fexinidazole has been researched along with African Sleeping Sickness in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.94) | 18.7374 |
| 1990's | 2 (5.88) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 23 (67.65) | 24.3611 |
| 2020's | 8 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Fairlamb, AH; Oza, SL; Patterson, S; Read, KD; Sokolova, AY; Wyllie, S | 1 |
| Samant, BS; Sukhthankar, MG | 1 |
| Brun, R; Jędrysiak, R; Kaiser, M; Suwiński, J; Torreele, E; Trunz, BB; Tweats, D | 1 |
| Bacchi, CJ; Braillard, S; Chatelain, E; Denny, WA; Gaukel, E; Launay, D; Maes, L; Marshall, AJ; Mowbray, CE; Thompson, AM; Wring, SA; Yarlett, N | 1 |
| Bag, S; Caffrey, CR; Ceballos-Pérez, G; Cordon-Obras, C; Diaz-Gonzalez, R; Ferrins, L; Gamarro, F; García-Hernández, R; Gonzalez Pacanowska, D; Manzano, P; Martinez-Martinez, MS; Navarro, M; Pérez-Moreno, G; Pollastri, MP; Rojas-Barros, DI; Ruiz-Perez, LM; Tear, WF | 1 |
| Strub-Wourgaft, N; Tarral, A; Valverde Mordt, O | 1 |
| Bardonneau, C; Bernhard, S; Blesson, S; Delhomme, S; Fina Lubaki, JP; Ilunga Wa Kyhi, M; Kande Betu Kumesu, V; Kaninda Badibabi, L; Kasongo Bonama, A; Kavunga Lukula, P; Kuziena Mindele, W; Lumbala, C; Lumeya Vuvu, S; Mahenzi Mbembo, H; Mandula Mokenge, G; Mutombo Kalonji, W; Nganzobo Ngima, P; Ngolo Tete, D; Scherrer, B; Simon, F; Strub-Wourgaft, N; Tarral, A; Valverde Mordt, O | 1 |
| Balaña-Fouce, R; Domínguez-Asenjo, B; García-Estrada, C; Holanda, VN; Martínez-Valladares, M; Murugesan, S; Pérez-Pertejo, Y; Reguera, RM | 1 |
| Gudmundsson, KSS; Helleberg, BB; Helleberg, M; Kurtzhals, JAL | 1 |
| Bayão, TS; Cupertino, MDC; Gomes, AP; Siqueira-Batista, R | 1 |
| Fairlamb, AH | 1 |
| Akl, EA; Barrett, MP; Bergman, H; Chappuis, F; Erphas, O; Franco, JR; Kadima Ebeja, A; Kazumba, L; Lejon, V; Lindner, AK; Mwamba, E; Priotto, G; Seixas, J; Simarro, P; Villanueva, G | 1 |
| Kaiser, M; Mäser, P | 1 |
| Akwaso Masa, F; Bardonneau, C; Bernhard, S; Blesson, S; Botalema Bolengi, F; Delhomme, S; Kande Betu Ku Mesu, V; Kapongo Tshilumbwa, S; Lumbala, C; Lumeya Vuvu, S; Mahenzi Mbembo, H; Mayala Malu, T; Mpia Moke, C; Mpoyi Muamba Nzambi, D; Mudji E'kitiak, J; Mukendi Ilunga, M; Mutombo Kalonji, W; Ngolo Tete, D; Nkieri Matsho, M; Scherrer, B; Simon, F; Strub-Wourgaft, N; Tarral, A; Valverde Mordt, O | 1 |
| Alavijeh, MS; Burrell-Saward, H; Croft, SL; de LaFlor, R; Harris, AJ; Sallam, H; Ward, TH | 1 |
| Maxmen, A | 2 |
| Badibabi, LK; Bardonneau, C; Bernhard, S; Blesson, S; Bonama, AK; Dama, FR; Delhomme, S; Heradi, JA; Ilunga, M; Kalonji, WM; Kuziena, W; Lubaki, JF; Lukula, PK; Lumbala, C; Mandula, G; Mbembo, HM; Mesu, VKBK; Mordt, OV; Ngima, PN; Scherrer, B; Simon, F; Solomo, JLL; Strub-Wourgaft, N; Tarral, A; Tete, DN; Vuvu, SL | 1 |
| Pollastri, MP | 1 |
| Chappuis, F | 1 |
| Deeks, ED | 1 |
| Cavaleri, M; Harvey Allchurch, M; Nagercoil, N; Nambasa, V; Ntamabyaliro, N; Pelfrene, E; Ventura, FV | 1 |
| Blesson, S; Bray, MA; Evène, E; Felices, M; Gualano, V; Hovsepian, L; Mordt, OV; Sassella, D; Strub-Wourgaft, N; Tarral, A; Torreele, E | 1 |
| Ardiot, C; Blesson, S; Bompart, F; Bonnin, Y; Coleman, CH; Colonna, P; Dhai, A; Ecuru, J; Edielu, A; Hervé, C; Hirsch, F; Kouyaté, B; Mamzer-Bruneel, MF; Maoundé, D; Martinent, E; Ntsiba, H; Pelé, G; Quéva, G; Reinmund, MC; Sarr, SC; Sepou, A; Strub-Wourgaft, N; Tarral, A; Tetimian, D; Valverde, O; Van Nieuwenhove, S | 1 |
| Barrett, MP | 1 |
| Bourdin Trunz, B; Bray, MA; Brun, R; Kaiser, M; Mazué, G; Pécoul, B; Torreele, E; Tweats, D | 1 |
| Bot, C; Hall, BS; Kelly, JM; Wilkinson, SR | 1 |
| Barrett, MP; Brun, R; Don, R; Jacobs, RT; Wang, MZ | 1 |
| Bourdin Trunz, B; Bray, MA; Brun, R; Cal, M; Kaiser, M; Torreele, E | 1 |
| Bourdin Trunz, B; Torreele, E; Tweats, D | 1 |
| Barrett, MP; Croft, SL | 1 |
| Jennings, FW; Urquhart, GM | 1 |
| Atouguia, JM; Jennings, FW; Murray, M | 1 |
| Jennings, FW | 1 |
7 review(s) available for fexinidazole and African Sleeping Sickness
| Article | Year |
|---|---|
Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates.
