feruloyltyramine and Alzheimer-Disease

In Alzheimer's disease (AD) the accumulation of amyloid β (Aβ) plaques in the brain leads to neuroinflammation, neuronal cell dysfunction, and progressive memory loss. Therefore, blocking the formation of Aβ plaques has emerged as one of the most promising strategies to develop AD treatments. Hempseed is widely used as a food, and recently its compounds have shown beneficial effects on neuroinflammation. The objective of this study was to investigate whether a fraction rich in phenyl amide compounds,

Topics: Alzheimer Disease; Amides; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cannabis; Cell Line; Gene Expression; Mice; Molecular Structure; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phytochemicals; PPAR gamma; Seeds; Spain; Tyramine