ferrous-fumarate has been researched along with Placental-Insufficiency* in 2 studies
1 trial(s) available for ferrous-fumarate and Placental-Insufficiency
| Article | Year |
|---|---|
The effect of combined iron therapy (Chemiron) and single iron therapy on the dexamethasone-estriol reaction test for placenta insufficiency during normal pregnancy.
Impaired uteroplacental perfusion has been shown to play a role in the pathogenesis of some complicated pregnancies with placenta insufficiency. Apart from this, lower oestrogen, magnesium and zinc are found in many of these conditions in the third trimester with placenta insufficiency. In this study, we examined the effect of a 4 mg intravenous dexamethasone injection on estriol, since maternal cortisol or synthetic corticosteroids cross the placental barrier and inhibit the release of dehydroepiandrostesone sulfate in the fetal adrenals. Dexamathasone was found to suppress estriol levels in all groups but a significant difference in suppression was found between the Chemiron--a new combination hematinic--and the control single iron therapy groups. Our preliminary results showed that Chemiron has a protective effect on the development of placenta insufficiency during the third trimester of pregnancy. Topics: Adult; Anemia; Ascorbic Acid; Dexamethasone; Drug Combinations; Estriol; Female; Ferrous Compounds; Folic Acid; Hematinics; Humans; Magnesium Sulfate; Placental Insufficiency; Pregnancy; Pregnancy Tests; Pregnancy Trimester, Third; Vitamin B 12; Zinc Sulfate | 1999 |
1 other study(ies) available for ferrous-fumarate and Placental-Insufficiency
| Article | Year |
|---|---|
Effect of combined iron therapy (Chemiron) and single iron therapy on the dexamethasone-estriol test effect, on plasma dehydroepiandrosterone sulfate during normal pregnancy.
It is established that during human pregnancy maternal and fetal serum dehydroepiandrosterone sulfate (DHAS), which has been shown to arise mainly by adrenal secretion, serves as a substrate in the biosynthesis of placental oestrogen. The conversion to oestrogen is reflected by decreased DHAS and increased oestrogen concentration in the peripheral maternal blood. Impaired uteroplacental perfusion has been shown to play a role in the pathogenesis of some complicated pregnancies with placenta insufficiency. Apart from this, lower oestrogen, magnesium and zinc levels are found in many of these conditions in the third trimester with placenta insufficiency. In this study, we examined the effect of 4 mg Dexamethasone intravenously on dehydroepiandrosterone sulfate, since materal cortisol or synthetic corticosteroids cross the placental barrier and inhibit the release of dehydroepiandrosterone sulfate in fetal adrenals. Dexamethasone was found to suppress dehydroepiandrosterone sulfate levels in all groups but a significant difference in suppression was found between the Chemiron--a hematinic combination--and the single iron therapy control groups. Our preliminary results showed that Chemiron has a protective effect on the development of placenta insufficiency during the third trimester of pregnancy. Topics: Adult; Anti-Inflammatory Agents; Circadian Rhythm; Dehydroepiandrosterone Sulfate; Dexamethasone; Estriol; Female; Ferrous Compounds; Humans; Placental Insufficiency; Pregnancy | 1998 |