Topics: Animals; Chagas Disease; Humans; Leishmaniasis; Pharmaceutical Preparations; Trypanosomiasis, African | 2023 |
Fexinidazole for the treatment of human African trypanosomiasis.
Topics: Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African | 2019 |
Fexinidazole: First Global Approval.
Topics: Administration, Oral; Drug Approval; Humans; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2019 |
Potential new drugs for human African trypanosomiasis: some progress at last.
Topics: Animals; Benzamides; Boron Compounds; Drug Discovery; Drug Resistance; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.
Topics: Africa; Animals; Benzamides; Chagas Disease; Humans; Insect Vectors; Latin America; Nifurtimox; Nitro Compounds; Nitroimidazoles; Nitroreductases; Phosphoramide Mustards; Prodrugs; Protozoan Proteins; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 2011 |
Development of novel drugs for human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Benzoxazoles; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Haplorhini; Humans; Mice; Neglected Diseases; Nitroimidazoles; Trypanosoma brucei brucei; Trypanosomiasis, African | 2011 |
Management of trypanosomiasis and leishmaniasis.
Topics: Administration, Oral; Africa; Amphotericin B; Antiprotozoal Agents; Benzamides; Boron Compounds; Chagas Disease; Drug Therapy, Combination; Humans; India; Leishmaniasis; Nitroimidazoles; Pentamidine; Triazoles; Trypanosomiasis, African | 2012 |
3 trial(s) available for fexinidazole and African Sleeping Sickness
| Article | Year |
|---|---|
Safety and efficacy of oral fexinidazole in children with gambiense human African trypanosomiasis: a multicentre, single-arm, open-label, phase 2-3 trial.
Topics: Administration, Oral; Child; Humans; Nitroimidazoles; Tablets; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2022 |
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial.
Topics: Administration, Oral; Adult; Democratic Republic of the Congo; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2018 |
Determination of an optimal dosing regimen for fexinidazole, a novel oral drug for the treatment of human African trypanosomiasis: first-in-human studies.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Cross-Over Studies; Dietary Fats; Dose-Response Relationship, Drug; Double-Blind Method; Food-Drug Interactions; Humans; Male; Middle Aged; Nitroimidazoles; Prodrugs; Suspensions; Tablets; Trypanocidal Agents; Trypanosomiasis, African; Young Adult | 2014 |
24 other study(ies) available for fexinidazole and African Sleeping Sickness
| Article | Year |
|---|---|
Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.
Topics: Animals; Cell Line; Drug Resistance; Eflornithine; Humans; Mice; Nifurtimox; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Compounds containing 2-substituted imidazole ring for treatment against human African trypanosomiasis.
Topics: Animals; Humans; Imidazoles; Solubility; Stereoisomerism; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2011 |
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Leukocytes, Mononuclear; Mice; Molecular Structure; Mutagenicity Tests; Nitroimidazoles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Trypanosomiasis, African | 2011 |
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Molecular Structure; Nitroimidazoles; Small Molecule Libraries; Structure-Activity Relationship; Trypanosomiasis, African | 2018 |
Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-
Topics: Animals; Cell Survival; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Drug Repositioning; Glycogen Synthase Kinase 3 beta; Hepatocytes; High-Throughput Screening Assays; Humans; Leishmania donovani; Mice; Models, Molecular; Pyridazines; Rats; Structure-Activity Relationship; Substrate Specificity; Tissue Distribution; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2020 |
Development and Introduction of Fexinidazole into the Global Human African Trypanosomiasis Program.
