fexinidazole has been researched along with Trypanosomiasis, African in 34 studies
*Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.94) | 18.7374 |
| 1990's | 2 (5.88) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 23 (67.65) | 24.3611 |
| 2020's | 8 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Fairlamb, AH; Oza, SL; Patterson, S; Read, KD; Sokolova, AY; Wyllie, S | 1 |
| Samant, BS; Sukhthankar, MG | 1 |
| Brun, R; Jędrysiak, R; Kaiser, M; Suwiński, J; Torreele, E; Trunz, BB; Tweats, D | 1 |
| Bacchi, CJ; Braillard, S; Chatelain, E; Denny, WA; Gaukel, E; Launay, D; Maes, L; Marshall, AJ; Mowbray, CE; Thompson, AM; Wring, SA; Yarlett, N | 1 |
| Bag, S; Caffrey, CR; Ceballos-Pérez, G; Cordon-Obras, C; Diaz-Gonzalez, R; Ferrins, L; Gamarro, F; García-Hernández, R; Gonzalez Pacanowska, D; Manzano, P; Martinez-Martinez, MS; Navarro, M; Pérez-Moreno, G; Pollastri, MP; Rojas-Barros, DI; Ruiz-Perez, LM; Tear, WF | 1 |
| Strub-Wourgaft, N; Tarral, A; Valverde Mordt, O | 1 |
| Bardonneau, C; Bernhard, S; Blesson, S; Delhomme, S; Fina Lubaki, JP; Ilunga Wa Kyhi, M; Kande Betu Kumesu, V; Kaninda Badibabi, L; Kasongo Bonama, A; Kavunga Lukula, P; Kuziena Mindele, W; Lumbala, C; Lumeya Vuvu, S; Mahenzi Mbembo, H; Mandula Mokenge, G; Mutombo Kalonji, W; Nganzobo Ngima, P; Ngolo Tete, D; Scherrer, B; Simon, F; Strub-Wourgaft, N; Tarral, A; Valverde Mordt, O | 1 |
| Balaña-Fouce, R; Domínguez-Asenjo, B; García-Estrada, C; Holanda, VN; Martínez-Valladares, M; Murugesan, S; Pérez-Pertejo, Y; Reguera, RM | 1 |
| Gudmundsson, KSS; Helleberg, BB; Helleberg, M; Kurtzhals, JAL | 1 |
| Bayão, TS; Cupertino, MDC; Gomes, AP; Siqueira-Batista, R | 1 |
| Fairlamb, AH | 1 |
| Akl, EA; Barrett, MP; Bergman, H; Chappuis, F; Erphas, O; Franco, JR; Kadima Ebeja, A; Kazumba, L; Lejon, V; Lindner, AK; Mwamba, E; Priotto, G; Seixas, J; Simarro, P; Villanueva, G | 1 |
| Kaiser, M; Mäser, P | 1 |
| Akwaso Masa, F; Bardonneau, C; Bernhard, S; Blesson, S; Botalema Bolengi, F; Delhomme, S; Kande Betu Ku Mesu, V; Kapongo Tshilumbwa, S; Lumbala, C; Lumeya Vuvu, S; Mahenzi Mbembo, H; Mayala Malu, T; Mpia Moke, C; Mpoyi Muamba Nzambi, D; Mudji E'kitiak, J; Mukendi Ilunga, M; Mutombo Kalonji, W; Ngolo Tete, D; Nkieri Matsho, M; Scherrer, B; Simon, F; Strub-Wourgaft, N; Tarral, A; Valverde Mordt, O | 1 |
| Alavijeh, MS; Burrell-Saward, H; Croft, SL; de LaFlor, R; Harris, AJ; Sallam, H; Ward, TH | 1 |
| Maxmen, A | 2 |
| Badibabi, LK; Bardonneau, C; Bernhard, S; Blesson, S; Bonama, AK; Dama, FR; Delhomme, S; Heradi, JA; Ilunga, M; Kalonji, WM; Kuziena, W; Lubaki, JF; Lukula, PK; Lumbala, C; Mandula, G; Mbembo, HM; Mesu, VKBK; Mordt, OV; Ngima, PN; Scherrer, B; Simon, F; Solomo, JLL; Strub-Wourgaft, N; Tarral, A; Tete, DN; Vuvu, SL | 1 |
| Pollastri, MP | 1 |
| Chappuis, F | 1 |
| Deeks, ED | 1 |
| Cavaleri, M; Harvey Allchurch, M; Nagercoil, N; Nambasa, V; Ntamabyaliro, N; Pelfrene, E; Ventura, FV | 1 |
| Blesson, S; Bray, MA; Evène, E; Felices, M; Gualano, V; Hovsepian, L; Mordt, OV; Sassella, D; Strub-Wourgaft, N; Tarral, A; Torreele, E | 1 |
| Ardiot, C; Blesson, S; Bompart, F; Bonnin, Y; Coleman, CH; Colonna, P; Dhai, A; Ecuru, J; Edielu, A; Hervé, C; Hirsch, F; Kouyaté, B; Mamzer-Bruneel, MF; Maoundé, D; Martinent, E; Ntsiba, H; Pelé, G; Quéva, G; Reinmund, MC; Sarr, SC; Sepou, A; Strub-Wourgaft, N; Tarral, A; Tetimian, D; Valverde, O; Van Nieuwenhove, S | 1 |
| Barrett, MP | 1 |
| Bourdin Trunz, B; Bray, MA; Brun, R; Kaiser, M; Mazué, G; Pécoul, B; Torreele, E; Tweats, D | 1 |
| Bot, C; Hall, BS; Kelly, JM; Wilkinson, SR | 1 |
| Barrett, MP; Brun, R; Don, R; Jacobs, RT; Wang, MZ | 1 |
| Bourdin Trunz, B; Bray, MA; Brun, R; Cal, M; Kaiser, M; Torreele, E | 1 |
| Bourdin Trunz, B; Torreele, E; Tweats, D | 1 |
| Barrett, MP; Croft, SL | 1 |
| Jennings, FW; Urquhart, GM | 1 |
| Atouguia, JM; Jennings, FW; Murray, M | 1 |
| Jennings, FW | 1 |
7 review(s) available for fexinidazole and Trypanosomiasis, African
| Article | Year |
|---|---|
Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates.
