fexinidazole has been researched along with Chagas Disease in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 5 (41.67) | 2.80 |
| Authors | Studies |
|---|---|
| Avery, VM; Charman, SA; Chatelain, E; Cornwall, S; Denny, WA; Francisco, AF; Keenan, M; Kelly, JM; Marshall, AJ; O'Connor, PD; Perez, CJ; Read, KD; Riley, J; Sykes, ML; Thompson, AM; Thompson, RCA; White, KL; Zulfiqar, B | 1 |
| Barreira, F; Bilbe, G; Blum, B; Gascón, J; Ortiz, L; Palacios, A; Pinazo, MJ; Pinto, J; Ribeiro, I; Rojas, G; Schijman, AG; Strub-Wourgaft, N; Torrico, F; Vaillant, M | 1 |
| de Souza, W; Zuma, AA | 1 |
| Balaña-Fouce, R; Domínguez-Asenjo, B; García-Estrada, C; Holanda, VN; Martínez-Valladares, M; Murugesan, S; Pérez-Pertejo, Y; Reguera, RM | 1 |
| Bahia, MT; Diniz, LF; Gonçalves, KR; Mazzeti, AL; Mota, SLA; Pereira, DE | 1 |
| Burki, T | 1 |
| Bahia, MT; Caldas, IS; Charman, SA; Chatelain, E; Diniz, Lde F; Gonçalves, KR; Koltun, M; Marques, LF; Mazzeti, AL; Mota, LW; Nascimento, AF; Saunders, J; Scandale, I; Shackleford, DM; Talvani, A; White, KL | 1 |
| Charman, SA; Chatelain, E; Chen, G; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Osuna-Cabello, M; Read, KD; Saunders, J; Shackleford, DM; White, KL | 1 |
| Bot, C; Hall, BS; Kelly, JM; Wilkinson, SR | 1 |
| Bahia, MT; Caldas, IS; de Andrade, IM; Diniz, Lde F; do Nascimento, ÁF; Martins, TA; Ribeiro, I; Talvani, A; Torreele, E; Trunz, BB | 1 |
| Barrett, MP; Croft, SL | 1 |
| Raether, W; Seidenath, H | 1 |
3 review(s) available for fexinidazole and Chagas Disease
| Article | Year |
|---|---|
Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates.
Topics: Animals; Chagas Disease; Humans; Leishmaniasis; Pharmaceutical Preparations; Trypanosomiasis, African | 2023 |
Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.
Topics: Africa; Animals; Benzamides; Chagas Disease; Humans; Insect Vectors; Latin America; Nifurtimox; Nitro Compounds; Nitroimidazoles; Nitroreductases; Phosphoramide Mustards; Prodrugs; Protozoan Proteins; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 2011 |
Management of trypanosomiasis and leishmaniasis.
Topics: Administration, Oral; Africa; Amphotericin B; Antiprotozoal Agents; Benzamides; Boron Compounds; Chagas Disease; Drug Therapy, Combination; Humans; India; Leishmaniasis; Nitroimidazoles; Pentamidine; Triazoles; Trypanosomiasis, African | 2012 |
1 trial(s) available for fexinidazole and Chagas Disease
| Article | Year |
|---|---|
A Phase 2, Randomized, Multicenter, Placebo-Controlled, Proof-of-Concept Trial of Oral Fexinidazole in Adults With Chronic Indeterminate Chagas Disease.
Topics: Adult; Chagas Disease; Double-Blind Method; Humans; Neutropenia; Nitroimidazoles; Treatment Outcome | 2023 |
8 other study(ies) available for fexinidazole and Chagas Disease
| Article | Year |
|---|---|
Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy.
Topics: Animals; Chagas Disease; Drug Evaluation, Preclinical; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Fexinidazole interferes with the growth and structural organization of Trypanosoma cruzi.
Topics: Chagas Disease; Humans; Morphogenesis; Nitroimidazoles; Trypanosoma cruzi | 2022 |
Combination therapy using nitro compounds improves the efficacy of experimental Chagas disease treatment.
Topics: Animals; Chagas Disease; Drug Therapy, Combination; Female; Humans; Inhibitory Concentration 50; Mice; Neglected Diseases; Nifurtimox; Nitro Compounds; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Sulfones | 2021 |
Recognition for Chagas disease.
Topics: Chagas Disease; Humans; Latin America; Neglected Diseases; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease.
Topics: Administration, Oral; Animals; Biotransformation; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Mice; Nitroimidazoles; Sulfones; Sulfoxides; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
Topics: Animals; Area Under Curve; Chagas Disease; Disease Models, Animal; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Fexinidazole: a potential new drug candidate for Chagas disease.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Female; Mice; Nitroimidazoles; Parasitemia; Survival Analysis; Treatment Outcome; Trypanosoma cruzi | 2012 |
The activity of fexinidazole (HOE 239) against experimental infections with Trypanosoma cruzi, trichomonads and Entamoeba histolytica.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Cricetinae; Dogs; Entamoebiasis; Female; Guinea Pigs; Macaca; Male; Mesocricetus; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Nitroimidazoles; Protozoan Infections; Rabbits; Rats; Trichomonas Infections; Tritrichomonas | 1983 |