadine hydrochloride (FEX), 5 mg of levocetirizine dihydrochloride (LEV), or placebo, with AMP challenge performed 12 hours after dosing."5.10Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma. ( Bates, CE; Currie, GP; Lee, DK; Lipworth, BJ, 2003)
"We studied, separately, the effects of the histamine antagonist, fexofenadine hydrochloride, and the leukotriene antagonist, montelukast sodium, and their placebos on airway sensitivity to and recovery from inhaled mannitol in subjects with asthma."5.09Fexofenadine decreases sensitivity to and montelukast improves recovery from inhaled mannitol. ( Anderson, SD; Brannan, JD; Chan, HK; Gomes, K; King, GG; Seale, JP, 2001)
" However, the effect of long-term use of montelukast, a cystenil leukotriene receptor antagonist, on skin prick test hasn't been full elucidated."2.78The effect of montelukast on wheal reactions in skin prick tests: a double-blind-placebo-controlled randomized trial. ( Aydogan, M; Aydogmus, CY; Bulan, K; Siraneci, R, 2013)
" Safety was evaluated through adverse event reporting, electrocardiograms, and pre- and posttreatment laboratory panels and physical examinations."2.70Safety of fexofenadine in children treated for seasonal allergic rhinitis. ( Bernstein, DI; Goldsobel, A; Graft, DF; Long, J; Meltzer, EO; Portnoy, J, 2001)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (92.31)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bulan, K1
Aydogan, M1
Siraneci, R1
Aydogmus, CY1
Izumi, N1
Mizuguchi, H1
Umehara, H1
Ogino, S1
Fukui, H1
Sagara, H1
Yukawa, T1
Kashima, R1
Okada, T1
Fukuda, T1
Li, AM1
Abdullah, VJ1
Tsen, CS1
Au, CT1
Lam, HS1
So, HK1
Chan, MH1
Leung, AW1
Chan, IH1
Lam, CW1
Ng, PC1
Shaikh, WA1
Shaikh, SW1
Lee, DK3
Bates, CE1
Currie, GP1
Lipworth, BJ3
Grzelewska-Rzymowska, I1
KroczyƄska-Bednarek, J1
Pietrzkowicz, M1
Jackson, CM1
Haggart, K1
Fardon, TC1
Hodge, MR1
Brannan, JD1
Anderson, SD1
Gomes, K1
King, GG1
Chan, HK1
Seale, JP1
Graft, DF1
Bernstein, DI1
Goldsobel, A1
Meltzer, EO1
Portnoy, J1
Long, J1
Wilson, AM1

Reviews

1 review available for fexofenadine and Asthma

ArticleYear
Are antihistamines useful in managing asthma?
    Current opinion in allergy and clinical immunology, 2002, Volume: 2, Issue:1

    Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchospirometry; Cetirizine; Cyclopropa

2002

Trials

8 trials available for fexofenadine and Asthma

ArticleYear
The effect of montelukast on wheal reactions in skin prick tests: a double-blind-placebo-controlled randomized trial.
    International journal of pediatric otorhinolaryngology, 2013, Volume: 77, Issue:10

    Topics: Acetates; Allergens; Animals; Asthma; Chi-Square Distribution; Child; Cyclopropanes; Dose-Response R

2013
Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.
    Allergology international : official journal of the Japanese Society of Allergology, 2009, Volume: 58, Issue:2

    Topics: Acetylcholine; Activities of Daily Living; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Antig

2009
Leukotriene receptor antagonist in the treatment of childhood allergic rhinitis--a randomized placebo-controlled study.
    Pediatric pulmonology, 2009, Volume: 44, Issue:11

    Topics: Acetates; Adolescent; Asthma; Child; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination;

2009
Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma.
    The Journal of allergy and clinical immunology, 2003, Volume: 111, Issue:2

    Topics: Acetates; Adenosine Monophosphate; Adult; Aged; Asthma; Bronchial Provocation Tests; Cetirizine; Cro

2003
Repeated dosing effects of mediator antagonists in inhaled corticosteroid-treated atopic asthmatic patients.
    Chest, 2004, Volume: 125, Issue:4

    Topics: Acetates; Adenosine Monophosphate; Administration, Inhalation; Adrenal Cortex Hormones; Anti-Allergi

2004
Addition of fexofenadine to inhaled corticosteroid therapy to reduce inflammatory biomarkers in atopic asthma.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005, Volume: 95, Issue:3

    Topics: Adenosine Monophosphate; Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adult; Alb

2005
Fexofenadine decreases sensitivity to and montelukast improves recovery from inhaled mannitol.
    American journal of respiratory and critical care medicine, 2001, Volume: 163, Issue:6

    Topics: Acetates; Administration, Inhalation; Adolescent; Adult; Aged; Anti-Asthmatic Agents; Asthma; Bronch

2001
Safety of fexofenadine in children treated for seasonal allergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2001, Volume: 87, Issue:1

    Topics: Asthma; Child; Double-Blind Method; Humans; Rhinitis, Allergic, Seasonal; Terfenadine; Therapeutic E

2001

Other Studies

4 other studies available for fexofenadine and Asthma

ArticleYear
Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale.
    Methods and findings in experimental and clinical pharmacology, 2008, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Butyrophenones; Cetirizine; Child; Chlorpheniram

2008
Allergies in India: a study on medication compliance.
    Journal of the Indian Medical Association, 2009, Volume: 107, Issue:7

    Topics: Adolescent; Adult; Anti-Allergic Agents; Asthma; Bronchodilator Agents; Budesonide; Child; Ethanolam

2009
[Effect of fexofenadine--selective antagonist of histamine receptor (H1) on histamine-induced bronchoconstriction].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2003, Volume: 14, Issue:79

    Topics: Adult; Anti-Allergic Agents; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response

2003
[Hay fever and asthma. Many of your patients have both].
    MMW Fortschritte der Medizin, 2002, Apr-25, Volume: 144, Issue:17

    Topics: Asthma; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outco

2002