Topics: Animals; Chagas Disease; Humans; Leishmaniasis; Pharmaceutical Preparations; Trypanosomiasis, African | 2023 |
Fexinidazole for the treatment of human African trypanosomiasis.
Topics: Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African | 2019 |
Fexinidazole: First Global Approval.
Topics: Administration, Oral; Drug Approval; Humans; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2019 |
Potential new drugs for human African trypanosomiasis: some progress at last.
Topics: Animals; Benzamides; Boron Compounds; Drug Discovery; Drug Resistance; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.
Topics: Africa; Animals; Benzamides; Chagas Disease; Humans; Insect Vectors; Latin America; Nifurtimox; Nitro Compounds; Nitroimidazoles; Nitroreductases; Phosphoramide Mustards; Prodrugs; Protozoan Proteins; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 2011 |
Development of novel drugs for human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Benzoxazoles; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Haplorhini; Humans; Mice; Neglected Diseases; Nitroimidazoles; Trypanosoma brucei brucei; Trypanosomiasis, African | 2011 |
Management of trypanosomiasis and leishmaniasis.
Topics: Administration, Oral; Africa; Amphotericin B; Antiprotozoal Agents; Benzamides; Boron Compounds; Chagas Disease; Drug Therapy, Combination; Humans; India; Leishmaniasis; Nitroimidazoles; Pentamidine; Triazoles; Trypanosomiasis, African | 2012 |
3 trial(s) available for fexinidazole and Trypanosomiasis, African
| Article | Year |
|---|---|
Safety and efficacy of oral fexinidazole in children with gambiense human African trypanosomiasis: a multicentre, single-arm, open-label, phase 2-3 trial.
Topics: Administration, Oral; Child; Humans; Nitroimidazoles; Tablets; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2022 |
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial.
Topics: Administration, Oral; Adult; Democratic Republic of the Congo; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2018 |
Determination of an optimal dosing regimen for fexinidazole, a novel oral drug for the treatment of human African trypanosomiasis: first-in-human studies.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Cross-Over Studies; Dietary Fats; Dose-Response Relationship, Drug; Double-Blind Method; Food-Drug Interactions; Humans; Male; Middle Aged; Nitroimidazoles; Prodrugs; Suspensions; Tablets; Trypanocidal Agents; Trypanosomiasis, African; Young Adult | 2014 |
24 other study(ies) available for fexinidazole and Trypanosomiasis, African
| Article | Year |
|---|---|
Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.
Topics: Animals; Cell Line; Drug Resistance; Eflornithine; Humans; Mice; Nifurtimox; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Compounds containing 2-substituted imidazole ring for treatment against human African trypanosomiasis.
Topics: Animals; Humans; Imidazoles; Solubility; Stereoisomerism; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2011 |
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Leukocytes, Mononuclear; Mice; Molecular Structure; Mutagenicity Tests; Nitroimidazoles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Trypanosomiasis, African | 2011 |
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Molecular Structure; Nitroimidazoles; Small Molecule Libraries; Structure-Activity Relationship; Trypanosomiasis, African | 2018 |
Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-
Topics: Animals; Cell Survival; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Drug Repositioning; Glycogen Synthase Kinase 3 beta; Hepatocytes; High-Throughput Screening Assays; Humans; Leishmania donovani; Mice; Models, Molecular; Pyridazines; Rats; Structure-Activity Relationship; Substrate Specificity; Tissue Distribution; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2020 |
Development and Introduction of Fexinidazole into the Global Human African Trypanosomiasis Program.
