ferulic-acid has been researched along with Chemical-and-Drug-Induced-Liver-Injury* in 1 studies
1 other study(ies) available for ferulic-acid and Chemical-and-Drug-Induced-Liver-Injury
| Article | Year |
|---|---|
Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy.
Herein we report an efficient two step synthesis and biological assessment of 12 racemic tetrahydropyranodiquinolin-8-amines derivatives as antioxidant, cholinesterase inhibitors and non-hepatotoxic agents. Based on the results of the primary screening, we identified 7-(3-methoxyphenyl)-9,10,11,12-tetrahydro-7H-pyrano[2,3-b:5,6-h']diquinolin-8-amine (2h) as a particularly interesting non-hepatotoxic compound that shows moderate antioxidant activity (1.83 equiv Trolox in the ORAC assay), a non competitive inhibition of hAChE (IC Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Antioxidants; Blood-Brain Barrier; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; GPI-Linked Proteins; Humans | 2017 |