Topics: Administration, Oral; Animals; Humans; Nitroimidazoles; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2022 |
Second stage human African Trypanosomiasis with Trypanosoma brucei rhodesiense treated with fexinidazole.
Topics: Animals; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2023 |
Fexinidazole and Human African Trypanosomiasis: good news for this important neglected tropical disease.
Topics: Humans; Neglected Diseases; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African | 2019 |
New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiprotozoal Agents; Child; Child, Preschool; Eflornithine; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Practice Guidelines as Topic; Trypanosoma brucei gambiense; Trypanosomiasis, African; World Health Organization; Young Adult | 2020 |
In Vitro Drug Efficacy Testing Against Trypanosoma brucei.
Topics: Calorimetry; Drug Evaluation, Preclinical; Humans; Life Cycle Stages; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 2020 |
Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study.
Topics: Administration, Oral; Adolescent; Adult; Aged; Democratic Republic of the Congo; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Severity of Illness Index; Treatment Outcome; Trypanosoma brucei gambiense; Trypanosomiasis, African; Young Adult | 2021 |
Dose-dependent effect and pharmacokinetics of fexinidazole and its metabolites in a mouse model of human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Cerebral Cortex; Cerebrospinal Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hippocampus; Luminescent Measurements; Mice; Nitroimidazoles; Plasma; Treatment Outcome; Trypanosoma; Trypanosomiasis, African; Whole Body Imaging | 2017 |
Sleeping sickness can now be cured with pills.
Topics: Administration, Oral; Clinical Trials, Phase III as Topic; Drug Approval; Drug Combinations; Humans; Nitroimidazoles; Trypanosomiasis, African | 2017 |
Fexinidazole: A New Drug for African Sleeping Sickness on the Horizon.
Topics: Clinical Trials as Topic; Drug Approval; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2018 |
Oral fexinidazole for human African trypanosomiasis.
Topics: Administration, Oral; Animals; Humans; Nitroimidazoles; Trypanosomiasis, African | 2018 |
The European Medicines Agency's scientific opinion on oral fexinidazole for human African trypanosomiasis.
Topics: Administration, Oral; Drug Approval; Drug-Related Side Effects and Adverse Reactions; Humans; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African | 2019 |
Improving the Quality of Host Country Ethical Oversight of International Research: The Use of a Collaborative 'Pre-Review' Mechanism for a Study of Fexinidazole for Human African Trypanosomiasis.
Topics: Antiprotozoal Agents; Biomedical Research; Developing Countries; Ethical Review; Humans; International Cooperation; Nitroimidazoles; Trypanosomiasis, African | 2015 |
Busting the billion-dollar myth: how to slash the cost of drug development.
Topics: Africa; Amodiaquine; Anti-Bacterial Agents; Artemisinins; Benzamides; Boron Compounds; Child; Clinical Trials as Topic; Cooperative Behavior; Developed Countries; Developing Countries; Drug Approval; Drug Combinations; Drug Costs; Drug Discovery; Drug Industry; Drug Repositioning; Drug Resistance, Microbial; Female; Humans; Malaria; Neglected Diseases; Negotiating; Nitroimidazoles; Organizations, Nonprofit; Sample Size; Trypanosomiasis, African; World Health Organization | 2016 |
Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Disease Models, Animal; Dogs; Female; Inhibitory Concentration 50; Mice; Nitroimidazoles; Parasitic Sensitivity Tests; Rats; Treatment Outcome; Trypanosomiasis, African | 2010 |
Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness.
Topics: Animals; Female; Humans; Mice; Nitroimidazoles; Parasitic Sensitivity Tests; Safrole; Sulfones; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2011 |
Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness).
Topics: Animals; Bacteria; Bone Marrow Cells; Hepatocytes; Humans; Leukocytes, Mononuclear; Male; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Nitroimidazoles; Nitroreductases; Rats; Trypanocidal Agents; Trypanosomiasis, African | 2012 |
The use of the 2 substituted 5-nitroimidazole, Fexinidazole (Hoe 239) in the treatment of chronic T. brucei infections in mice.
Topics: Animals; Antiprotozoal Agents; Chronic Disease; Diminazene; Drug Therapy, Combination; Female; Mice; Mice, Inbred Strains; Nitroimidazoles; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1983 |
Topical chemotherapy for experimental murine African CNS-trypanosomiasis: the successful use of the arsenical, melarsoprol, combined with the 5-nitroimidazoles, fexinidazole or MK-436.
Topics: Administration, Topical; Animals; Antiprotozoal Agents; Dose-Response Relationship, Drug; Drug Combinations; Female; Gels; Melarsoprol; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African | 1996 |
Chemotherapy of CNS-trypanosomiasis: the combined use of the arsenicals and nitro-compounds.
Topics: Animals; Antiprotozoal Agents; Arsenicals; Brain Diseases; Drug Synergism; Drug Therapy, Combination; Female; Ketoconazole; Metronidazole; Mice; Nifurtimox; Nitro Compounds; Nitroimidazoles; Oxidation-Reduction; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1991 |