Topics: Administration, Oral; Animals; Humans; Nitroimidazoles; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2022 |
Second stage human African Trypanosomiasis with Trypanosoma brucei rhodesiense treated with fexinidazole.
Topics: Animals; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2023 |
Fexinidazole and Human African Trypanosomiasis: good news for this important neglected tropical disease.
Topics: Humans; Neglected Diseases; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African | 2019 |
New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiprotozoal Agents; Child; Child, Preschool; Eflornithine; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Practice Guidelines as Topic; Trypanosoma brucei gambiense; Trypanosomiasis, African; World Health Organization; Young Adult | 2020 |
In Vitro Drug Efficacy Testing Against Trypanosoma brucei.
Topics: Calorimetry; Drug Evaluation, Preclinical; Humans; Life Cycle Stages; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 2020 |
Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study.
Topics: Administration, Oral; Adolescent; Adult; Aged; Democratic Republic of the Congo; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Severity of Illness Index; Treatment Outcome; Trypanosoma brucei gambiense; Trypanosomiasis, African; Young Adult | 2021 |
Dose-dependent effect and pharmacokinetics of fexinidazole and its metabolites in a mouse model of human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Cerebral Cortex; Cerebrospinal Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hippocampus; Luminescent Measurements; Mice; Nitroimidazoles; Plasma; Treatment Outcome; Trypanosoma; Trypanosomiasis, African; Whole Body Imaging | 2017 |
Sleeping sickness can now be cured with pills.
Topics: Administration, Oral; Clinical Trials, Phase III as Topic; Drug Approval; Drug Combinations; Humans; Nitroimidazoles; Trypanosomiasis, African | 2017 |
Fexinidazole: A New Drug for African Sleeping Sickness on the Horizon.
Topics: Clinical Trials as Topic; Drug Approval; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2018 |
Oral fexinidazole for human African trypanosomiasis.
Topics: Administration, Oral; Animals; Humans; Nitroimidazoles; Trypanosomiasis, African | 2018 |
The European Medicines Agency's scientific opinion on oral fexinidazole for human African trypanosomiasis.
Topics: Administration, Oral; Drug Approval; Drug-Related Side Effects and Adverse Reactions; Humans; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2019 |
Improving the Quality of Host Country Ethical Oversight of International Research: The Use of a Collaborative 'Pre-Review' Mechanism for a Study of Fexinidazole for Human African Trypanosomiasis.
Topics: Antiprotozoal Agents; Biomedical Research; Developing Countries; Ethical Review; Humans; International Cooperation; Nitroimidazoles; Trypanosomiasis, African | 2015 |
Busting the billion-dollar myth: how to slash the cost of drug development.
Topics: Africa; Amodiaquine; Anti-Bacterial Agents; Artemisinins; Benzamides; Boron Compounds; Child; Clinical Trials as Topic; Cooperative Behavior; Developed Countries; Developing Countries; Drug Approval; Drug Combinations; Drug Costs; Drug Discovery; Drug Industry; Drug Repositioning; Drug Resistance, Microbial; Female; Humans; Malaria; Neglected Diseases; Negotiating; Nitroimidazoles; Organizations, Nonprofit; Sample Size; Trypanosomiasis, African; World Health Organization | 2016 |
Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Disease Models, Animal; Dogs; Female; Inhibitory Concentration 50; Mice; Nitroimidazoles; Parasitic Sensitivity Tests; Rats; Treatment Outcome; Trypanosomiasis, African | 2010 |
Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness.
Topics: Animals; Female; Humans; Mice; Nitroimidazoles; Parasitic Sensitivity Tests; Safrole; Sulfones; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2011 |
Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness).
Topics: Animals; Bacteria; Bone Marrow Cells; Hepatocytes; Humans; Leukocytes, Mononuclear; Male; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Nitroimidazoles; Nitroreductases; Rats; Trypanocidal Agents; Trypanosomiasis, African | 2012 |
The use of the 2 substituted 5-nitroimidazole, Fexinidazole (Hoe 239) in the treatment of chronic T. brucei infections in mice.
Topics: Animals; Antiprotozoal Agents; Chronic Disease; Diminazene; Drug Therapy, Combination; Female; Mice; Mice, Inbred Strains; Nitroimidazoles; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1983 |
Topical chemotherapy for experimental murine African CNS-trypanosomiasis: the successful use of the arsenical, melarsoprol, combined with the 5-nitroimidazoles, fexinidazole or MK-436.
Topics: Administration, Topical; Animals; Antiprotozoal Agents; Dose-Response Relationship, Drug; Drug Combinations; Female; Gels; Melarsoprol; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African | 1996 |
Chemotherapy of CNS-trypanosomiasis: the combined use of the arsenicals and nitro-compounds.
Topics: Animals; Antiprotozoal Agents; Arsenicals; Brain Diseases; Drug Synergism; Drug Therapy, Combination; Female; Ketoconazole; Metronidazole; Mice; Nifurtimox; Nitro Compounds; Nitroimidazoles; Oxidation-Reduction; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1991 |